Drug & supplement interaction

Immunoaugmentative Therapy + Leflunomide

Leflunomide brand name: Arava.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Immunoaugmentative Therapy and Leflunomide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Immunoaugmentative Therapy and Leflunomide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Leflunomide and Immunoaugmentative Therapy in our sources. This does not guarantee that the combination is completely free of risk — research on Immunoaugmentative Therapy alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Immunoaugmentative Therapy at all — not against Leflunomide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Immunoaugmentative Therapy is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Immunoaugmentative Therapy safety at a glance

Immunoaugmentative... overall Avoid IAT is unproven, not standardized, and carries infection and other risks; it is not recommended.
Pregnancy Avoid There is no safety data; avoid this unproven injectable therapy during pregnancy.
Breastfeeding Avoid No safety information exists; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Leflunomide and Immunoaugmentative Therapy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Immunoaugmentative Therapy and Leflunomide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so having Immunoaugmentative Therapy while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Immunoaugmentative Therapy

    “Subcutaneously, serious infections, such as HIV and hepatitis B, have been reported after receiving immunoaugmentative therapy. This has raised the concern that the products used in therapy may be derived from infected individuals, without undergoing adequate sterilization processes.”

    Immunoaugmentative Therapy · Natural Medicines adverse-effect record, reported in hepatitis.

    2 sources cited
    1. 102928. Green S. Immunoaugmentative therapy. An unproven cancer treatment. JAMA 199313;270(14):1719-23. DOI
    2. 102929. Questionable Methods of Cancer Management: Immuno-augmentative Therapy (IAT). CA Cancer Journal for Clinicians1991;41(6):357-64.

    Leflunomide

    Listed in the ADVERSE REACTIONS section of the FDA label for Leflunomide. Read the label on DailyMed ›

  • A higher chance of infection Worth acting on Additional detail

    Immunoaugmentative Therapy

    “Immunoaugmentative therapy has never been thoroughly evaluated in clinical research. Case reports suggest that subcutaneous immunoaugmentative therapy can cause fatigue, flu-like illness, pain at the injection site, generalized pain, and swelling.”

    Immunoaugmentative Therapy · Natural Medicines adverse-effect record, reported in fatigue.

    3 sources cited
    1. 102927. Pfeifer BL, Jonas WB. Clinical evaluation of "immunoaugmentative therapy (IAT)": an unconventional cancer treatment. Integr Cancer Ther. 2003;2(2):112-9. PubMed
    2. 102928. Green S. Immunoaugmentative therapy. An unproven cancer treatment. JAMA 199313;270(14):1719-23. DOI
    3. 102929. Questionable Methods of Cancer Management: Immuno-augmentative Therapy (IAT). CA Cancer Journal for Clinicians1991;41(6):357-64.

    Leflunomide

    Listed in the ADVERSE REACTIONS section of the FDA label for Leflunomide. Read the label on DailyMed ›

  • Tiredness reported in 15.1% of FDA reports for Leflunomide Additional detail

    Immunoaugmentative Therapy

    “Subcutaneously, fatigue has been reported after immunoaugmentative therapy.”

    Immunoaugmentative Therapy · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 102927. Pfeifer BL, Jonas WB. Clinical evaluation of "immunoaugmentative therapy (IAT)": an unconventional cancer treatment. Integr Cancer Ther. 2003;2(2):112-9. PubMed

    Leflunomide

    Listed in the ADVERSE REACTIONS section of the FDA label for Leflunomide, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Immunoaugmentative Therapy but not commonly for Leflunomide: swelling.

Effects for Leflunomide come from the ADVERSE REACTIONS section of its FDA label; effects for Immunoaugmentative Therapy come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 104,033 voluntary FDA FAERS reports for Leflunomide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Leflunomide

This page covers Immunoaugmentative Therapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Leflunomide page lists 59 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 46 moderate · 9 minor.

