Drug & supplement interaction

Honey + Minocycline Hydrochloride

Minocycline Hydrochloride brand names: Ximino, Minolira.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Honey and Minocycline Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Honey and Minocycline Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Minocycline Hydrochloride and Honey in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Honey safety at a glance

Honey overall Generally safe Generally safe as a food for adults and children over 1 year of age.

Pregnancy Likely Safe When consumed in food amounts. The concern about botulism pertains to children under 12 months of age and not to pregnant adults. There is insufficient reliable... Read the full pregnancy detail

Breastfeeding Likely Safe When consumed in food amounts. The concern about botulism pertains to children under 12 months of age and not to pregnant adults. There is insufficient reliable... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Minocycline Hydrochloride and Honey? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Minocycline Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Minocycline Hydrochloride is filed under 7 classifications — including tetracycline antibiotics, antibiotic drugs, p-glycoprotein substrates. Honey has documented interactions with 3 drug classes — the most serious being phenytoin (dilantin) (moderate), anticoagulant/antiplatelet drugs (minor) and cytochrome p450 3a4 (cyp3a4) substrates (minor) — and none of Minocycline Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Honey Does Interact With Other Medications

Honey has 5 moderate, 731 minor known drug interactions in our database — Minocycline Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 5 Minor 731 No known interaction 2,094 (incl. Minocycline Hydrochloride)

Taking anything else?

Check Another of Your Medications Against Honey

Covers the 2,830 medications we’ve checked against Honey. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Honey and Minocycline Hydrochloride May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

An allergic reaction Worth acting on reported in 13.8% of FDA reports for Minocycline Hydrochloride Additional detail
Honey
“Orally, honey can cause allergic reactions, including anaphylaxis (6,11,108531,108532). These reactions may be due to various components of the honey, including the honey itself, pollen, or bee secretions. When used topically, local allergic reactions have been reported in people with pre-existing atopy. Allergic contact dermatitis related to honey enriched with propolis has been reported.”

Honey · Natural Medicines adverse-effect record, reported in atopic disease.
6 sources cited

6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

108531. Jhawar N, Gonzalez-Estrada A. Honey-induced anaphylaxis in an adult. QJM 2022;115(5):325-326. PubMed

108532. Di Costanzo M, De Paulis N, Peveri S, Montagni M, Berni Canani R, Biasucci G. Anaphylaxis caused by artisanal honey in a child: a case report. J Med Case Rep 2021;15(1):235. PubMed

91370. Vezir E, Kaya A, Toyran M, Azkur D, Dibek Misirlioglu E, Kocabas CN. Anaphylaxis/angioedema caused by honey ingestion. Allergy Asthma Proc. 2014 Jan-Feb;35(1):71-4. PubMed

16356. Simon A, Traynor K, Santos K, et al. Medical honey for wound care - still the 'latest resort'? Evid Based Complement Alternat Med 2009;6:165-73. PubMed
Minocycline Hydrochloride

Listed in the ADVERSE REACTIONS section of the FDA label for Minocycline Hydrochloride, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
A severe allergic reaction Worth acting on Additional detail

Honey

“Orally and topically, honey is generally well tolerated in those at least 1 year of age. When given intranasally or into the eyes, honey seems to be well tolerated. However, honey containing grayanotoxins, which are found in rhododendrons, is likely unsafe and should be avoided.

Most Common Adverse Effects:

Orally: Nausea, stomach pain, and vomiting.

Topically: Burning, pain, and stinging.

Intranasally: Burning and n…”

Honey · Natural Medicines adverse-effect record, reported in arrhythmia.

Minocycline Hydrochloride

Listed in the ADVERSE REACTIONS section of the FDA label for Minocycline Hydrochloride. Read the label on DailyMed ›
A skin rash reported in 14.1% of FDA reports for Minocycline Hydrochloride Additional detail

Honey

Recorded for Honey in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

Minocycline Hydrochloride

Listed in the ADVERSE REACTIONS section of the FDA label for Minocycline Hydrochloride, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
Nausea / Vomiting reported in 14.5% of FDA reports for Minocycline Hydrochloride Additional detail
Honey
“Orally, honey may cause mild nausea, vomiting, and stomach ache. Honey from the Black Sea coast of Turkey has been linked with a unique form of poisoning. Honey from this region sometimes contains excessive concentrations of grayanotoxins. These toxins can cause increased salivation, nausea, and vomiting within a few minutes to several hours after consumption. Intranasally, honey may cause nausea.”

