Drug & supplement interaction

Ground Pine + Buspirone

Buspirone brand name: BuSpar.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ground Pine and Buspirone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ground Pine and Buspirone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Buspirone and Ground Pine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ground Pine at all — not against Buspirone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ground Pine safety at a glance

Ground Pine overall Use caution Little modern safety data exists, so use cautiously and only under guidance.
Pregnancy Avoid Traditionally linked to menstrual stimulation, so avoid during pregnancy.
Breastfeeding Avoid No safety data in breastfeeding, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Buspirone and Ground Pine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Buspirone’s Own FDA Label Lists

This is not an interaction — none of it involves Ground Pine. These are the most notable effects listed in the ADVERSE REACTIONS section of Buspirone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Serotonin syndrome Worth acting on
  • Thoughts of self-harm Worth acting on
  • A stroke or mini-stroke Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Muscle weakness Worth acting on
  • Trouble passing urine Worth acting on
  • A slow heartbeat Worth acting on
  • A heart attack Worth acting on
  • Hallucinations Worth acting on
  • Heart failure Worth acting on

Showing the 10 most notable of 64 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed › Ground Pine’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Ground Pine side to compare — that is a limit of the record, not a statement that Ground Pine has no side effects.

From our Q&A

Questions About Ground Pine or Buspirone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ground Pine or Buspirone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Buspirone

This page covers Ground Pine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Buspirone page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 5-htp (moderate).

By severity: 4 major · 108 moderate · 43 minor.

From our pharmacist’s overview on the Buspirone page

“I counsel genuine caution when supplements meet buspirone (BuSpar), the anxiety medication, because four of its 155 documented interactions are rated major. The bulk of the list, 121 ingredients, changes how your liver clears buspirone through the CYP3A4 enzyme, pushing its level up toward dizziness and drowsiness or down until the anx…”

Reviewed by 2 · Jul 18, 2026

Open the Buspirone interaction page

How much people look this up

Where Ground Pine and Buspirone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ground Pine
Steady interest

#743 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Buspirone
Top 5%

#53 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Ground Pine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ground Pine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ground Pine and Buspirone records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ground Pine

What is Ground Pine?

  • Joint pain and gout
  • Mild fever
  • Menstrual complaints
  • Wound and skin care
  • Digestive upset

Ground Pine (Ajuga chamaepitys) is a traditional European herb used mainly for joint pain, gout, and menstrual problems, but there is very little modern scientific evidence to support these uses. Because its safety has not been well studied, it should be used cautiously, and it should be avoided in pregnancy and breastfeeding. Talk to a pharmacist or doctor before trying it.

Ajuga chamaepitys · Lamiaceae · Aerial parts (flowering tops, leaves, and stems) · Dried herb, tea/infusion, tincture, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Ground Pine is a good idea for someone in your situation. Here is what our Ground Pine record says about it on its own.

Ground Pine: dosing

There is no established, standardized dose for Ground Pine. It has not been studied enough in modern research to define a safe and effective amount.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Ground Pine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ground Pine monograph & all interactions
Medication

About Buspirone

What Is Buspirone Used For?

Brand name: BuSpar

Buspirone tablets and capsules are used to manage anxiety disorders or to relieve anxiety symptoms in the short term. Its effectiveness has been shown in clinical trials focused on Generalized Anxiety Disorder (GAD) — a condition marked by persistent, hard-to-control worry along with physical symptoms like muscle tension, restlessness, difficulty concentrating, and sleep problems.

Buspirone has also been shown to relieve anxiety in people who have mild depressive symptoms alongside their anxiety. Everyday stress and tension, on their own, generally do not require treatment with a medicine like buspirone.

See full Buspirone drug information
Keep checking

Other Drugs & Ground Pine

Browse every other medication we’ve checked against Ground Pine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ground Pine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ground Pine list.

See the full Ground Pine interactions page
See every supplement checked against Buspirone, ranked by severity
Evidence & sources

Ground Pine References

The 2 sources that drive our Ground Pine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Ground Pine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
  2. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ground Pine and Buspirone Together: Common Questions

Is it safe to take Ground Pine with Buspirone?
We do not list a known interaction between Ground Pine and Buspirone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Buspirone interact with any supplements?
Yes. Buspirone has documented interactions with 155 supplements in our database — Ground Pine is not one of them. The Buspirone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ground Pine monograph Uses, safety profile, and every drug interaction in one place Buspirone drug information The full plain-English guide to this medication Buspirone supplement interactions Every supplement checked against Buspirone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Buspirone and Ground Pine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.