Drug & supplement interaction

Lady's Bedstraw + Spironolactone

Spironolactone brand names: Aldactone, Spiroton, Carospir.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lady's Bedstraw and Spironolactone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Lady's Bedstraw and Spironolactone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Spironolactone and Lady's Bedstraw in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lady's Bedstraw at all — not against Spironolactone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lady's Bedstraw safety at a glance

Lady's Bedstraw overall Use caution Generally considered mild in food-like amounts, but human safety data are very limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Spironolactone and Lady's Bedstraw? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Spironolactone’s Own FDA Label Lists

This is not an interaction — none of it involves Lady's Bedstraw. These are the most notable effects listed in the ADVERSE REACTIONS section of Spironolactone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • An electrolyte imbalance Worth acting on
  • High potassium Worth acting on
  • Low sodium Worth acting on
  • Unsteadiness Worth acting on
  • Confusion Worth acting on
  • A severe skin reaction Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Hives Worth acting on
  • A low white blood cell count Worth acting on

Showing the 10 most notable of 27 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Spironolactone. Read the label on DailyMed › Lady's Bedstraw’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Lady's Bedstraw side to compare — that is a limit of the record, not a statement that Lady's Bedstraw has no side effects.

From our Q&A

Questions About Lady's Bedstraw or Spironolactone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lady's Bedstraw or Spironolactone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Spironolactone

This page covers Lady's Bedstraw only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Spironolactone page lists 206 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 174 moderate · 25 minor.

From our pharmacist’s overview on the Spironolactone page

“Potassium is the supplement I check first for anyone on spironolactone (Aldactone, Carospir), because this water pill works by holding potassium in the body, and supplementing more on top of that can push blood levels too high. It is one of 206 supplement and herbal ingredients with documented interactions here, and the list warrants g…”

Reviewed by 2 · Jul 18, 2026

Open the Spironolactone interaction page

How much people look this up

Where Lady's Bedstraw and Spironolactone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lady's Bedstraw
Steady interest

#1,301 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Spironolactone
Top 5%

#113 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Lady's Bedstraw is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lady's Bedstraw reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lady's Bedstraw and Spironolactone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lady's Bedstraw

What is Lady's Bedstraw?

Lady's Bedstraw
  • Urinary and mild diuretic support
  • Skin complaints (topical)
  • Mild calming/sleep support
  • Digestive upset
  • Wound and inflammation soothing

Lady's bedstraw is a traditional European herb taken mostly as a tea for urinary, skin, and mild calming purposes. High-quality human research is lacking, so its benefits are not well proven, and you should talk with a pharmacist or doctor before using it—especially during pregnancy or breastfeeding.

Galium verum · Rubiaceae · Aerial parts (flowering tops, leaves, and stems) · Tea, infusion, tincture, dried herb, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Lady's Bedstraw is a good idea for someone in your situation. Here is what our Lady's Bedstraw record says about it on its own.

Lady's Bedstraw: dosing

There is no established or standardized dose for lady's bedstraw. Traditional use involves a tea made from the dried aerial parts, but exact safe and effective amounts have not been determined by research.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Lady's Bedstraw monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lady's Bedstraw monograph & all interactions
Medication

About Spironolactone

What Is Spironolactone Used For?

Brand names: Aldactone, Spiroton, Carospir

Spironolactone tablets (including Aldactone) are used to treat moderate-to-severe heart failure, high blood pressure, and fluid retention (edema) caused by liver cirrhosis or nephrotic syndrome. They are also used to diagnose and manage primary hyperaldosteronism — a condition where the adrenal glands produce too much of the hormone aldosterone.

Spironolactone oral suspension shares several of these uses — heart failure, high blood pressure, and edema from liver cirrhosis — but is not the same as Aldactone and is not therapeutically interchangeable with it. Your prescriber will choose the right form for your situation.

See full Spironolactone drug information
Keep checking

Other Drugs & Lady's Bedstraw

Browse every other medication we’ve checked against Lady's Bedstraw — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Lady's Bedstraw against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lady's Bedstraw list.

See the full Lady's Bedstraw interactions page
See every supplement checked against Spironolactone, ranked by severity
Evidence & sources

Lady's Bedstraw References

The 2 sources that drive our Lady's Bedstraw monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Lady's Bedstraw is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health (NCCIH) Source
  2. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lady's Bedstraw and Spironolactone Together: Common Questions

Is it safe to take Lady's Bedstraw with Spironolactone?
We do not list a known interaction between Lady's Bedstraw and Spironolactone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Spironolactone interact with any supplements?
Yes. Spironolactone has documented interactions with 206 supplements in our database — Lady's Bedstraw is not one of them. The Spironolactone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lady's Bedstraw monograph Uses, safety profile, and every drug interaction in one place Spironolactone drug information The full plain-English guide to this medication Spironolactone supplement interactions Every supplement checked against Spironolactone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Spironolactone and Lady's Bedstraw?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.