Honey · Natural Medicines adverse-effect record, reported in nausea and vomiting.
6 sources cited

12220. Ozhan H, Akdemir R, Yazici M, et al. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. PubMed

55119. Koca, I. and Koca, A. F. Poisoning by mad honey: a brief review. Food Chem Toxicol 2007;45(8):1315-1318. PubMed

55190. Shrestha, P., Vaidya, R., and Sherpa, K. Mad honey poisoning: a rare case report of seven cases. Nepal Med Coll J 2009;11(3):212-213.

55294. Sutlupinar, N., Mat, A., and Satganoglu, Y. Poisoning by toxic honey in Turkey. Arch.Toxicol. 1993;67(2):148-150. PubMed

97693. Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM. Honey for acute cough in children. Cochrane Database Syst Rev. 2018;4:CD007094. PubMed

55216. Thamboo, A., Thamboo, A., Philpott, C., Javer, A., and Clark, A. Single-blind study of manuka honey in allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg 2011;40(3):238-243.
Minocycline Hydrochloride

Listed in the ADVERSE REACTIONS section of the FDA label for Minocycline Hydrochloride, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
Dizziness Additional detail
Honey
“Orally, honey may cause nervousness, insomnia, and hyperactivity in children. Honey from the Black Sea coast of Turkey has been linked with a unique form of poisoning. Honey from this region sometimes contains excessive concentrations of grayanotoxins, which can cause dizziness, sweating, and weakness within a few minutes to several hours after consumption.”

Honey · Natural Medicines adverse-effect record, reported in insomnia.
6 sources cited

91366. Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014 Dec 23;12:CD007094. PubMed

97693. Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM. Honey for acute cough in children. Cochrane Database Syst Rev. 2018;4:CD007094. PubMed

12220. Ozhan H, Akdemir R, Yazici M, et al. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. PubMed

55110. Gunduz, A., Turedi, S., Uzun, H., and Topbas, M. Mad honey poisoning. Am J Emerg.Med 2006;24(5):595-598.

55119. Koca, I. and Koca, A. F. Poisoning by mad honey: a brief review. Food Chem Toxicol 2007;45(8):1315-1318. PubMed

55296. von Malottki, K. and Wiechmann, H. W. [Acute life-threatening bradycardia: food poisoning by Turkish wild honey]. Dtsch.Med.Wochenschr. 7-26-1996;121(30):936-938.
Minocycline Hydrochloride

Listed in the ADVERSE REACTIONS section of the FDA label for Minocycline Hydrochloride. Read the label on DailyMed ›

Reported for Honey but not commonly for Minocycline Hydrochloride: a heart attack, an irregular heartbeat, stomach pain and anxiety or restlessness.

Effects for Minocycline Hydrochloride come from the ADVERSE REACTIONS section of its FDA label; effects for Honey come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 5,809 voluntary FDA FAERS reports for Minocycline Hydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Honey in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When consumed in food amounts. The concern about botulism pertains to children under 12 months of age and not to pregnant adults. There is insufficient reliable information available about the safety of honey when used for medicinal purposes when pregnant or breast-feeding.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Minocycline Hydrochloride Is Prescribed For, and What Honey Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Minocycline Hydrochloride is a prescription medicine with approved uses on its FDA label. Honey is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Minocycline Hydrochloride is prescribed for: Oral and intravenous minocycline products treat many serious bacterial infections, including Rocky Mountain spotted fever, respiratory tract infections, sexually transmitted infections such as lymphogranuloma venereum and nongonococcal urethritis, plague, cholera, brucellosis, tularemia, and others caused by susceptible organisms. MINOCIN Intravenous is used when oral therapy is not adequate or tolerated. Extended-release oral minocycline tablets are indicated specifically for inflammatory lesions of moderate to severe acne vulgaris in patients 12 years and older — not for treating infections. AMZEEQ (topical foam) treats inflammatory lesions of moderate to severe acne vulgaris in patients 9 years and older.

