Greater Burnet + Cladribine
Cladribine brand names: Leustatin, Mavenclad.
We found no known interaction between Greater Burnet and Cladribine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Greater Burnet and Cladribine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Cladribine and Greater Burnet in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Greater Burnet at all — not against Cladribine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Greater Burnet safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Cladribine
This page covers Greater Burnet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cladribine page lists 70 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate) and Andrographis (moderate).
By severity: 1 major · 59 moderate · 10 minor.
From our pharmacist’s overview on the Cladribine page
“Cladribine (Leustatin, Mavenclad) treats hairy cell leukemia and relapsing multiple sclerosis by deliberately knocking down part of the immune system, so this list calls for real vigilance. Of the 70 supplements and herbs on file, 53 are immune stimulators, herbs like astragalus, ashwagandha, and ginseng that could push immunity back u…”
Reviewed by 2 · Jul 18, 2026
Where Greater Burnet and Cladribine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,290 of 1,452 supplements looked up here in the last 7 days
#2,575 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Greater Burnet is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Greater Burnet reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Greater Burnet and Cladribine records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Greater Burnet
What is Greater Burnet?
- Diarrhea and digestive upset
- Minor bleeding and wounds
- Burns and skin irritation (topical)
- Sore throat and mouth inflammation
- Hemorrhoids
Greater Burnet (Sanguisorba officinalis) is a traditional herb whose tannin-rich root has long been used for diarrhea, minor bleeding, and skin problems. Modern human evidence for these uses is very limited, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.
Sanguisorba officinalis · Rosaceae · Root and rhizome (sometimes the leaves and aerial parts) · Dried root, tea/decoction, tincture, powder, topical preparations
An interaction check asks whether these two react with each other — it does not ask whether Greater Burnet is a good idea for someone in your situation. Here is what our Greater Burnet record says about it on its own.
Greater Burnet: dosing
There is no well-established standardized dose for Greater Burnet. Traditional use varies widely depending on the form (tea, tincture, powder, or topical) and the part of the plant.Because reliable dosing studies are lacking, the safest approach is to follow the directions on the product label and not exceed the recommended amount. They can help you decide whether it is appropriate and what amount, if any, is reasonable.
From our Greater Burnet monograph — the full record covers uses, side effects and every documented interaction.
About Cladribine
What Is Cladribine Used For?
Brand names: Leustatin, Mavenclad
Cladribine tablets (brand name Mavenclad) are used to treat relapsing forms of multiple sclerosis (MS) in adults — specifically relapsing-remitting MS and active secondary progressive MS. Because of its significant safety profile, it is generally reserved for patients who haven't responded well to, or can't tolerate, other MS medicines. It is not recommended for clinically isolated syndrome (CIS), a first episode that may or may not lead to MS.
Cladribine injection (given intravenously) is a separate product used to treat active hairy cell leukemia — a rare blood cancer — in patients who have clinically significant anemia, low white blood cell counts, low platelets, or disease-related symptoms.
Most-Reported Side Effects for Cladribine
From FAERS, the FDA’s public side-effect reporting system (9,555 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Greater Burnet
Browse every other medication we’ve checked against Greater Burnet — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Greater Burnet against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Greater Burnet list.
Greater Burnet References
The 2 sources that drive our Greater Burnet monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Greater Burnet is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Herbs and Supplements — MedlinePlus Source
- About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Greater Burnet and Cladribine Together: Common Questions
Is it safe to take Greater Burnet with Cladribine?
Does Cladribine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Cladribine and Greater Burnet?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.