Drug & supplement interaction

Horseradish + Cefuroxime

Cefuroxime brand names: Ceftin, Kefurox, Zinacef.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Horseradish and Cefuroxime in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Horseradish and Cefuroxime

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cefuroxime and Horseradish in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Horseradish safety at a glance

Horseradish overall Use caution Food amounts are generally safe, but concentrated supplements may irritate the digestive tract and mucous membranes.
Pregnancy Avoid Avoid medicinal amounts during pregnancy because safety has not been established.
Breastfeeding Likely Safe When the root is used orally in amounts commonly found in foods. Horseradish has Generally Recognized as Safe (GRAS) status in the US. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cefuroxime and Horseradish? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cefuroxime

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cefuroxime is filed under 6 classifications — including organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates, antibiotic drugs. Horseradish has documented interactions with 1 drug class — the most serious being thyroid hormone (moderate) — and none of Cefuroxime’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Horseradish Does Interact With Other Medications

Horseradish has 16 moderate known drug interactions in our database — Cefuroxime isn’t one of them. If you take anything else, check it against the full list below.

Moderate 16 No known interaction 2,814 (incl. Cefuroxime)
Taking anything else?

Check Another of Your Medications Against Horseradish

Covers the 2,830 medications we’ve checked against Horseradish. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Horseradish and Cefuroxime May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Horseradish

    “Orally, horseradish is generally well tolerated when consumed in amounts commonly used with foods. But consuming large amounts of horseradish can cause various adverse effects.

    Most Common Adverse Effects:

    Orally: When consumed in large amounts, bloody vomiting, diarrhea, gastrointestinal upset.

    Topically: Fresh horseradish can cause irritation or allergic reaction.

    Serious Adverse Effects (Rare):

    Orally: Transient v…”

    Horseradish · Natural Medicines adverse-effect record, reported in diarrhea.

    Cefuroxime

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefuroxime. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Horseradish

    “Orally, consuming large amounts of horseradish can cause vasovagal syncope in rare cases. At least two cases of vasovagal syncope associated with horseradish consumption have been reported. In one case, a 56-year-old male experienced a sharp burning sensation in his stomach followed by tachycardia, weakness, and excessive perspiration after consuming an oyster topped with an olive-sized dollop of fresh horseradish.”

    Horseradish · Natural Medicines adverse-effect record, reported in irregular heartbeat.

    1 source cited
    1. 111724. Lehmann CU, Puckett AL, Betz BO. 56-year-old man - increased heart rate - weakness - intense sweating - horseradish consumption - Dx?. J Fam Pract 2022;71(7):317-321. PubMed

    Cefuroxime

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefuroxime. Read the label on DailyMed ›

  • Stomach upset / Diarrhea / Vomiting reported in 6.0% of FDA reports for Cefuroxime Additional detail

    Horseradish

    “Orally, consuming large amounts of horseradish can cause gastrointestinal upset, bloody vomiting and diarrhea (2,6), and irritation of mucous membranes (2,4).”

    Horseradish · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    3. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    Cefuroxime

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefuroxime, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Horseradish but not commonly for Cefuroxime: sweating and fainting.

Effects for Cefuroxime come from the ADVERSE REACTIONS section of its FDA label; effects for Horseradish come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 15,671 voluntary FDA FAERS reports for Cefuroxime that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Horseradish in Pregnancy & Breastfeeding

Lactation Likely Safe

When the root is used orally in amounts commonly found in foods. Horseradish has Generally Recognized as Safe (GRAS) status in the US.

Lactation Likely Unsafe

When used orally in large amounts. The mustard oils produced by glucosinolates from horseradish are considered toxins that can be excreted through breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Cefuroxime Is Prescribed For, and What Horseradish Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Cefuroxime is a prescription medicine with approved uses on its FDA label. Horseradish is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Cefuroxime is prescribed for: Cefuroxime Axetil tablets treat several common bacterial infections in adults and children, including strep throat, ear infections (in children who can swallow tablets), sinus infections, acute flare-ups of chronic bronchitis, uncomplicated skin infections, urinary tract infections, uncomplicated gonorrhea, and early Lyme disease. The injectable forms — Cefuroxime and Cefuroxime sodium — are used in hospital or clinical settings to treat more serious infections, including pneumonia and other lower respiratory tract infections, urinary tract infections, skin and skin-structure infections, septicemia (blood infection), meningitis (infection of the brain and spinal cord lining), gonorrhea, and bone and joint infections. The injectable forms are also used to help prevent infections in certain surgical procedures.