Read the rest of what Minocycline Hydrochloride is prescribed for

ZILXI (topical foam) and EMROSI (oral capsule) are indicated for inflammatory lesions of rosacea in adults. ARESTIN (oral powder placed by a dental professional) is used alongside scaling and root planing to reduce pocket depth in adult periodontitis.

Honey has been studied for:

Rosacea Natural Medicines rates the evidence for Honey: Possibly Effective Read what the research shows

Honey for rosacea

Topical honey seems to be beneficial for rosacea.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Minocycline Hydrochloride on your own; if you are taking Honey for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Honey or Minocycline Hydrochloride

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Honey or Minocycline Hydrochloride, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Minocycline Hydrochloride

This page covers Honey only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Minocycline Hydrochloride page lists 161 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Oleander (major) and Siberian Cocklebur (major).

By severity: 7 major · 134 moderate · 20 minor.

From our pharmacist’s overview on the Minocycline Hydrochloride page

“Minocycline (Ximino, Minolira), a tetracycline antibiotic often prescribed for acne and other infections, has a supplement record that deserves genuine care. Of the 161 ingredients on file, 7 carry a major rating, and those belong at the top of your reading.”

Reviewed by 2 · Jul 18, 2026

Open the Minocycline Hydrochloride interaction page

One more smart check

Taking Honey as Part of a Dietary Supplement Product? Check It for Interactions

We hold 298 real supplement products containing Honey, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Honey. Even though Honey itself has no known interaction with Minocycline Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Honey and Minocycline Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Honey

Top 25%

#268 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Minocycline Hydrochloride

Top half

#1,127 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Honey reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Honey and Minocycline Hydrochloride records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Honey

What is Honey?

Cough and sore throat
Wound and burn care
Soothing minor skin irritation
Sweetener and home remedy
Digestive upset

Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka honey is used. It is generally safe for most adults and children over 1 year, but should never be given to infants under 12 months because of the risk of botulism.

Honey produced by honeybees from flower nectar · Raw honey, processed honey, Manuka honey, medical-grade honey, lozenges, syrups, topical wound dressings

An interaction check asks whether these two react with each other — it does not ask whether Honey is a good idea for someone in your situation. Here is what our Honey record says about it on its own.

Honey: dosing

There is no official standardized dose for honey.

From our Honey monograph — the full record covers uses, side effects and every documented interaction.

Read the full Honey monograph & all interactions

Medication

About Minocycline

What Is Minocycline Used For?

Brand names: Ximino, Minolira

Oral and intravenous minocycline products treat many serious bacterial infections, including Rocky Mountain spotted fever, respiratory tract infections, sexually transmitted infections such as lymphogranuloma venereum and nongonococcal urethritis, plague, cholera, brucellosis, tularemia, and others caused by susceptible organisms. MINOCIN Intravenous is used when oral therapy is not adequate or tolerated.

Extended-release oral minocycline tablets are indicated specifically for inflammatory lesions of moderate to severe acne vulgaris in patients 12 years and older — not for treating infections. AMZEEQ (topical foam) treats inflammatory lesions of moderate to severe acne vulgaris in patients 9 years and older. ZILXI (topical foam) and EMROSI (oral capsule) are indicated for inflammatory lesions of rosacea in adults. ARESTIN (oral powder placed by a dental professional) is used alongside scaling and root planing to reduce pocket depth in adult periodontitis.

Most-Reported Side Effects for Minocycline Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (5,809 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug intolerance 969 reports

Rheumatoid arthritis 930 reports

Nausea 845 reports

Rash 821 reports

Arthralgia 811 reports

See full Minocycline drug information

Keep checking

Other Drugs & Honey

Browse every other medication we’ve checked against Honey — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

5Moderate

731Minor

2,093No known interaction

5 Moderate 731 Minor 2,093 No interaction

Moderate

5 interactions

Minor

731 interactions

Showing 60 of 731 minor interactions — see all 731 on the Honey page.

No interaction 2,093 drugs checked — show the list

We also checked Honey against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,093 medications checked with no known interaction — see the full Honey list.