From our pharmacist’s overview on the Leflunomide page

“Leflunomide (Arava) quiets rheumatoid arthritis by damping down the immune system, and its best-known danger is liver injury, so the 59 supplements and herbs on this page are worth slowing down for. Thirty-eight of them carry liver risks of their own, and of the four rated major, two are simply alcoholic drinks, while a third, Siberian…”

Reviewed by 2 · Jul 18, 2026

Open the Leflunomide interaction page

How much people look this up

Where Immunoaugmentative Therapy and Leflunomide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Immunoaugmentative Therapy
Steady interest

#931 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Leflunomide
Steady interest

#2,319 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Immunoaugmentative Therapy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Immunoaugmentative Therapy and Leflunomide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Immunoaugmentative Therapy

What is Immunoaugmentative Therapy?

  • Cancer (as an alternative therapy)
  • Attempts to boost the immune system
  • Tumor reduction claims

Immunoaugmentative Therapy (IAT) is an unproven alternative cancer treatment, not a dietary supplement or herb. It involves injecting blood-derived protein mixtures, but there is no reliable scientific evidence that it treats cancer or any other disease, and it carries real safety risks. Talk to your oncologist before considering any alternative cancer therapy.

Not applicable (this is a treatment procedure, not a plant or herb) · Injections of blood-derived protein fractions given at a treatment clinic

An interaction check asks whether these two react with each other — it does not ask whether Immunoaugmentative Therapy is a good idea for someone in your situation. Here is what our Immunoaugmentative Therapy record says about it on its own.

Immunoaugmentative Therapy: dosing

There is no established or standardized dose for Immunoaugmentative Therapy, and it is not a product you can buy as a supplement. It was administered only at specific clinics following protocols that were never validated by mainstream science.HelloPharmacist does not recommend IAT.

From our Immunoaugmentative Therapy monograph — the full record covers uses, side effects and every documented interaction.

Read the full Immunoaugmentative Therapy monograph & all interactions
Medication

About Leflunomide

What Is Leflunomide Used For?

Brand name: Arava

Leflunomide tablets — sold under the brand name Arava and as generic leflunomide — are used to treat active rheumatoid arthritis (RA) in adults. Both Arava and generic leflunomide tablets are FDA-approved for this use.

Rheumatoid arthritis is an autoimmune condition in which the immune system attacks the joints, causing pain, swelling, and stiffness. Leflunomide helps calm that overactive immune response to reduce symptoms and slow joint damage.

Most-Reported Side Effects for Leflunomide

From FAERS, the FDA’s public side-effect reporting system (104,033 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Rheumatoid arthritis 25,337 reports
Arthralgia 17,395 reports
Drug intolerance 15,935 reports
Joint swelling 15,925 reports
Fatigue 15,756 reports
See full Leflunomide drug information
Keep checking

Other Drugs & Immunoaugmentative Therapy

Browse every other medication we’ve checked against Immunoaugmentative Therapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Immunoaugmentative Therapy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Immunoaugmentative Therapy list.

See the full Immunoaugmentative Therapy interactions page
See every supplement checked against Leflunomide, ranked by severity
Evidence & sources

Immunoaugmentative Therapy References

The 3 references that drive our Immunoaugmentative Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pfeifer BL, Jonas WB. Clinical evaluation of "immunoaugmentative therapy (IAT)": an unconventional cancer treatment. Integr Cancer Ther. 2003;2(2):112-9. PubMed
  2. Green S. Immunoaugmentative therapy. An unproven cancer treatment. JAMA 199313;270(14):1719-23. DOI
  3. Questionable Methods of Cancer Management: Immuno-augmentative Therapy (IAT). CA Cancer Journal for Clinicians1991;41(6):357-64.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Immunoaugmentative Therapy While Taking Leflunomide: Common Questions

Is it safe to have Immunoaugmentative Therapy while taking Leflunomide?
We do not list a known interaction between Immunoaugmentative Therapy and Leflunomide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Immunoaugmentative Therapy and Leflunomide have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Leflunomide interact with any supplements?
Yes. Leflunomide has documented interactions with 59 supplements in our database — Immunoaugmentative Therapy is not one of them. The Leflunomide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Immunoaugmentative Therapy monograph Uses, safety profile, and every drug interaction in one place Leflunomide drug information The full plain-English guide to this medication Leflunomide supplement interactions Every supplement checked against Leflunomide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Leflunomide and Immunoaugmentative Therapy?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.