Drug & supplement interaction

Houseleek + Itraconazole

Itraconazole brand names: Sporanox, Sporanox Injection, Tolsura.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Houseleek and Itraconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Houseleek and Itraconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Itraconazole and Houseleek in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Houseleek at all — not against Itraconazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Houseleek safety at a glance

Houseleek overall Use caution It has a long history of topical folk use, but modern safety data is limited, especially for taking it by mouth.
Pregnancy Avoid There is not enough reliable safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Itraconazole and Houseleek? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Itraconazole’s Own FDA Label Lists

This is not an interaction — none of it involves Houseleek. These are the most notable effects listed in the ADVERSE REACTIONS section of Itraconazole’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Low magnesium Worth acting on
  • Hearing loss Worth acting on
  • Severe muscle breakdown Worth acting on
  • Dehydration Worth acting on
  • Trouble swallowing Worth acting on
  • High potassium Worth acting on
  • Low potassium Worth acting on
  • A slow heartbeat Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on

Showing the 10 most notable of 64 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Itraconazole. Read the label on DailyMed › Where a percentage is shown, it is the share of 11,613 voluntary FDA FAERS reports for Itraconazole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Houseleek’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Houseleek side to compare — that is a limit of the record, not a statement that Houseleek has no side effects.

From our Q&A

Questions About Houseleek or Itraconazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Houseleek or Itraconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Itraconazole

This page covers Houseleek only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Itraconazole page lists 182 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 136 moderate · 40 minor.

From our pharmacist’s overview on the Itraconazole page

“Serious fungal infections are what itraconazole (Sporanox, Tolsura) is for, and the drug travels through CYP3A4, the liver enzyme that also handles a large share of supplements. That overlap is why this list reaches 182 ingredients, and it earns genuine care; start with the six rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Itraconazole interaction page

How much people look this up

Where Houseleek and Itraconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Houseleek
Steady interest

#1,102 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Itraconazole
Top half

#1,391 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Houseleek is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Houseleek reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Houseleek and Itraconazole records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Houseleek

What is Houseleek?

  • Minor burns and skin irritation
  • Insect bites and stings
  • Warts and corns
  • Earache (traditional folk use)
  • Soothing cuts and scrapes

Houseleek is a hardy succulent traditionally applied to the skin for minor burns, bites, and irritations, much like aloe vera. Scientific evidence supporting its benefits is very limited and mostly comes from traditional use and laboratory studies, so it should not replace proven treatments. Talk to a pharmacist or doctor before using it, especially during pregnancy or breastfeeding.

Sempervivum tectorum · Crassulaceae · Leaves and the juice (sap) pressed from the leaves · Fresh leaf juice or pulp, poultices, ointments, and occasionally infusions

An interaction check asks whether these two react with each other — it does not ask whether Houseleek is a good idea for someone in your situation. Here is what our Houseleek record says about it on its own.

Houseleek: dosing

There is no standardized or well-established dose for houseleek. Traditional use involved applying the fresh leaf juice or crushed leaf pulp directly to the skin as needed, but no proven, measured dosing exists.If you choose to use a commercial product such as an ointment or gel, follow the directions on the label.

From our Houseleek monograph — the full record covers uses, side effects and every documented interaction.

Read the full Houseleek monograph & all interactions
Medication

About Itraconazole

What Is Itraconazole Used For?

Brand names: Sporanox, Sporanox Injection, Tolsura

Itraconazole capsules (including Sporanox capsules and generic itraconazole capsules) treat serious fungal infections — blastomycosis, histoplasmosis, and aspergillosis — in both people with normal immune systems and those who are immunocompromised. Capsule forms are also approved for nail fungus (onychomycosis) caused by dermatophytes in non-immunocompromised patients. Tolsura (a gelatin-coated capsule formulation) treats blastomycosis, histoplasmosis, and aspergillosis in adults, but is not approved for nail fungus and is not interchangeable with other itraconazole products.

Itraconazole oral solution is specifically approved for oropharyngeal candidiasis (thrush — a fungal infection of the mouth) and esophageal candidiasis (a fungal infection of the food pipe). Only the oral solution has been shown to work for these mouth and throat infections; capsules cannot be substituted for this use.

Most-Reported Side Effects for Itraconazole

From FAERS, the FDA’s public side-effect reporting system (11,613 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 590 reports
Dyspnea 489 reports
Pneumonia 484 reports
Nausea 459 reports
Diarrhea 398 reports
See full Itraconazole drug information
Keep checking

Other Drugs & Houseleek

Browse every other medication we’ve checked against Houseleek — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Houseleek against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Houseleek list.

See the full Houseleek interactions page
See every supplement checked against Itraconazole, ranked by severity
Evidence & sources

Houseleek References

The 1 sources that drive our Houseleek monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Houseleek is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Houseleek and Itraconazole Together: Common Questions

Is it safe to take Houseleek with Itraconazole?
We do not list a known interaction between Houseleek and Itraconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Itraconazole interact with any supplements?
Yes. Itraconazole has documented interactions with 182 supplements in our database — Houseleek is not one of them. The Itraconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Houseleek monograph Uses, safety profile, and every drug interaction in one place Itraconazole drug information The full plain-English guide to this medication Itraconazole supplement interactions Every supplement checked against Itraconazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Itraconazole and Houseleek?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.