Inosine + Granisetron
Granisetron brand names: Kytril, Sustol.
We found no known interaction between Inosine and Granisetron in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Granisetron states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Inosine and Granisetron
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Granisetron and Inosine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Inosine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Granisetron
Interactions in our licensed database are recorded against drug classes, not just single drug names. Granisetron is filed under 3 classifications — serotonergic drugs, serotonergic drugs, oral drugs. Inosine has documented interactions with 1 drug class — the most serious being antigout drugs (moderate) — and none of Granisetron’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Inosine Does Interact With Other Medications
Inosine has 9 moderate known drug interactions in our database — Granisetron isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Inosine
We haven’t checked that one against Inosine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Inosine. Pick one to open its full report.
Some Granisetron Products Have a Food Rule — Inosine Should Not Break It
At least one FDA label for a product containing Granisetron says to take it on an empty stomach. Most supplements — Inosine included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Granisetron on its own and move Inosine to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Granisetron products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Recommended Dosage ( 2.2 ): The recommended dosage in adults is 10 mg administered as a single subcutaneous injection at least 30 minutes before the start of emetogenic chemotherapy on Day 1.
From the Dosage and Administration section of the FDA label we read for Granisetron — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Granisetron Is Prescribed For, and What Inosine Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Granisetron is a prescription medicine with approved uses on its FDA label. Inosine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Granisetron is prescribed for: Granisetron is used to prevent nausea and vomiting linked to emetogenic (nausea-causing) cancer chemotherapy — including high-dose cisplatin — and radiation therapy, including total body irradiation and fractionated abdominal radiation. Granisetron hydrochloride tablets and Granisol oral solution are approved for both the chemotherapy and radiation indications. Sancuso skin patch is approved for prevention of nausea and vomiting in adults receiving moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days. Granisetron hydrochloride injection (intravenous) is also used to prevent and treat postoperative nausea and vomiting in adults.
Read the rest of what Granisetron is prescribed for
Sustol (subcutaneous injection) is used in combination with other anti-nausea medicines in adults specifically for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy or anthracycline and cyclophosphamide combination chemotherapy regimens.
Inosine has been studied for:
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Cancer studied, not established Inosine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Inosine for cancer
It is unclear if oral inosine is beneficial for cancer.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Granisetron on your own; if you are taking Inosine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Granisetron
This page covers Inosine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Granisetron page lists 38 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Ayahuasca (moderate).
By severity: 2 major · 25 moderate · 11 minor.
From our pharmacist’s overview on the Granisetron page
“Granisetron (Kytril, Sustol) blocks serotonin signals to stop nausea from chemotherapy and surgery, and this is a list that warrants real caution before you add a supplement to it. Most of the entries raise serotonin themselves, and stacking them on a serotonin-acting drug can push toward serotonin syndrome, a dangerous overload of tha…”
Reviewed by 2 · Jul 18, 2026
Taking Inosine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 93 real supplement products containing Inosine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Inosine. Even though Inosine itself has no known interaction with Granisetron, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Inosine and Granisetron Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#896 of 1,452 supplements looked up here in the last 7 days
#2,102 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Inosine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Inosine and Granisetron records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Inosine
What is Inosine?
- Athletic performance and energy
- Multiple sclerosis (raising uric acid)
- Parkinson's disease (raising uric acid)
- General health and recovery
Inosine is a nucleoside (a building block of DNA and RNA) that the body makes on its own and is also sold as a supplement, mostly marketed for athletic performance. Solid evidence that it boosts exercise performance is lacking, and because it raises uric acid levels, it may pose risks for people with gout or kidney problems. Talk with your pharmacist or doctor before using it.
Not applicable; inosine is a naturally occurring compound (a nucleoside), not a plant part · Capsules, tablets, powder
An interaction check asks whether these two react with each other — it does not ask whether Inosine is a good idea for someone in your situation. Here is what our Inosine record says about it on its own.
Inosine: dosing
There is no well-established, standardized dose of inosine. Amounts used in studies have varied, and there is no proven safe or effective dose for general use.If you choose to use an inosine product, follow the directions on the label and do not exceed the recommended amount. Do not assume that taking more will give better results.
From our Inosine monograph — the full record covers uses, side effects and every documented interaction.
About Granisetron
What Is Granisetron Used For?
Brand names: Kytril, Sustol
Granisetron is used to prevent nausea and vomiting linked to emetogenic (nausea-causing) cancer chemotherapy — including high-dose cisplatin — and radiation therapy, including total body irradiation and fractionated abdominal radiation. Granisetron hydrochloride tablets and Granisol oral solution are approved for both the chemotherapy and radiation indications. Sancuso skin patch is approved for prevention of nausea and vomiting in adults receiving moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days.
Granisetron hydrochloride injection (intravenous) is also used to prevent and treat postoperative nausea and vomiting in adults. Sustol (subcutaneous injection) is used in combination with other anti-nausea medicines in adults specifically for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy or anthracycline and cyclophosphamide combination chemotherapy regimens.
Other Drugs & Inosine
Browse every other medication we’ve checked against Inosine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
9 interactions
No interaction 2,820 drugs checked — show the list
We also checked Inosine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,820 medications checked with no known interaction — see the full Inosine list.
Inosine References
The 7 references that drive our Inosine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Parkinson Study Group SURE-PD Investigators. Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol. 2014;71(2):141-50.
- Muñoz García D, Midaglia L, Martinez Vilela J, et al. Associated inosine to interferon: results of a clinical trial in multiple sclerosis. Acta Neurol Scand. 2015;131(6):405-10. PubMed
- Gonsette RE, Sindic C, D'hooghe MB, et al. Boosting endogenous neuroprotection in multiple sclerosis: The association of inosine and interferon beta in relapsing-remitting Multiple Sclerosis (ASIIMS) trial. Mult Scler. 2010;16(4):455-62.
- Markowitz CE, Spitsin S, Zimmerman V, et al. The treatment of multiple sclerosis with inosine. J Altern Complement Med. 2009;15(6):619-25. PubMed
- Watanabe H, Hattori T, Kume A, et al. Improved Parkinsons disease motor score in a single-arm open-label trial of febuxostat and inosine. Medicine (Baltimore) 2020;99(35):e21576. PubMed
- Parkinson Study Group SURE-PD3 Investigators, Schwarzschild MA, Ascherio A, et al. Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial. JAMA 2021;326(10):926-939.
- Walk D, Nicholson K, Locatelli E, et al. Randomized trial of inosine for urate elevation in amyotrophic lateral sclerosis. Muscle Nerve 2023;67(5):378-386. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Inosine and Granisetron Together: Common Questions
Is it safe to take Inosine with Granisetron?
Do Inosine and Granisetron have any of the same side effects?
Should I take Inosine and Granisetron at the same time of day?
Are Inosine and Granisetron used for the same thing?
How was the Inosine and Granisetron combination checked?
Does Inosine interact with any other medications?
Does Granisetron interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.