See the full Honey interactions page

See every supplement checked against Minocycline Hydrochloride, ranked by severity

Evidence & sources

Honey References

The 40 references that drive our Honey monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
Bose B. Honey or sugar in treatment of infected wounds? Lancet 1982;1:963. PubMed
Ozhan H, Akdemir R, Yazici M, et al. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. PubMed
Centers for Disease Control. Botulism in the Unites Sates, 1899-1996. Handbook for epidemiologists, clinicians, and laboratory workers, 1998. Available online: http://www.cdc.gov/ncidod/dbmd/diseaseinfo/botulism.PDF.
Simon A, Traynor K, Santos K, et al. Medical honey for wound care - still the 'latest resort'? Evid Based Complement Alternat Med 2009;6:165-73. PubMed
Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Int Wound J 2005;2:10-15. PubMed
Ingle R, Levin J, Polinder K. Wound healing with honey - a randomised controlled trial. S Afr Med J 2006;96:831-5.
Johnson DW, van Eps C, Mudge DW, et al. Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. J Am Soc Nephrol 2005;16:1456-62. PubMed
Sukriti and Garg, S. K. Influence of honey on the pharmacokinetics of phenytoin in rabbits. Ind J Pharmacol 2002;34(147).
Jung, A. and Ottosson, J. [Infantile botulism caused by honey]. Ugeskr Laeger 2001;163(2):169.
Gunduz, A., Turedi, S., Uzun, H., and Topbas, M. Mad honey poisoning. Am J Emerg.Med 2006;24(5):595-598.
van der Vorst, M. M., Jamal, W., Rotimi, V. O., and Moosa, A. Infant botulism due to consumption of contaminated commercially prepared honey. First report from the Arabian Gulf States. Med Princ.Pract. 2006;15(6):456-458. PubMed
Tushar, T., Vinod, T., Rajan, S., Shashindran, C., and Adithan, C. Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. Basic Clin Pharmacol Toxicol 2007;100(4):269-272. PubMed
Nilforoushzadeh, M. A., Jaffary, F., Moradi, S., Derakhshan, R., and Haftbaradaran, E. Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis. BMC Complement Altern Med 2007;7:13. PubMed
Koca, I. and Koca, A. F. Poisoning by mad honey: a brief review. Food Chem Toxicol 2007;45(8):1315-1318. PubMed
Akinci, S., Arslan, U., Karakurt, K., and Cengel, A. An unusual presentation of mad honey poisoning: acute myocardial infarction. Int J Cardiol 2008;129(2):e56-e58. PubMed
Yildirim, N., Aydin, M., Cam, F., and Celik, O. Clinical presentation of non-ST-segment elevation myocardial infarction in the course of intoxication with mad honey. Am J Emerg Med 2008;26(1):108.e-2. PubMed
Shrestha, P., Vaidya, R., and Sherpa, K. Mad honey poisoning: a rare case report of seven cases. Nepal Med Coll J 2009;11(3):212-213.
Fetzner, L., Burhenne, J., Weiss, J., Völker, M., Unger, M., Mikus, G., and Haefeli, W. E. Daily honey consumption does not change CYP3A activity in humans. J Clin Pharmacol 2011;51(8):1223-1232. PubMed
Thamboo, A., Thamboo, A., Philpott, C., Javer, A., and Clark, A. Single-blind study of manuka honey in allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg 2011;40(3):238-243.
Ahmed, A., Khan, R. A., Azim, M. K., Saeed, S. A., Mesaik, M. A., Ahmed, S., and Imran, I. Effect of natural honey on human platelets and blood coagulation proteins. Pak.J Pharm Sci 2011;24(3):389-397.
Yarlioglues, M., Akpek, M., Ardic, I., Elcik, D., Sahin, O., and Kaya, M. G. Mad-honey sexual activity and acute inferior myocardial infarctions in a married couple. Tex.Heart Inst.J 2011;38(5):577-580.
Biberoglu, S., Biberoglu, K., and Komsuoglu, B. Mad honey. JAMA 4-1-1988;259(13):1943.
Biberoglu, K., Biberoglu, S., and Komsuoglu, B. Transient Wolff-Parkinson-White syndrome during honey intoxication. Isr.J.Med.Sci. 1988;24(4-5):253-254.
Gössinger, H., Hruby, K., Pohl, A., Davogg, S., Sutterlütti, G., and Mathis, G. [Poisoning with andromedotoxin-containing honey]. Dtsch Med Wochenschr 1983;108(41):1555-1558.
Fenicia, L., Ferrini, A. M., Aureli, P., and Pocecco, M. A case of infant botulism associated with honey feeding in Italy. Eur J Epidemiol 1993;9(6):671-673. PubMed
Sutlupinar, N., Mat, A., and Satganoglu, Y. Poisoning by toxic honey in Turkey. Arch.Toxicol. 1993;67(2):148-150. PubMed
von Malottki, K. and Wiechmann, H. W. [Acute life-threatening bradycardia: food poisoning by Turkish wild honey]. Dtsch.Med.Wochenschr. 7-26-1996;121(30):936-938.
Abdulla CO, Ayubi A, Zulfiquer F, Santhanam G, Ahmed MA, Deeb J. Infant botulism following honey ingestion. BMJ Case Rep. 2012 Sep 7;2012.
Johnson DW, Badve SV, Pascoe EM, Beller E, Cass A, Clark C, de Zoysa J, Isbel NM, McTaggart S, Morrish AT, Playford EG, Scaria A, Snelling P, Vergara LA, Hawley CM; HONEYPOT Study Collaborative Group. Antibacterial honey for the prevention of peritoneal-d
Matos D, Serrano P, Menezes Brandão F. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis. 2015 Jan;72(1):59-60. PubMed
Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014 Dec 23;12:CD007094. PubMed
Vezir E, Kaya A, Toyran M, Azkur D, Dibek Misirlioglu E, Kocabas CN. Anaphylaxis/angioedema caused by honey ingestion. Allergy Asthma Proc. 2014 Jan-Feb;35(1):71-4. PubMed
Wang YT, Qi Y, Tang FY, et al. The effect of cupping therapy for low back pain: A meta-analysis based on existing randomized controlled trials. J Back Musculoskelet Rehabil. 2017;30(6):1187-1195. PubMed
Oduwole O, Udoh EE, Oyo-Ita A, Meremikwu MM. Honey for acute cough in children. Cochrane Database Syst Rev. 2018;4:CD007094. PubMed
Wong D, Albietz JM, Tran H, et al. Treatment of contact lens related dry eye with antibacterial honey. Cont Lens Anterior Eye. 2017;40(6):389-393. PubMed
Martina SJ, Ramar LAP, Silaban MRI, Luthfi M, Govindan PAP. Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice. Open Access Maced J Med Sci. 2019 Oct 14;7(20):3416-3420. PubMed
Jhawar N, Gonzalez-Estrada A. Honey-induced anaphylaxis in an adult. QJM 2022;115(5):325-326. PubMed
Di Costanzo M, De Paulis N, Peveri S, Montagni M, Berni Canani R, Biasucci G. Anaphylaxis caused by artisanal honey in a child: a case report. J Med Case Rep 2021;15(1):235. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Minocycline Hydrochloride Is Linked to Lower Levels of 11 Nutrients

