Drug & supplement interaction

Guar Gum + Mipomersen Sodium

Mipomersen Sodium brand name: Kynamro.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Guar Gum and Mipomersen Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Guar Gum and Mipomersen Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mipomersen Sodium and Guar Gum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Guar Gum safety at a glance

Guar Gum overall Use caution Generally safe as a food, but supplements must be taken with lots of water to avoid choking or blockage.

Pregnancy Possibly Safe When used orally and appropriately in medicinal amounts. Guar gum has been safely used at doses of 5-15 grams daily for up to 4 weeks during pregnancy. Read the full pregnancy detail

Breastfeeding Use caution Little safety data on supplement doses, so it is best to be cautious and ask your doctor.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mipomersen Sodium and Guar Gum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Mipomersen Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mipomersen Sodium is filed under a single classification — hepatotoxic drugs. Guar Gum has documented interactions with 5 drug classes — the most serious being ethinyl estradiol (moderate), metformin (glucophage) (moderate) and oral drugs (moderate) — and none of Mipomersen Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Guar Gum Does Interact With Other Medications

Guar Gum has 2,025 moderate known drug interactions in our database — Mipomersen Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2,025 No known interaction 805 (incl. Mipomersen Sodium)

Taking anything else?

Check Another of Your Medications Against Guar Gum

Covers the 2,830 medications we’ve checked against Guar Gum. Pick one to open its full report.

What to actually watch for

What Guar Gum Itself Has Been Linked To

This is not an interaction — nothing below involves Mipomersen Sodium. It is the side-effect record for Guar Gum on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Guar Gum, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

A bowel blockage Worth acting on Additional detail
“Orally, guar gum may cause gastrointestinal adverse effects such as abdominal cramps, abdominal pain, bloating, diarrhea, flatulence, heartburn, gas, and loose stools. Gastrointestinal side effects can be minimized by starting with small doses and titrating up.”

Guar Gum · Natural Medicines adverse-effect record, reported in diarrhea.
6 sources cited

10896. Vuorinen-Markkola H, Sinisalo M, Koivisto VA. Guar gum in insulin-dependent diabetes: effects on glycemic control and serum lipoproteins. Am J Clin Nutr 1992;56:1056-1060. PubMed

10897. Superko HR, Haskell WL, Sawrey-Kubicek L, Farquhar JW. Effects of solid and liquid guar gum on plasma cholesterol and triglyceride concentrations in moderate hypercholesterolemia. Am J Cardiol 1988;62:51-5. PubMed

12541. Groop PH, Aro A, Stenman S, Groop L. Long-term effects of guar gum in subjects with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1993;58:513-8. PubMed

12543. Chuang LM, Jou TS, Yang WS, et al. Therapeutic effect of guar gum in patients with non-insulin-dependent diabetes mellitus. J Formos Med Assoc 1992;91:15-9.

12545. Ebeling P, Yki-Jarvinen H, Aro A, et al. Glucose and lipid metabolism and insulin sensitivity in type 1 diabetes: the effect of guar gum. Am J Clin Nutr 1988;48:98-103. PubMed

12547. Knopp RH, Superko HR, Davidson M, et al. Long-term blood cholesterol-lowering effects of a dietary fiber supplement. Am J Prev Med 1999;17:18-23. PubMed
Wheezing Worth acting on Additional detail
“Occupational exposure to guar gum may cause asthma.”

Guar Gum · Natural Medicines adverse-effect record, reported in asthma.
2 sources cited

600. Malo JL, Cartier A, L'Archeveque J, et al. Prevalence of occupational asthma and immunologic sensitization to guar gum among employees at a carpet-manufacturing plant. J Allergy Clin Immunol 1990;86:562-9. PubMed

601. Lagier F, Cartier A, Somer J, et al. Occupational asthma caused by guar gum. J Allergy Clin Immunol 1990;85:785-90.
Heartburn / Bloating or gas / Stomach pain / Diarrhea Additional detail

Recorded for Guar Gum in the same Natural Medicines adverse-effect record shown under A bowel blockage above.

Everything above comes from the Natural Medicines adverse-effect record for Guar Gum — expand a row for the licensed statement it rests on. We haven’t matched Mipomersen Sodium to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Mipomersen Sodium.

Special populations

Guar Gum in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally and appropriately in medicinal amounts. Guar gum has been safely used at doses of 5-15 grams daily for up to 4 weeks during pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Mipomersen Sodium Is Prescribed For, and What Guar Gum Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Mipomersen Sodium is a prescription medicine with approved uses on its FDA label. Guar Gum is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Guar Gum has been studied for:

Hypercholesterolemia Natural Medicines rates the evidence for Guar Gum: Possibly Effective Read what the research shows

Guar Gum for hypercholesterolemia

Oral guar gum, taken alone or with other dietary fibers, may reduce cholesterol levels in patients with hypercholesterolemia.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Mipomersen Sodium on your own; if you are taking Guar Gum for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Mipomersen Sodium

This page covers Guar Gum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mipomersen Sodium page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Ashwagandha (moderate) and Black Cohosh (moderate).

