Medication interaction hub

What Supplements Interact with Tigecycline?

Tigecycline brand name: Tygacil. Every interaction below applies to the brands too.

98 Interactions 2 Major 88 Moderate 8 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tigecycline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tigecycline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tigecycline (Tygacil) is an intravenous antibiotic usually reserved for serious or resistant infections, and its supplement list deserves real attention. The two major-rated entries come first: oleander, a heart-toxic plant whose compounds may build to dangerous levels with certain antibiotics on board, and PABA, which can blunt the antibacterial effect of sulfonamide-type drugs. Most of the rest follows familiar patterns, probiotics the antibiotic can kill outright, ingredients that add to sun sensitivity, and minerals such as calcium that bind antibiotics in the gut and reduce absorption.

Probiotics are the easiest to manage; take them well apart from the antibiotic dose instead of together. Limit sun exposure if anything photosensitizing is in the mix, and be aware caffeine's effects can run stronger than usual. Of the 98 ingredients on file, 88 rate moderate and eight minor, leaving those two majors as the hazards to understand before all else.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 88 Minor 8 No known interaction 1,354

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Tigecycline: Top Interactions at a Glance

The Tigecycline supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 98 interacting ingredients — plus 1,354 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Tigecycline Combinations Today

The Tigecycline + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Bromelain + Tigecyclinei

Theoretically, bromelain might increase levels of tetracycline antibiotics.

Read the full interaction Moderate Likelihood Possible Riboflavin + Tigecyclinei

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.

Read the full interaction Moderate Likelihood Probable Whey Protein + Tigecyclinei

Theoretically, whey protein might decrease quinolone absorption.

Read the full interaction Moderate Likelihood Possible Alpha-lipoic Acid + Tigecyclinei

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.

Read the full interaction Major Likelihood Likely Para-aminobenzoic Acid (paba) + Tigecyclinei

Theoretically, concomitant use of PABA and sulfonamide antibiotics inhibits the antibacterial effects of sulfonamide.

Read the full interaction Major Likelihood Probable Oleander + Tigecyclinei

Theoretically, macrolide antibiotics may increase the risk of oleander toxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Tigecycline

All 1,452 ingredients in our database, ranked by severity — 98 with a Tigecycline interaction on file and 1,354 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tigecycline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bromelain with Tigecycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bromelain might increase levels of tetracycline antibiotics.

Full Bromelain + Tigecycline answer

Can you take Riboflavin with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.

Full Riboflavin + Tigecycline answer

Can you take Whey Protein with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, whey protein might decrease quinolone absorption.

Full Whey Protein + Tigecycline answer

Can you take Alpha-lipoic Acid with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.

Full Alpha-lipoic Acid + Tigecycline answer

Can you take Green Coffee with Tigecycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Full Green Coffee + Tigecycline answer

Can you take Guarana with Tigecycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Full Guarana + Tigecycline answer

Can you take Ilex Guayusa with Tigecycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Full Ilex Guayusa + Tigecycline answer

Can you take Oolong Tea with Tigecycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine in oolong tea.

Full Oolong Tea + Tigecycline answer

Can you take Pu-erh Tea with Tigecycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Full Pu-erh Tea + Tigecycline answer

Can you take Soy with Tigecycline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, antibiotics may decrease the activity of soy isoflavones.

Full Soy + Tigecycline answer

Can you take Para-aminobenzoic Acid (paba) with Tigecycline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of PABA and sulfonamide antibiotics inhibits the antibacterial effects of sulfonamide.

Full Para-aminobenzoic Acid (paba) + Tigecycline answer

Can you take Oleander with Tigecycline?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, macrolide antibiotics may increase the risk of oleander toxicity.

Full Oleander + Tigecycline answer

Can you take Bacillus Coagulans with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Tigecycline answer

Can you take Bacillus Subtilis with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Full Bacillus Subtilis + Tigecycline answer

Can you take Bergamot with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.

Full Bergamot + Tigecycline answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Tigecycline answer

Can you take Bifidobacterium Bifidum with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Tigecycline answer

Can you take Bifidobacterium Breve with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Tigecycline answer

Can you take Bifidobacterium Longum with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Tigecycline answer

Can you take Black Tea with Tigecycline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Full Black Tea + Tigecycline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tigecycline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tigecycline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tigecycline sits in 8 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Tigecycline through this category.

Quinolone Antibiotics 24 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

24 of the supplement ingredients on this page reach Tigecycline through this category.

Tetracycline Antibiotics 24 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

24 of the supplement ingredients on this page reach Tigecycline through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Tigecycline through this category.

Macrolide Antibiotics 11 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

11 of the supplement ingredients on this page reach Tigecycline through this category.

Antitumor Antibiotics 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Tigecycline through this category.

Sulfonamide Antibiotics 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Tigecycline through this category.

Aminoglycoside Antibiotics 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Tigecycline through this category.

About Tigecycline

Tigecycline injection is a tetracycline-class antibiotic given intravenously to treat serious bacterial infections of the skin, abdomen, and lungs in adults.

Generic name: Tigecycline  ·  Brand name: Tygacil.

See the full Tigecycline Injection drug information

Related: does Tigecycline deplete any nutrients?

Tigecycline has 16 reported nutrient associations in the research literature — see the Tigecycline nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tigecycline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tigecycline.

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Pharmacist Counseling Corner

Tigecycline & Supplements: Common Questions

What supplements interact with Tigecycline?
In our interaction database, 98 supplement and herbal ingredients have an interaction with Tigecycline on file — 2 rated major, 88 moderate, and 8 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Para-aminobenzoic Acid (paba), Oleander, Bacillus Coagulans.
Which Tigecycline supplement interactions are the most serious?
Focus on the major group: Para-aminobenzoic Acid (paba) and Oleander. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Tigecycline?
That depends entirely on which supplement. The honest answer for Tigecycline is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Tygacil have the same supplement interactions as Tigecycline?
Yes — Tygacil all contain Tigecycline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Tigecycline deplete any vitamins or nutrients?
It might — Tigecycline has 16 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Tigecycline nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Tigecycline and my other medications?
This page covers Tigecycline against supplements and herbal ingredients. Checking Tigecycline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tigecycline Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.