Drug & supplement interaction

Hedge Mustard + Tigecycline

Tigecycline brand name: Tygacil.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Tigecycline falls into 2 drug categories that Hedge Mustard can interact with; the most serious is rated moderate. Theoretically, taking hedge mustard with macrolide antibiotics might increase the risk of cardiac glycoside toxicity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Hedge Mustard and Tigecycline

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Hedge Mustard interacts with whole categories of medication. Tigecycline falls into 2 of those categories, so it can interact with Hedge Mustard in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

MACROLIDE ANTIBIOTICS

1 of 2

Why this applies to Tigecycline

Tigecycline falls under MACROLIDE ANTIBIOTICS — the group Hedge Mustard interacts with.

Theoretically, taking hedge mustard with macrolide antibiotics might increase the risk of cardiac glycoside toxicity.

The flowering above ground parts of hedge mustard contain cardioactive glycosides. Macrolide antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of macrolide antibiotics might increase the absorption of the cardiac glycosides found in hedge mustard.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here is the thing to keep in mind about this pairing. Hedge mustard's above-ground parts contain natural cardiac glycosides, plant chemicals that act a bit like the heart drug digoxin. The concern on file is that certain antibiotics may boost how much of these heart-active compounds your gut absorbs, which could in theory push you toward glycoside toxicity (think nausea, a slow or irregular heartbeat, dizziness, or vision changes).

I want to be honest about the strength of this, though. It is purely theoretical, based on how the chemistry might behave, not on real cases with tigecycline (which is a tetracycline-type antibiotic given in the hospital by IV, not a macrolide). Tigecycline is not a prodrug here, so nothing flips. Still, since hedge mustard is an unproven folk remedy, it is worth a quick word with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Moderate

TETRACYCLINE ANTIBIOTICS

2 of 2

Tigecycline also falls under TETRACYCLINE ANTIBIOTICS.

Theoretically, taking hedge mustard with tetracycline antibiotics might increase the risk of cardiac glycoside toxicity.

The flowering above ground parts of hedge mustard contain cardioactive glycosides. Tetracycline antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of tetracycline antibiotics might increase the absorption of the cardiac glycosides found in hedge mustard.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing about this pairing: the worry isn't really about the tigecycline itself, it's about the hedge mustard. The flowering parts of hedge mustard contain natural heart-active compounds called cardiac glycosides (the same family as the heart medicine digoxin). Tetracycline-type antibiotics, which tigecycline belongs to, may bump up how much of these compounds your gut absorbs. So in theory, taking them together could let more of the herb's heart-active chemicals into your body.

I want to be honest though, this is theoretical and based on how these things work on paper, not on real patient reports. Tigecycline is also given by IV in the hospital, usually short-term, so this concern is small. Still, if you're using hedge mustard, mention it to your pharmacist or doctor so they're in the loop.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Hedge Mustard Also Interacts With Other Medications

Hedge Mustard has 132 moderate known drug interactions in our database — the Tigecycline one above is among them. If you take anything else, check it against the full list below.

Moderate 132 No known interaction 2,698 (incl. Tigecycline)
Taking anything else?

Check Another of Your Medications Against Hedge Mustard

Covers the 2,830 medications we’ve checked against Hedge Mustard. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Tigecycline

This page covers Hedge Mustard only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tigecycline page lists 98 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Oleander (major), Para-aminobenzoic Acid (paba) (major), Acerola (moderate), Alfalfa (moderate) and Alpha-lipoic Acid (moderate).

By severity: 2 major · 88 moderate · 8 minor.

From our pharmacist’s overview on the Tigecycline page

“Tigecycline (Tygacil) is an intravenous antibiotic usually reserved for serious or resistant infections, and its supplement list deserves real attention. The two major-rated entries come first: oleander, a heart-toxic plant whose compounds may build to dangerous levels with certain antibiotics on board, and PABA, which can blunt the an…”

Reviewed by 2 · Jul 18, 2026

Open the Tigecycline interaction page

How much people look this up

Where Hedge Mustard and Tigecycline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hedge Mustard
Steady interest

#1,040 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tigecycline
Steady interest

#2,500 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Hedge Mustard

What is Hedge Mustard?

  • Hoarseness and voice loss
  • Sore throat
  • Cough
  • Mild laryngitis
  • Throat irritation

Hedge mustard is a traditional European herb long nicknamed the 'singer's plant' because it was used to soothe hoarseness and sore throats. Solid scientific evidence for these uses is very limited, so it is best seen as a folk remedy rather than a proven treatment. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Hedge Mustard monograph & all interactions
Medication

About Tigecycline Injection

What Is Tigecycline Injection Used For?

Brand name: Tygacil

Tygacil (tigecycline for injection) is approved for adults 18 and older to treat three types of serious bacterial infections: complicated skin and skin structure infections, complicated intra-abdominal (stomach and intestinal) infections, and community-acquired bacterial pneumonia (pneumonia caught outside a hospital).

It is not approved for diabetic foot infections or for pneumonia caught in a hospital setting, including ventilator-associated pneumonia — clinical trials showed it did not work well enough for those uses and was associated with higher mortality in patients with ventilator-associated pneumonia.

See full Tigecycline Injection drug information
Keep checking

Other Drugs & Hedge Mustard

Browse every other medication we’ve checked against Hedge Mustard — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
132Moderate
0Minor
2,697No known interaction
132 Moderate 2,697 No interaction
Moderate

132 interactions

Showing 60 of 132 moderate interactions — see all 132 on the Hedge Mustard page.

No interaction 2,697 drugs checked — show the list

We also checked Hedge Mustard against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,697 medications checked with no known interaction — see the full Hedge Mustard list.

See the full Hedge Mustard interactions page
See every supplement checked against Tigecycline, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Hedge Mustard monograph › Uses, safety, and every drug interaction in one place Tigecycline supplement interactions › Every supplement checked against Tigecycline, ranked by severity Tigecycline Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Hedge Mustard and Tigecycline Together: Common Questions

Can you take Hedge Mustard with Tigecycline?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Hedge Mustard and Tigecycline?
Tigecycline belongs to more than one drug category, and Hedge Mustard interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Hedge Mustard and Tigecycline interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.