Drug & supplement interaction

Greater Celandine + Finerenone

Finerenone brand name: Kerendia.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Greater Celandine and Finerenone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Greater Celandine and Finerenone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Finerenone and Greater Celandine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Greater Celandine safety at a glance

Greater Celandine overall Avoid Oral use has been linked to serious, sometimes severe liver damage.

Pregnancy Avoid Not enough safety data and known toxicity make it unsafe during pregnancy.

Breastfeeding Avoid No reliable safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Finerenone and Greater Celandine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Finerenone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Finerenone is filed under 3 classifications — potassium-sparing diuretics, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Greater Celandine has documented interactions with 4 drug classes — the most serious being cytochrome p450 2d6 (cyp2d6) substrates (moderate), hepatotoxic drugs (moderate) and immunosuppressants (moderate) — and none of Finerenone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Greater Celandine Does Interact With Other Medications

Greater Celandine has 625 moderate known drug interactions in our database — Finerenone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 625 No known interaction 2,205 (incl. Finerenone)

Taking anything else?

Check Another of Your Medications Against Greater Celandine

Covers the 2,830 medications we’ve checked against Greater Celandine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Greater Celandine and Finerenone May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

Kidney problems Worth acting on reported in 22.8% of FDA reports for Finerenone Additional detail
Greater Celandine
“Orally, greater celandine extract has caused a single case of hemolytic anemia. This resulted in thrombocytopenia, destruction of liver cells, and kidney failure, requiring treatment.

Intravenously, a derivative of the greater celandine constituent chelidonine (Ukrain) can cause bleeding.”

Greater Celandine · Natural Medicines adverse-effect record, reported in anemia.
3 sources cited

53508. Pinto, Garcia, V, Vicente, P. R., Barez, A., Soto, I., Candas, M. A., and Coma, A. [Hemolytic anemia induced by Chelidonium majus. Clinical case]. Sangre (Barc.) 1990;35(5):401-403.

13409. Ernst E, Schmidt K. Ukrain - a new cancer cure? A systematic review of randomised clinical trials. BMC Cancer 2005;5:69. PubMed

53460. Gansauge, F., Ramadani, M., Pressmar, J., Gansauge, S., Muehling, B., Stecker, K., Cammerer, G., Leder, G., and Beger, H. G. NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial. Langenbecks Arch.Surg. 2002;38 PubMed
Finerenone

Listed in the ADVERSE REACTIONS section of the FDA label for Finerenone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Greater Celandine but not commonly for Finerenone: a low platelet count, liver problems, a skin rash and diarrhea.

Effects for Finerenone come from the ADVERSE REACTIONS section of its FDA label; effects for Greater Celandine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 2,960 voluntary FDA FAERS reports for Finerenone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Greater Celandine or Finerenone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Greater Celandine or Finerenone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Drug Classification Question Answered by Dr. Brian Staiger, PharmD · March 2024 ›

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Finerenone

This page covers Greater Celandine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Finerenone page lists 146 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 101 moderate · 42 minor.

From our pharmacist’s overview on the Finerenone page

“Kerendia (finerenone) protects the kidneys and heart in people with type 2 diabetes and chronic kidney disease, and because the body clears it through one main enzyme, CYP3A4, its supplement list calls for genuine care. Of the 146 ingredients on file, 121 can push that enzyme up or down, letting finerenone drift too high or too low.”

Reviewed by 2 · Jul 18, 2026

Open the Finerenone interaction page

One more smart check

Taking Greater Celandine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 11 real supplement products containing Greater Celandine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Greater Celandine. Even though Greater Celandine itself has no known interaction with Finerenone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Greater Celandine and Finerenone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Greater Celandine

Top half

#661 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Finerenone

Steady interest

#2,279 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Greater Celandine reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Greater Celandine and Finerenone records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Greater Celandine

What is Greater Celandine?

Digestive and gallbladder complaints
Stomach cramps and bloating
Topical use for warts and skin growths
Liver and gallbladder 'cleansing'
Mild pain relief

Greater celandine is a traditional herb most often promoted for digestive and gallbladder complaints, but solid human evidence for any use is lacking. More importantly, it has been linked to serious and sometimes severe liver injury, so most experts advise against taking it by mouth. If you are considering it, talk with your pharmacist or doctor first.