Horseradish has been studied for:

  • Respiratory tract infections studied, not established Horseradish has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Horseradish for respiratory tract infections

    Oral horseradish root has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Cefuroxime on your own; if you are taking Horseradish for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Horseradish or Cefuroxime

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Horseradish or Cefuroxime, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Cefuroxime

This page covers Horseradish only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefuroxime page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefuroxime page

“Cefuroxime (Ceftin, Zinacef) treats everyday infections like sinusitis and bronchitis, and three of its 60 listed supplement interactions rate major, enough that this page deserves unhurried attention. Two of those majors, Siberian cocklebur and asarabacca, can injure the kidneys on their own, an added burden for a drug your kidneys mu…”

Reviewed by 2 · Jul 18, 2026

Open the Cefuroxime interaction page

One more smart check

Taking Horseradish as Part of a Dietary Supplement Product? Check It for Interactions

We hold 245 real supplement products containing Horseradish, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Horseradish. Even though Horseradish itself has no known interaction with Cefuroxime, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Horseradish and Cefuroxime Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Horseradish
Top half

#392 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefuroxime
Top half

#776 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Horseradish reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Horseradish and Cefuroxime records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Horseradish

What is Horseradish?

  • Sinus and respiratory congestion
  • Urinary tract infections
  • Digestive support
  • Antimicrobial
  • Culinary flavoring

Horseradish is a pungent root used as a food and folk remedy, most often for sinus congestion and urinary tract complaints. Human evidence is limited, and while culinary amounts are generally well tolerated, concentrated supplements can irritate the stomach and should be used cautiously. Talk with your pharmacist or doctor before using horseradish as a medicine.

Armoracia rusticana · Brassicaceae · Root (fresh or dried) · Fresh grated root, dried root powder, prepared condiment (sauce), capsules, tinctures

An interaction check asks whether these two react with each other — it does not ask whether Horseradish is a good idea for someone in your situation. Here is what our Horseradish record says about it on its own.

Horseradish: dosing

There is no well-established standardized medicinal dose for horseradish. Amounts used in research and traditional practice vary widely depending on the form (fresh root, dried powder, or extract).If you use a commercial supplement, follow the directions on the product label and do not exceed the recommended amount. Avoid taking large or concentrated amounts in hopes of stronger effects, since this mainly increases the risk of irritation and side effects.

From our Horseradish monograph — the full record covers uses, side effects and every documented interaction.

Read the full Horseradish monograph & all interactions
Medication

About Cefuroxime

What Is Cefuroxime Used For?

Brand names: Ceftin, Kefurox, Zinacef

Cefuroxime Axetil tablets treat several common bacterial infections in adults and children, including strep throat, ear infections (in children who can swallow tablets), sinus infections, acute flare-ups of chronic bronchitis, uncomplicated skin infections, urinary tract infections, uncomplicated gonorrhea, and early Lyme disease.

The injectable forms — Cefuroxime and Cefuroxime sodium — are used in hospital or clinical settings to treat more serious infections, including pneumonia and other lower respiratory tract infections, urinary tract infections, skin and skin-structure infections, septicemia (blood infection), meningitis (infection of the brain and spinal cord lining), gonorrhea, and bone and joint infections. The injectable forms are also used to help prevent infections in certain surgical procedures.

Most-Reported Side Effects for Cefuroxime

From FAERS, the FDA’s public side-effect reporting system (15,671 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 1,030 reports
Diarrhea 943 reports
Pneumonia 843 reports
Fever 795 reports
Fatigue 782 reports
See full Cefuroxime drug information
Keep checking

Other Drugs & Horseradish

Browse every other medication we’ve checked against Horseradish — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
16Moderate
0Minor
2,813No known interaction
16 Moderate 2,813 No interaction
Moderate

16 interactions

No interaction 2,813 drugs checked — show the list

We also checked Horseradish against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,813 medications checked with no known interaction — see the full Horseradish list.

See the full Horseradish interactions page
See every supplement checked against Cefuroxime, ranked by severity
Evidence & sources

Horseradish References

The 6 references that drive our Horseradish monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  5. Panter, K. E. and James, L. F. Natural plant toxicants in milk: a review. J Anim Sci 1990;68(3):892-904. PubMed
  6. Lehmann CU, Puckett AL, Betz BO. 56-year-old man - increased heart rate - weakness - intense sweating - horseradish consumption - Dx?. J Fam Pract 2022;71(7):317-321. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Horseradish and Cefuroxime Together: Common Questions

Is it safe to take Horseradish with Cefuroxime?
We do not list a known interaction between Horseradish and Cefuroxime. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Horseradish and Cefuroxime have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Horseradish and Cefuroxime used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Horseradish in each. That is a conversation for your prescriber, especially if Cefuroxime is being adjusted to a target.
How was the Horseradish and Cefuroxime combination checked?
Interactions in our licensed database are recorded against drug classes. Cefuroxime is filed under 6 classifications, and Horseradish has documented interactions with 1 drug class — none of Cefuroxime's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Horseradish interact with any other medications?
Yes. Horseradish has 16 documented drug interactions in our database — Cefuroxime is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cefuroxime interact with any supplements?
Yes. Cefuroxime has documented interactions with 60 supplements in our database — Horseradish is not one of them. The Cefuroxime interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Horseradish monograph Uses, safety profile, and every drug interaction in one place Cefuroxime drug information The full plain-English guide to this medication Cefuroxime supplement interactions Every supplement checked against Cefuroxime, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cefuroxime and Horseradish?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.