By severity: 3 major · 35 moderate.

From our pharmacist’s overview on the Mipomersen Sodium page

“Kynamro (mipomersen sodium) treats a severe inherited cholesterol disorder, and it already carries a serious warning about liver injury on its own. All 38 supplements and herbs on this page interact the same way, by adding their own liver stress to a medicine that is hard on that organ to begin with, so approach this list with genuine…”

Reviewed by 2 · Jul 18, 2026

Open the Mipomersen Sodium interaction page

One more smart check

Taking Guar Gum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 33 real supplement products containing Guar Gum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Guar Gum. Even though Guar Gum itself has no known interaction with Mipomersen Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Guar Gum and Mipomersen Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Guar Gum

Top half

#451 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Mipomersen Sodium

Steady interest

#1,644 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Guar Gum reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Guar Gum and Mipomersen Sodium records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Guar Gum

What is Guar Gum?

Constipation and bowel regularity
Diarrhea (as a stool bulking agent)
Lowering cholesterol
Blood sugar control
Feeling full for weight management

Guar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity. It is generally safe in food amounts, but concentrated supplements can cause gas, bloating, and a risk of throat or gut blockage if not taken with enough water. Always take it with plenty of fluid and check with your pharmacist or doctor first.

Cyamopsis tetragonoloba · Fabaceae · Seeds (endosperm) · Powder, capsules, tablets, partially hydrolyzed guar gum (in some fiber drinks); also a food additive

An interaction check asks whether these two react with each other — it does not ask whether Guar Gum is a good idea for someone in your situation. Here is what our Guar Gum record says about it on its own.

Guar Gum: dosing

There is no single official dose for guar gum as a supplement. The right amount depends on the product and why you are taking it.The best approach is to follow the directions on the product label and start with a low amount.

From our Guar Gum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Guar Gum monograph & all interactions

Medication

About Mipomersen Injection

What Is Mipomersen Injection Used For?

Brand name: Kynamro

Mipomersen injection is used to decrease levels of cholesterol and other fatty substances in the blood in people who have homozygous familial hypercholesterolemia (HoFH; a rare inherited condition that causes very high levels of cholesterol in the blood, increasing the risk of serious heart disease). Some people with HoFH may be treated with LDL apheresis (a procedure that removes LDL from the blood), but mipomersen injection should not be used along with this treatment. Mipomersen injection should not be used to decrease cholesterol levels in people who do not have HoFH. Mipomersen injection is in a class of medications called antisense oligonucleotide (ASO) inhibitors. It works by preventing certain fatty substances from forming in the body.

See full Mipomersen Injection drug information

Keep checking

Other Drugs & Guar Gum

Browse every other medication we’ve checked against Guar Gum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

2,025Moderate

0Minor

804No known interaction

2,025 Moderate 804 No interaction

Moderate

2,025 interactions

Showing 60 of 2,025 moderate interactions — see all 2,025 on the Guar Gum page.

No interaction 804 drugs checked — show the list

We also checked Guar Gum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 804 medications checked with no known interaction — see the full Guar Gum list.