Chelidonium majus · Papaveraceae · Aerial parts (leaves, stems, flowers), root, and the yellow-orange latex (sap) · Capsules, tinctures, dried herb for tea, liquid extracts, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Greater Celandine is a good idea for someone in your situation. Here is what our Greater Celandine record says about it on its own.

Greater Celandine: dosing

There is no well-established, standardized safe dose for greater celandine. Products vary widely in how they are made and how much alkaloid they contain, which makes consistent dosing difficult.Given the documented risk of liver injury, we do not recommend a specific dose. If you choose to use a product despite these concerns, follow the directions on the label and do not exceed them.

From our Greater Celandine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Greater Celandine monograph & all interactions

Medication

About Finerenone

What Is Finerenone Used For?

Brand name: Kerendia

Kerendia (finerenone) is used in adults with chronic kidney disease (CKD) linked to type 2 diabetes. It helps reduce the risk of kidney function decline, end-stage kidney disease, cardiovascular death, non-fatal heart attack, and hospitalization for heart failure in these patients.

Kerendia is also used in adults with heart failure who have a left ventricular ejection fraction (LVEF) — a measure of how well the heart pumps — of 40% or higher. In this group, it reduces the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits.

Most-Reported Side Effects for Finerenone

From FAERS, the FDA’s public side-effect reporting system (2,960 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Glomerular filtration rate decreased 308 reports

Hyperkalaemia 261 reports

Blood creatinine increased 226 reports

Blood potassium increased 180 reports

Renal impairment 140 reports

See full Finerenone drug information

Keep checking

Other Drugs & Greater Celandine

Browse every other medication we’ve checked against Greater Celandine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

625Moderate

0Minor

2,204No known interaction

625 Moderate 2,204 No interaction

Moderate

625 interactions

Showing 60 of 625 moderate interactions — see all 625 on the Greater Celandine page.

No interaction 2,204 drugs checked — show the list

We also checked Greater Celandine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,204 medications checked with no known interaction — see the full Greater Celandine list.

