Goat's Rue - Aspirin, Carisoprodol, Codeine Phosphate Interaction
Herbal: Goat's Rue
Also Known As: Galega officinalis
Drug: Aspirin, Carisoprodol, Codeine Phosphate
Brand names:
Soma Compound w/ Codeine
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Aspirin, Carisoprodol, Codeine Phosphate is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Laboratory research suggests that goat's rue extract can inhibit platelet aggregation. Theoretically, goat's rue might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Atanasov AT. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Med Plants 1995;3:71-6.
- Atanasov, A. T. and Spasov, V. Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation. Folia Med.(Plovdiv.) 1999;41(1):46-50.
- Atanasov, A. T. and Spasov, V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. J.Ethnopharmacol. 2000;69(3):235-240.
- Atanasov, A. T. and Tchorbanov, B. Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation. J.Med.Food 2002;5(4):229-234.
- Atanasov, A. T. and Tchorbanov, B. J. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71.
Goat's Rue Overview
Goat's rue (Galega officinalis) is a plant often used as a dietary supplement. It has historically been recognized for its potential as a galactagogue, aiding in increasing milk production in nursing mothers. Additionally, it has garnered attention in the realm of diabetes management due to compounds like guanidine and galegine that may help regulate blood sugar levels and improve insulin sensitivity. As a dietary supplement, it's important to exercise caution and consult a healthcare professional, especially if you have underlying medical conditions or are taking medications.
Goat's Rue - More Interactions
Goat's Rue interacts with 121 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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