Drug & supplement interaction

Hawaiian Baby Woodrose + Sumatriptan

Sumatriptan brand name: Tosymra.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Hawaiian Baby Woodrose has a moderate interaction with Sumatriptan. Theoretically, concomitant use may increase the risk for serotonergic adverse effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Hawaiian Baby Woodrose and Sumatriptan

Here is the interaction we found between these two, with the evidence behind it.

Moderate

SEROTONERGIC DRUGS

Why this applies to Sumatriptan

Sumatriptan falls under SEROTONERGIC DRUGS — the group Hawaiian Baby Woodrose interacts with.

Theoretically, concomitant use may increase the risk for serotonergic adverse effects.
Hawaiian baby woodrose contains chemicals which might increase serotonin levels. Combining serotonergic drugs with Hawaiian baby woodrose might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the concern with mixing these two. Sumatriptan works by activating serotonin receptors in your brain to stop a migraine. Hawaiian Baby Woodrose seeds contain LSD-like compounds (LSA) that also push hard on those same serotonin pathways. Stacking two things that ramp up serotonin can, in theory, raise your risk of serotonin syndrome, which can look like agitation, a racing heart, sweating, shivering, muscle twitching, or confusion. Both also narrow blood vessels, so combining them could add to chest tightness, flushing, or that pressure feeling some people get with sumatriptan.

I'll be honest: this warning is theoretical, based on how these compounds behave rather than real case reports. Still, the seeds carry serious safety risks on their own, so I'd steer clear and talk with your pharmacist or doctor before going anywhere near this combo.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Hawaiian Baby Woodrose Also Interacts With Other Medications

Hawaiian Baby Woodrose has 183 moderate known drug interactions in our database — the Sumatriptan one above is one of them. If you take anything else, check it against the full list below.

Moderate 183 No known interaction 2,647 (incl. Sumatriptan)
Taking anything else?

Check Another of Your Medications Against Hawaiian Baby Woodrose

Covers the 2,830 medications we’ve checked against Hawaiian Baby Woodrose. Pick one to open its full report.

From our Q&A

Questions About Hawaiian Baby Woodrose or Sumatriptan

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hawaiian Baby Woodrose or Sumatriptan, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sumatriptan

This page covers Hawaiian Baby Woodrose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sumatriptan page lists 50 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 31 moderate · 11 minor.

From our pharmacist’s overview on the Sumatriptan page

“The supplement risk that matters most with sumatriptan (Tosymra) is serotonin overload. This migraine drug works through serotonin receptors, and 20 of the 50 interacting ingredients on file, 5-HTP among them, can push serotonin activity higher still, raising the risk of serotonin syndrome (agitation, racing heart, fever).”

Reviewed by 2 · Jul 18, 2026

Open the Sumatriptan interaction page

How much people look this up

Where Hawaiian Baby Woodrose and Sumatriptan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hawaiian Baby Woodrose
Steady interest

#1,438 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sumatriptan
Top 5%

#50 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Hawaiian Baby Woodrose

What is Hawaiian Baby Woodrose?

Hawaiian Baby Woodrose
  • Hallucinogenic/psychedelic effects (recreational)
  • Pain relief (traditional)
  • Anti-inflammatory (traditional)
  • Aphrodisiac (traditional Ayurvedic use)
  • Nervous system tonic (traditional)

Hawaiian Baby Woodrose seeds contain LSD-like compounds and are most often used recreationally to cause hallucinations, not as a safe or proven medicine. Because of serious safety risks, unpredictable effects, and unclear legal status, it is generally not recommended. If you are considering any product containing it, talk to a pharmacist or doctor first.

Read the full Hawaiian Baby Woodrose monograph & all interactions
Medication

About Sumatriptan

What Is Sumatriptan Used For?

Brand name: Tosymra

Sumatriptan treats acute migraine attacks — with or without aura — in adults. It is available as tablets, nasal spray, nasal capsule, and subcutaneous injection, and is used to stop a migraine once it has started, not to prevent future attacks.

The subcutaneous injection forms — including Imitrex injection, Sumatriptan injection, and Sumatriptan Succinate injection — are also approved to treat acute cluster headache in adults. Zembrace SymTouch (subcutaneous injection) is approved for acute migraine only. Tablets and nasal forms are not established for cluster headache.

See full Sumatriptan drug information
Keep checking

Other Drugs & Hawaiian Baby Woodrose

Browse every other medication we’ve checked against Hawaiian Baby Woodrose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
183Moderate
0Minor
2,646No known interaction
183 Moderate 2,646 No interaction
Moderate

183 interactions

Showing 60 of 183 moderate interactions — see all 183 on the Hawaiian Baby Woodrose page.

No interaction 2,646 drugs checked — show the list

We also checked Hawaiian Baby Woodrose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,646 medications checked with no known interaction — see the full Hawaiian Baby Woodrose list.

See the full Hawaiian Baby Woodrose interactions page
See every supplement checked against Sumatriptan, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Hawaiian Baby Woodrose monograph › Uses, safety, and every drug interaction in one place Sumatriptan supplement interactions › Every supplement checked against Sumatriptan, ranked by severity Sumatriptan drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Hawaiian Baby Woodrose and Sumatriptan Together: Common Questions

Can you take Hawaiian Baby Woodrose with Sumatriptan?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Hawaiian Baby Woodrose and Sumatriptan interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Sumatriptan and Hawaiian Baby Woodrose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.