See the full Guar Gum interactions page

See every supplement checked against Mipomersen Sodium, ranked by severity

Evidence & sources

Guar Gum References

The 26 references that drive our Guar Gum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Gin H, Orgerie MB, Aubertin J. The influence of Guar gum on absorption of metformin from the gut in healthy volunteers. Horm Metab Res 1989;21:81-3.
Huupponen R, Seppala P, Iisalo E. Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man. Eur J Clin Pharmacol 1984;26:279-81. PubMed
Malo JL, Cartier A, L'Archeveque J, et al. Prevalence of occupational asthma and immunologic sensitization to guar gum among employees at a carpet-manufacturing plant. J Allergy Clin Immunol 1990;86:562-9. PubMed
Lagier F, Cartier A, Somer J, et al. Occupational asthma caused by guar gum. J Allergy Clin Immunol 1990;85:785-90.
Lewis JH. Esophageal and small bowel obstruction from guar gum-containing diet pills: analysis of 26 cases reported to the FDA. Am J Gastroenterol 1992;87:1424-8.
Vuorinen-Markkola H, Sinisalo M, Koivisto VA. Guar gum in insulin-dependent diabetes: effects on glycemic control and serum lipoproteins. Am J Clin Nutr 1992;56:1056-1060. PubMed
Superko HR, Haskell WL, Sawrey-Kubicek L, Farquhar JW. Effects of solid and liquid guar gum on plasma cholesterol and triglyceride concentrations in moderate hypercholesterolemia. Am J Cardiol 1988;62:51-5. PubMed
Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
Groop PH, Aro A, Stenman S, Groop L. Long-term effects of guar gum in subjects with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1993;58:513-8. PubMed
Chuang LM, Jou TS, Yang WS, et al. Therapeutic effect of guar gum in patients with non-insulin-dependent diabetes mellitus. J Formos Med Assoc 1992;91:15-9.
Ebeling P, Yki-Jarvinen H, Aro A, et al. Glucose and lipid metabolism and insulin sensitivity in type 1 diabetes: the effect of guar gum. Am J Clin Nutr 1988;48:98-103. PubMed
Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 1996;30:359-71. PubMed
Knopp RH, Superko HR, Davidson M, et al. Long-term blood cholesterol-lowering effects of a dietary fiber supplement. Am J Prev Med 1999;17:18-23. PubMed
Patrick PG, Gohman SM, Marx SC, et al. Effect of supplements of partially hydrolyzed guar gum on the occurrence of constipation and use of laxative agents. J Am Diet Assoc 1998;98:912-4. PubMed
Osterlund P, Ruotsalainen T, Korpela R, et al. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br J Cancer 2007;97:1028-34. PubMed
Lembcke B, Hasler K, Kramer P, et al. Plasma digoxin concentrations during administration of dietary fibre (guar gum) in man. Z Gastroenterol 1982;20;164-7.
Riikonen, S., Savonius, H., Gylling, H., Nikkila, K., Tuomi, A. M., and Miettinen, T. A. Oral guar gum, a gel-forming dietary fiber relieves pruritus in intrahepatic cholestasis of pregnancy. Acta Obstet.Gynecol.Scand. 2000;79(4):260-264. DOI
Kovacs, E. M., Westerterp-Plantenga, M. S., Saris, W. H., Goossens, I., Geurten, P., and Brouns, F. The effect of addition of modified guar gum to a low-energy semisolid meal on appetite and body weight loss. Int.J.Obes.Relat Metab Disord. 2001;25(3):307 PubMed
Halama, W. H. and Mauldin, J. L. Distal esophageal obstruction due to a guar gum preparation (Cal-Ban 3000). South.Med.J. 1992;85(6):642-645. PubMed
Landin, K., Holm, G., Tengborn, L., and Smith, U. Guar gum improves insulin sensitivity, blood lipids, blood pressure, and fibrinolysis in healthy men. Am.J.Clin.Nutr. 1992;56(6):1061-1065. PubMed
Cicero, A. F., Derosa, G., Manca, M., Bove, M., Borghi, C., and Gaddi, A. V. Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a six-month, randomized clinical trial. Clin.Exp.Hyp PubMed
Simons LA, Gayst S, Balasubramaniam S, Ruys J. Long-term treatment of hypercholesterolaemia with a new palatable formulation of guar gum. Atherosclerosis 1982;45:101-108. PubMed
Salenius JP, Harju E, Jokela H, et al. Long term effects of guar gum on lipid metabolism after carotid endarterectomy. BMJ 1-14-1995;310:95-96. PubMed
Gylling, H., Riikonen, S., Nikkila, K., Savonius, H., and Miettinen, T. A. Oral guar gum treatment of intrahepatic cholestasis and pruritus in pregnant women: effects on serum cholestanol and other non-cholesterol sterols. Eur.J.Clin.Invest 1998;28(5):35 PubMed
Brillantino A, Iacobellis F, Izzo G, et al. Maintenance therapy with partially hydrolyzed guar gum in the conservative treatment of chronic anal fissure: results of a prospective, randomized study. Biomed Res Int 2014;2014:964942. PubMed
Polymeros D, Beintaris I, Gaglia A, et al. Partially hydrolyzed guar gum accelerates colonic transit time and improves symptoms in adults with chronic constipation. Dig Dis Sci 2014;59(9):2207-14. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Guar Gum and Mipomersen Sodium Together: Common Questions

Is it safe to take Guar Gum with Mipomersen Sodium?

We do not list a known interaction between Guar Gum and Mipomersen Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Guar Gum and Mipomersen Sodium used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Guar Gum in each. That is a conversation for your prescriber, especially if Mipomersen Sodium is being adjusted to a target.

How was the Guar Gum and Mipomersen Sodium combination checked?

Interactions in our licensed database are recorded against drug classes. Mipomersen Sodium is filed under 1 classification, and Guar Gum has documented interactions with 5 drug classes — none of Mipomersen Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Guar Gum interact with any other medications?

Yes. Guar Gum has 2,025 documented drug interactions in our database — Mipomersen Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Mipomersen Sodium interact with any supplements?

Yes. Mipomersen Sodium has documented interactions with 38 supplements in our database — Guar Gum is not one of them. The Mipomersen Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Guar Gum monograph Uses, safety profile, and every drug interaction in one place Mipomersen Injection drug information The full plain-English guide to this medication Mipomersen Sodium supplement interactions Every supplement checked against Mipomersen Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 26 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mipomersen Sodium and Guar Gum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.