Drug & supplement interaction

Hedge-hyssop + Trospium

Trospium brand names: Sanctura, Trosec, Regurin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Hedge-hyssop and Trospium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Trospium states a food rule worth keeping to.

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Interaction report

Hedge-hyssop and Trospium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trospium and Hedge-hyssop in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hedge-hyssop at all — not against Trospium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hedge-hyssop safety at a glance

Hedge-hyssop overall Avoid Hedge-hyssop is considered toxic and can cause severe gastrointestinal and systemic poisoning.
Pregnancy Unsafe When used orally due to toxic potential. Read the full pregnancy detail
Breastfeeding Unsafe When used orally due to toxic potential. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trospium and Hedge-hyssop? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Hedge-hyssop Itself Has Been Linked To

This is not an interaction — nothing below involves Trospium. It is the side-effect record for Hedge-hyssop on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Hedge-hyssop, this list is the first place to look.

  • Passing urine more often / Diarrhea / Vomiting Additional detail

    “Orally, taken in toxic doses, hedge-hyssop may cause vomiting, bloody diarrhea, colic, and kidney irritation characterized by initial diuresis followed by anuria. When people ingest very large amounts, spasms, paralysis, and circulatory collapse occur. Death occurs rarely (18).”

    Hedge-hyssop · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Hedge-hyssop — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Trospium’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Trospium column appears here.

Special populations

Hedge-hyssop in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally due to toxic potential.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Trospium Products Have a Food Rule — Hedge-hyssop Should Not Break It

At least one FDA label for a product containing Trospium says to take it on an empty stomach. Most supplements — Hedge-hyssop included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Trospium on its own and move Hedge-hyssop to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Trospium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Trospium Chloride Extended-Release Capsules should be dosed with water on an empty stomach, at least one hour before a meal.

From the Dosage and Administration section of the FDA label we read for Trospium — where that label names a specific product, the instruction is that product's. See the Trospium drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Trospium

This page covers Hedge-hyssop only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trospium page lists 47 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).

By severity: 3 major · 33 moderate · 11 minor.

From our pharmacist’s overview on the Trospium page

“Trospium (Sanctura, Regurin) calms an overactive bladder by blocking acetylcholine, and most of the 47 supplements flagged against it press on that same nerve signal. Thirty carry anticholinergic activity of their own, adding dry mouth, constipation, blurred vision, and confusion, and two of the three major ratings sit in that group: h…”

Reviewed by 2 · Jul 18, 2026

Open the Trospium interaction page

How much people look this up

Where Hedge-hyssop and Trospium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hedge-hyssop
Steady interest

#1,211 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trospium
Steady interest

#2,205 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hedge-hyssop reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hedge-hyssop and Trospium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hedge-hyssop

What is Hedge-hyssop?

  • Constipation and as a laxative
  • Fluid retention (diuretic use)
  • Liver and digestive complaints
  • Skin conditions (traditional/topical)
  • Inducing vomiting (historical purgative)

Hedge-hyssop is a traditional European herb that was historically used as a strong laxative, diuretic, and purgative, but it is considered toxic and is not recommended for self-treatment. There is no reliable modern evidence that it is safe or effective, and serious poisoning has been reported, so it is best avoided.

Gratiola officinalis · Plantaginaceae · Aerial parts (leaves and flowering stems), sometimes the root · Dried herb, tincture, and historically homeopathic preparations

An interaction check asks whether these two react with each other — it does not ask whether Hedge-hyssop is a good idea for someone in your situation. Here is what our Hedge-hyssop record says about it on its own.

Hedge-hyssop: dosing

There is no established safe or standardized dose of hedge-hyssop. Because the plant is toxic and the margin between a traditional dose and a harmful dose is narrow, no specific amount can be recommended.We do not advise self-treating with this herb.

From our Hedge-hyssop monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hedge-hyssop monograph & all interactions
Medication

About Trospium

What Is Trospium Used For?

Brand names: Sanctura, Trosec, Regurin

Trospium — available as tablets and extended-release capsules — is used to treat overactive bladder (OAB). It targets three main symptoms: the sudden, hard-to-control urge to urinate (urgency), leaking urine when that urge hits (urge urinary incontinence), and needing to urinate much more often than usual (urinary frequency).

Both Trospium Chloride Tablets and Trospium Chloride Extended-Release Capsules carry this indication. Your prescriber will choose the formulation that fits your schedule and health history.

See full Trospium drug information
Keep checking

Other Drugs & Hedge-hyssop

Browse every other medication we’ve checked against Hedge-hyssop — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Hedge-hyssop against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hedge-hyssop list.

See the full Hedge-hyssop interactions page
See every supplement checked against Trospium, ranked by severity
Evidence & sources

Hedge-hyssop References

The 1 references that drive our Hedge-hyssop monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hedge-hyssop and Trospium Together: Common Questions

Is it safe to take Hedge-hyssop with Trospium?
We do not list a known interaction between Hedge-hyssop and Trospium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Hedge-hyssop and Trospium at the same time of day?
At least one FDA label for a product containing Trospium says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Trospium on its own and move Hedge-hyssop to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Trospium interact with any supplements?
Yes. Trospium has documented interactions with 47 supplements in our database — Hedge-hyssop is not one of them. The Trospium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hedge-hyssop monograph Uses, safety profile, and every drug interaction in one place Trospium drug information The full plain-English guide to this medication Trospium supplement interactions Every supplement checked against Trospium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trospium and Hedge-hyssop?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.