Natural Medicines records Minocycline Hydrochloride as a medicine that can lower these. This is not an interaction with Honey — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

Read the full Minocycline Hydrochloride nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking Honey and Minocycline Hydrochloride Together: Common Questions

Is it safe to take Honey with Minocycline Hydrochloride?

We do not list a known interaction between Honey and Minocycline Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Honey and Minocycline Hydrochloride have any of the same side effects?

Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Honey and Minocycline Hydrochloride used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Honey in each. That is a conversation for your prescriber, especially if Minocycline Hydrochloride is being adjusted to a target.

How was the Honey and Minocycline Hydrochloride combination checked?

Interactions in our licensed database are recorded against drug classes. Minocycline Hydrochloride is filed under 7 classifications, and Honey has documented interactions with 3 drug classes — none of Minocycline Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Honey interact with any other medications?

Yes. Honey has 736 documented drug interactions in our database — Minocycline Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Minocycline Hydrochloride interact with any supplements?

Yes. Minocycline Hydrochloride has documented interactions with 161 supplements in our database — Honey is not one of them. The Minocycline Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Honey monograph Uses, safety profile, and every drug interaction in one place Minocycline drug information The full plain-English guide to this medication Minocycline Hydrochloride supplement interactions Every supplement checked against Minocycline Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 40 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Minocycline Hydrochloride and Honey?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.