Drug & supplement interaction

Honeysuckle + Dicumarol

Dicumarol brand name: Dicumarol.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Honeysuckle has a moderate interaction with Dicumarol. Theoretically, honeysuckle might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Honeysuckle and Dicumarol

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Dicumarol

Dicumarol falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Honeysuckle interacts with.

Theoretically, honeysuckle might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that polyphenols extracted from honeysuckle can inhibit platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Dicumarol is a blood thinner, similar in spirit to warfarin, so it already lowers your blood's ability to clot. The concern here is simple: honeysuckle may add a little extra blood-thinning push on top of what Dicumarol is already doing. In lab studies, certain plant compounds in honeysuckle slowed platelets from clumping together. Stacked with Dicumarol, that could nudge your bleeding risk a bit higher, showing up as easy bruising, nosebleeds, bleeding gums, or cuts that take longer to stop.

I want to be honest about the evidence though: this is based only on test-tube research, not real patients, so it's theoretical. A cup of honeysuckle tea now and then is unlikely to be a problem, but before adding concentrated supplements, please check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chang WC, Hsu FL. Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb. Prostaglandins Leukot Essent Fatty Acids 1992;45:307-12. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Honeysuckle Also Interacts With Other Medications

Honeysuckle has 121 moderate known drug interactions in our database — the Dicumarol one above is one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Dicumarol)
Taking anything else?

Check Another of Your Medications Against Honeysuckle

Covers the 2,830 medications we’ve checked against Honeysuckle. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Dicumarol

This page covers Honeysuckle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dicumarol page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 190 moderate · 25 minor.

From our pharmacist’s overview on the Dicumarol page

“Danshen tops my worry list for anyone taking dicumarol, an older blood thinner in the warfarin family. It has clot-blocking activity of its own, and stacking it on an anticoagulant can push bleeding risk too far.”

Reviewed by 2 · Jul 18, 2026

Open the Dicumarol interaction page

One more smart check

Taking Honeysuckle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 41 real supplement products containing Honeysuckle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Honeysuckle. Your product may carry other ingredients that interact with Dicumarol too, on top of Honeysuckle — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Honeysuckle and Dicumarol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Honeysuckle
Top half

#449 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dicumarol
Steady interest

#2,155 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Honeysuckle

What is Honeysuckle?

  • Colds and sore throat
  • Fever
  • Inflammation
  • Skin rashes and sores
  • Digestive upset

Honeysuckle, especially Japanese honeysuckle flower (Lonicera japonica), is a staple of traditional Chinese medicine used mainly for colds, sore throat, and inflammation. Modern human evidence for these uses is limited, so it should be seen as a traditional remedy rather than a proven treatment. It is generally well tolerated as a tea, but talk to your pharmacist or doctor before using it, especially if you are pregnant, nursing, or taking other medicines.

Read the full Honeysuckle monograph & all interactions
Keep checking

Other Drugs & Honeysuckle

Browse every other medication we’ve checked against Honeysuckle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Honeysuckle page.

No interaction 2,708 drugs checked — show the list

We also checked Honeysuckle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Honeysuckle list.

See the full Honeysuckle interactions page
See every supplement checked against Dicumarol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Honeysuckle monograph › Uses, safety, and every drug interaction in one place Dicumarol supplement interactions › Every supplement checked against Dicumarol, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Honeysuckle and Dicumarol Together: Common Questions

Can you take Honeysuckle with Dicumarol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Honeysuckle and Dicumarol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dicumarol and Honeysuckle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.