See the full Greater Celandine interactions page

See every supplement checked against Finerenone, ranked by severity

Evidence & sources

Greater Celandine References

The 25 references that drive our Greater Celandine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Benninger J, Schneider HT, Schuppan D, et al. Acute hepatitis induced by greater celandine (Chelidonium majus). Gastroenterology 1999;117:1234-7. PubMed
Holtmann G, Madisch A, Juergen H, et al. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. Ann Mtg Digestive Disease Week 1999 May.
Madisch A, Holtmann G, Mayr G, et al. Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion 2004;69:45-52. PubMed
Melzer J, Rosch W, Reichling J, et al. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther 2004;20:1279-87. PubMed
Ernst E, Schmidt K. Ukrain - a new cancer cure? A systematic review of randomised clinical trials. BMC Cancer 2005;5:69. PubMed
Stickel F, Poschl G, Seitz HK, et al. Acute hepatitis induced by Greater Celandine (Chelidonium majus). Scand J Gastroenterol 2003;38:565-8.
Etxenagusia MA, Anda M, Gonzalez-Mahave I, et al. Contact dermatitis from Chelidonium majus (greater celandine). Contact Dermatitis 2000;43:47.
Panzer A, Joubert AM, Bianchi PC, Seegers JC. The antimitotic effects of Ukrain, a Chelidonium majus alkaloid derivative, are reversible in vitro. Cancer Lett 2000;150:85-92. PubMed
Moro PA, Cassetti F, Giugliano G, et al. Hepatitis from greater celandine (Chelidonium majus L.): Review of literature and report of a new case. J Ethnopharmacol 2009;124:328-32. PubMed
Stickel, F., Seitz, H. K., Hahn, E. G., and Schuppan, D. [Liver toxicity of drugs of plant origin]. Z.Gastroenterol. 2001;39(3):225-227.
Gansauge, F., Ramadani, M., Pressmar, J., Gansauge, S., Muehling, B., Stecker, K., Cammerer, G., Leder, G., and Beger, H. G. NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial. Langenbecks Arch.Surg. 2002;38 PubMed
Nowicky, J. W., Manolakis, G., Meijer, D., Vatanasapt, V., and Brzosko, W. J. Ukrain both as an anti cancer and immunoregulatory agent. Drugs Exp.Clin Res 1992;18 Suppl:51-54.
Staniszewski, A., Slesak, B., Kolodziej, J., Harlozinska-Szmyrka, A., and Nowicky, J. W. Lymphocyte subsets in patients with lung cancer treated with thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (Ukrain). Drugs Exp.Clin Res 1992;18
Nowicky, J. W., Staniszewski, A., Zbroja-Sontag, W., Slesak, B., Nowicky, W., and Hiesmayr, W. Evaluation of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. ("Ukrain") as an immunostimulant in patients with various carcinomas. Drugs Ex
Gansauge, F., Ramadani, M., Schwarz, M., Beger, H. G., Lotspeich, E., and Poch, B. The clinical efficacy of adjuvant systemic chemotherapy with gemcitabine and NSC-631570 in advanced pancreatic cancer. Hepatogastroenterology 2007;54(75):917-920.
Hardeman, E., Van, Overbeke L., Ilegems, S., and Ferrante, M. Acute hepatitis induced by greater celandine (Chelidonium majus). Acta Gastroenterol.Belg. 2008;71(2):281-282.
Gilca, M., Gaman, L., Panait, E., Stoian, I., and Atanasiu, V. Chelidonium majus--an integrative review: traditional knowledge versus modern findings. Forsch.Komplementmed. 2010;17(5):241-248. PubMed
Teschke, R., Glass, X., and Schulze, J. Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): causality assessment of 22 spontaneous reports. Regul.Toxicol.Pharmacol. 2011;61(3):282-291. PubMed
Teschke, R., Glass, X., Schulze, J., and Eickhoff, A. Suspected Greater Celandine hepatotoxicity: liver-specific causality evaluation of published case reports from Europe. Eur.J Gastroenterol.Hepatol. 2012;24(3):270-280. PubMed
Pinto, Garcia, V, Vicente, P. R., Barez, A., Soto, I., Candas, M. A., and Coma, A. [Hemolytic anemia induced by Chelidonium majus. Clinical case]. Sangre (Barc.) 1990;35(5):401-403.
Teschke, R., Frenzel, C., Glass, X., Schulze, J., and Eickhoff, A. Greater Celandine hepatotoxicity: a clinical review. Ann.Hepatol. 2012;11(6):838-848. DOI
Xian, M. S., Hayashi, K., Lu, J. P., and Awai, M. Efficacy of traditional Chinese herbs on squamous cell carcinoma of the esophagus: histopathologic analysis of 240 cases. Acta Med.Okayama 1989;43(6):345-351.
Pantano F, Mannocchi G, Marinelli E, Gentili S, Graziano S, Busardò FP, di Luca NM. Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature. Eur Rev Med Pharmacol Sci. 2017 Mar;21(1 Suppl):46-52.
Baek SC, Ryu HW, Kang MG, et al. Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid. Bioorg Med Chem Lett. 2018;28(14):2403-2407. PubMed
Liu Y, Cui T, Peng Y, Ji M, Zheng J. Mechanism-based inactivation of cytochrome P450 2D6 by chelidonine. J Biochem Mol Toxicol. 2019;33(2):e22251. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Greater Celandine and Finerenone Together: Common Questions

Is it safe to take Greater Celandine with Finerenone?

We do not list a known interaction between Greater Celandine and Finerenone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Greater Celandine and Finerenone have any of the same side effects?

Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Greater Celandine and Finerenone combination checked?

Interactions in our licensed database are recorded against drug classes. Finerenone is filed under 3 classifications, and Greater Celandine has documented interactions with 4 drug classes — none of Finerenone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Greater Celandine interact with any other medications?

Yes. Greater Celandine has 625 documented drug interactions in our database — Finerenone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Finerenone interact with any supplements?

Yes. Finerenone has documented interactions with 146 supplements in our database — Greater Celandine is not one of them. The Finerenone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Greater Celandine monograph Uses, safety profile, and every drug interaction in one place Finerenone drug information The full plain-English guide to this medication Finerenone supplement interactions Every supplement checked against Finerenone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 25 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Finerenone and Greater Celandine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.