Drug & supplement interaction

Light Therapy + Tigecycline

Tigecycline brand name: Tygacil.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Light Therapy has a moderate interaction with Tigecycline. Light therapy may increase the risk for photosensitization.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Light Therapy and Tigecycline

Here is the interaction we found between these two, with the evidence behind it.

Moderate

PHOTOSENSITIZING DRUGS

Why this applies to Tigecycline

Tigecycline falls under PHOTOSENSITIZING DRUGS — the group Light Therapy interacts with.

Light therapy may increase the risk for photosensitization.
Concomitant use of photosensitizing drugs with light therapy may increase the risk for phototoxicity and should be avoided.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the connection worth knowing: tigecycline belongs to the tetracycline family, and these antibiotics can make your skin more sensitive to bright light. That's the photosensitivity issue. Light therapy, by design, exposes you to a lot of bright light, so in theory the two together could raise your odds of a sunburn-like skin reaction, redness, or irritation more easily than usual.

I'll be honest with you though, this is a theoretical concern based on how these medicines work, not something we see reported often. Tigecycline is also given by IV for short courses in serious infections, so the overlap is usually brief. Still, mention it to your pharmacist or doctor, and if your skin looks irritated during treatment, let them know.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pathirana, D., Ormerod, A. D., Saiag, P., Smith, C., Spuls, P. I., Nast, A., Barker, J., Bos, J. D., Burmester, G. R., Chimenti, S., Dubertret, L., Eberlein, B., Erdmann, R., Ferguson, J., Girolomoni, G., Gisondi, P., Giunta, A., Griffiths, C., Honigsmann
  2. Leon, A., Nguyen, A., Letsinger, J., and Koo, J. An attempt to formulate an evidence-based strategy in the management of moderate-to-severe psoriasis: a review of the efficacy and safety of biologics and prebiologic options. Expert Opin Pharmacother 2007; PubMed
  3. Morgan, M. and Khan, D. A. Therapeutic alternatives for chronic urticaria: an evidence-based review, Part 2. Ann Allergy Asthma Immunol 2008;100(6):517-526. PubMed
  4. Hoare, C., Li Wan, Po A., and Williams, H. Systematic review of treatments for atopic eczema. Health Technol Assess 2000;4(37):1-191. DOI
  5. Whitton, M. E., Pinart, M., Batchelor, J., Lushey, C., Leonardi-Bee, J., and Gonzalez, U. Interventions for vitiligo. Cochrane Database Syst Rev 2010;(1):CD003263. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Light Therapy Also Interacts With Other Medications

Light Therapy has 334 moderate known drug interactions in our database — the Tigecycline one above is one of them. If you take anything else, check it against the full list below.

Moderate 334 No known interaction 2,496 (incl. Tigecycline)
Taking anything else?

Check Another of Your Medications Against Light Therapy

Covers the 2,830 medications we’ve checked against Light Therapy. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Tigecycline

This page covers Light Therapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tigecycline page lists 98 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Oleander (major), Para-aminobenzoic Acid (paba) (major), Acerola (moderate), Alfalfa (moderate) and Alpha-lipoic Acid (moderate).

By severity: 2 major · 88 moderate · 8 minor.

From our pharmacist’s overview on the Tigecycline page

“Tigecycline (Tygacil) is an intravenous antibiotic usually reserved for serious or resistant infections, and its supplement list deserves real attention. The two major-rated entries come first: oleander, a heart-toxic plant whose compounds may build to dangerous levels with certain antibiotics on board, and PABA, which can blunt the an…”

Reviewed by 2 · Jul 18, 2026

Open the Tigecycline interaction page

How much people look this up

Where Light Therapy and Tigecycline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Light Therapy
Steady interest

#853 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tigecycline
Steady interest

#2,098 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Treatment approach

About Light Therapy

What is Light Therapy?

  • Seasonal affective disorder (SAD)
  • Non-seasonal depression
  • Sleep and circadian rhythm problems
  • Jet lag and shift-work sleep issues
  • Certain skin conditions

Light therapy uses controlled exposure to bright artificial light and is best supported for seasonal affective disorder, where it is a recognized treatment option. It is generally safe for most people when used as directed, but you should talk to a doctor or pharmacist first, especially if you have eye conditions, bipolar disorder, or take medicines that increase light sensitivity.

Read the full Light Therapy monograph & all interactions
Medication

About Tigecycline Injection

What Is Tigecycline Injection Used For?

Brand name: Tygacil

Tygacil (tigecycline for injection) is approved for adults 18 and older to treat three types of serious bacterial infections: complicated skin and skin structure infections, complicated intra-abdominal (stomach and intestinal) infections, and community-acquired bacterial pneumonia (pneumonia caught outside a hospital).

It is not approved for diabetic foot infections or for pneumonia caught in a hospital setting, including ventilator-associated pneumonia — clinical trials showed it did not work well enough for those uses and was associated with higher mortality in patients with ventilator-associated pneumonia.

See full Tigecycline Injection drug information
Keep checking

Other Drugs & Light Therapy

Browse every other medication we’ve checked against Light Therapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
334Moderate
0Minor
2,495No known interaction
334 Moderate 2,495 No interaction
Moderate

334 interactions

Showing 60 of 334 moderate interactions — see all 334 on the Light Therapy page.

No interaction 2,495 drugs checked — show the list

We also checked Light Therapy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,495 medications checked with no known interaction — see the full Light Therapy list.

See the full Light Therapy interactions page
See every supplement checked against Tigecycline, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Light Therapy monograph › Uses, safety, and every drug interaction in one place Tigecycline supplement interactions › Every supplement checked against Tigecycline, ranked by severity Tigecycline Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Having Light Therapy While Taking Tigecycline: Common Questions

Can you have Light Therapy while taking Tigecycline?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Light Therapy and Tigecycline interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tigecycline and Light Therapy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.