Drug & supplement interaction

Lactobacillus Delbrueckii + Brigatinib

Brigatinib brand name: Alunbrig.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Lactobacillus Delbrueckii and Brigatinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Lactobacillus Delbrueckii and Brigatinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Brigatinib and Lactobacillus Delbrueckii in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lactobacillus Delbrueckii safety at a glance

Lactobacillus Delb... overall Use caution Generally well tolerated in healthy people, but people who are very ill or immunocompromised should be cautious.
Pregnancy Use caution Probiotics in food are likely fine, but supplement safety in pregnancy is not well studied, so check with your doctor.
Breastfeeding Use caution Limited specific data, so use only with guidance from your healthcare provider.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Brigatinib and Lactobacillus Delbrueckii? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Brigatinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Brigatinib is filed under 3 classifications — cytochrome p450 3a4 (cyp3a4) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Lactobacillus Delbrueckii has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Brigatinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lactobacillus Delbrueckii Does Interact With Other Medications

Lactobacillus Delbrueckii has 182 moderate known drug interactions in our database — Brigatinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Brigatinib)
Taking anything else?

Check Another of Your Medications Against Lactobacillus Delbrueckii

Covers the 2,830 medications we’ve checked against Lactobacillus Delbrueckii. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Lactobacillus Delbrueckii and Brigatinib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Lactobacillus Delbrueckii

    “Since Lactobacillus delbrueckii preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. Some lactobacilli species have been isolated in cases of bacteremia, sepsis, splenic abscess, endocarditis, necrotizing fasciitis, pancreatic necrosis, and meningoencephalitis.”

    Lactobacillus Delbrueckii · Natural Medicines adverse-effect record, reported in prostatitis.

    6 sources cited
    1. 107543. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
    2. 110917. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
    3. 110918. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
    4. 110920. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
    5. 110921. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
    6. 112553. Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed

    Brigatinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Brigatinib. Read the label on DailyMed ›

Reported for Lactobacillus Delbrueckii but not commonly for Brigatinib: trouble passing urine.

Effects for Brigatinib come from the ADVERSE REACTIONS section of its FDA label; effects for Lactobacillus Delbrueckii come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,630 voluntary FDA FAERS reports for Brigatinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Brigatinib

This page covers Lactobacillus Delbrueckii only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Brigatinib page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 40 minor.

From our pharmacist’s overview on the Brigatinib page

“Grapefruit is the first thing to cut if you take brigatinib (Alunbrig), a targeted therapy for ALK-positive lung cancer. It blocks the CYP3A4 enzyme that clears brigatinib, so drug levels can climb and side effects with them.”

Reviewed by 2 · Jul 18, 2026

Open the Brigatinib interaction page

One more smart check

Taking Lactobacillus Delbrueckii as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,200 real supplement products containing Lactobacillus Delbrueckii, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lactobacillus Delbrueckii. Even though Lactobacillus Delbrueckii itself has no known interaction with Brigatinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lactobacillus Delbrueckii and Brigatinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactobacillus Delbrueckii
Top 25%

#237 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Brigatinib
Top half

#1,198 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lactobacillus Delbrueckii reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Lactobacillus Delbrueckii and Brigatinib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lactobacillus Delbrueckii

What is Lactobacillus Delbrueckii?

  • Digestive health
  • Lactose digestion support
  • Diarrhea
  • Gut microbiome balance
  • Immune support

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy people, but solid human evidence for most specific health claims is limited. Talk to a pharmacist or doctor before using it, especially if you have a weakened immune system or serious illness.

Lactobacillus delbrueckii · Lactobacillaceae · Live bacterial cultures (the whole microorganism) · Capsules, tablets, powders, fermented dairy products (yogurt, cheese), and multi-strain probiotic blends

An interaction check asks whether these two react with each other — it does not ask whether Lactobacillus Delbrueckii is a good idea for someone in your situation. Here is what our Lactobacillus Delbrueckii record says about it on its own.

Lactobacillus Delbrueckii: dosing

There is no standardized, official dose of Lactobacillus delbrueckii. Probiotic products are usually measured in colony-forming units (CFU), and the amount varies widely between products.The best approach is to follow the directions on the product label and not exceed the recommended amount. Storing the product as directed (some need refrigeration) helps keep the bacteria alive and effective.

From our Lactobacillus Delbrueckii monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lactobacillus Delbrueckii monograph & all interactions
Medication

About Brigatinib

What Is Brigatinib Used For?

Brand name: Alunbrig

Alunbrig (brigatinib) is used to treat adults with ALK-positive metastatic non-small cell lung cancer (NSCLC) — a type of lung cancer that has spread and carries a specific genetic change in a protein called ALK. A doctor must confirm ALK positivity using an FDA-approved test before starting treatment.

Most-Reported Side Effects for Brigatinib

From FAERS, the FDA’s public side-effect reporting system (3,630 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Non-small cell lung cancer 395 reports
Diarrhea 253 reports
Metastases to central nervous system 242 reports
Nausea 232 reports
Lung neoplasm malignant 225 reports
See full Brigatinib drug information
Keep checking

Other Drugs & Lactobacillus Delbrueckii

Browse every other medication we’ve checked against Lactobacillus Delbrueckii — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
182Moderate
0Minor
2,647No known interaction
182 Moderate 2,647 No interaction
Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Lactobacillus Delbrueckii page.

No interaction 2,647 drugs checked — show the list

We also checked Lactobacillus Delbrueckii against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Lactobacillus Delbrueckii list.

See the full Lactobacillus Delbrueckii interactions page
See every supplement checked against Brigatinib, ranked by severity
Evidence & sources

Lactobacillus Delbrueckii References

The 9 references that drive our Lactobacillus Delbrueckii monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  7. Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed
  8. Maillet F, Passeron A, Podglajen I, Ranque B, Pouchot J. Lactobacillus delbrueckii urinary tract infection in a male patient. Med Mal Infect 2019;49(3):226-228. PubMed
  9. Darbro BW, Petroelje BK, Doern GV. Lactobacillus delbrueckii as the cause of urinary tract infection. J Clin Microbiol 2009;47(1):275-7.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lactobacillus Delbrueckii and Brigatinib Together: Common Questions

Is it safe to take Lactobacillus Delbrueckii with Brigatinib?
We do not list a known interaction between Lactobacillus Delbrueckii and Brigatinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Lactobacillus Delbrueckii and Brigatinib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Lactobacillus Delbrueckii and Brigatinib combination checked?
Interactions in our licensed database are recorded against drug classes. Brigatinib is filed under 3 classifications, and Lactobacillus Delbrueckii has documented interactions with 1 drug class — none of Brigatinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Lactobacillus Delbrueckii interact with any other medications?
Yes. Lactobacillus Delbrueckii has 182 documented drug interactions in our database — Brigatinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Brigatinib interact with any supplements?
Yes. Brigatinib has documented interactions with 143 supplements in our database — Lactobacillus Delbrueckii is not one of them. The Brigatinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lactobacillus Delbrueckii monograph Uses, safety profile, and every drug interaction in one place Brigatinib drug information The full plain-English guide to this medication Brigatinib supplement interactions Every supplement checked against Brigatinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Brigatinib and Lactobacillus Delbrueckii?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.