Drug & supplement interaction

Dolomite + Tigecycline

Tigecycline brand name: Tygacil.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Tigecycline falls into 2 drug categories that Dolomite can interact with; the most serious is rated moderate. Theoretically, the magnesium in dolomite might decrease the absorption of quinolone antibiotics.

Read the full interaction report
SeverityModerate
LikelihoodProbable
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Dolomite and Tigecycline

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Dolomite interacts with whole categories of medication. Tigecycline falls into 2 of those categories, so it can interact with Dolomite in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

QUINOLONE ANTIBIOTICS

1 of 2

Why this applies to Tigecycline

Tigecycline falls under QUINOLONE ANTIBIOTICS — the group Dolomite interacts with.

Theoretically, the magnesium in dolomite might decrease the absorption of quinolone antibiotics.
Dolomite contains magnesium, which can form insoluble complexes with quinolones in the gut. Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after dolomite.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's something worth knowing about this pairing. The concern on file is that the calcium and magnesium in dolomite can bind to certain antibiotics in the gut and block their absorption, which would weaken the drug and let an infection linger. That binding issue is very real for pills you swallow.

But here's the key point for tigecycline (Tygacil): it's only given as an injection into a vein, not as a tablet you take by mouth. Since it never travels through your stomach with the dolomite, this gut-binding interaction essentially doesn't apply here. The note in our database is really aimed at oral antibiotics. Still, dolomite can contain trace heavy metals, so I'd run any supplement past your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
Moderate

TETRACYCLINE ANTIBIOTICS

2 of 2

Tigecycline also falls under TETRACYCLINE ANTIBIOTICS.

Theoretically, the calcium and magnesium in dolomite might decrease the absorption of tetracycline antibiotics.
Dolomite contains calcium and magnesium, which can bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after dolomite.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's some good news that takes the worry out of this one: tigecycline (Tygacil) is given as an IV infusion, not as a pill you swallow. The concern with dolomite is that its calcium and magnesium can grab onto tetracycline antibiotics in your gut and keep them from being absorbed. Since tigecycline goes straight into a vein, there's nothing in your stomach for the dolomite to bind to, so this particular interaction really doesn't apply the way it would with an oral tetracycline.

This caution is theoretical and aimed at swallowed tetracyclines. Even so, I'd steer you away from dolomite in general, since these products can be contaminated with lead and other heavy metals. If you want calcium or magnesium, ask your pharmacist for a safer, better-tested option.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Dolomite Also Interacts With Other Medications

Dolomite has 56 major, 71 moderate known drug interactions in our database — the Tigecycline one above is among them. If you take anything else, check it against the full list below.

Major 56 Moderate 71 No known interaction 2,703 (incl. Tigecycline)
Taking anything else?

Check Another of Your Medications Against Dolomite

Covers the 2,830 medications we’ve checked against Dolomite. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Tigecycline

This page covers Dolomite only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tigecycline page lists 98 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Oleander (major), Para-aminobenzoic Acid (paba) (major), Acerola (moderate), Alfalfa (moderate) and Alpha-lipoic Acid (moderate).

By severity: 2 major · 88 moderate · 8 minor.

From our pharmacist’s overview on the Tigecycline page

“Tigecycline (Tygacil) is an intravenous antibiotic usually reserved for serious or resistant infections, and its supplement list deserves real attention. The two major-rated entries come first: oleander, a heart-toxic plant whose compounds may build to dangerous levels with certain antibiotics on board, and PABA, which can blunt the an…”

Reviewed by 2 · Jul 18, 2026

Open the Tigecycline interaction page

One more smart check

Taking Dolomite as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Dolomite, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dolomite. Your product may carry other ingredients that interact with Tigecycline too, on top of Dolomite — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dolomite and Tigecycline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dolomite
Steady interest

#780 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tigecycline
Steady interest

#2,529 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Dolomite

What is Dolomite?

Dolomite
  • Source of calcium
  • Source of magnesium
  • Bone health support
  • Antacid for heartburn
  • Mineral supplementation

Dolomite is a natural mineral that provides both calcium and magnesium. However, many health authorities advise against using it because dolomite products have been found to contain heavy metals like lead, arsenic, and mercury, and safer, better-tested calcium and magnesium supplements are widely available.

Read the full Dolomite monograph & all interactions
Medication

About Tigecycline Injection

What Is Tigecycline Injection Used For?

Brand name: Tygacil

Tygacil (tigecycline for injection) is approved for adults 18 and older to treat three types of serious bacterial infections: complicated skin and skin structure infections, complicated intra-abdominal (stomach and intestinal) infections, and community-acquired bacterial pneumonia (pneumonia caught outside a hospital).

It is not approved for diabetic foot infections or for pneumonia caught in a hospital setting, including ventilator-associated pneumonia — clinical trials showed it did not work well enough for those uses and was associated with higher mortality in patients with ventilator-associated pneumonia.

See full Tigecycline Injection drug information
Keep checking

Other Drugs & Dolomite

Browse every other medication we’ve checked against Dolomite — both the ones with a known interaction and the ones without. Select any drug for the full detail.

56Major
71Moderate
0Minor
2,702No known interaction
56 Major 71 Moderate 2,702 No interaction
Major

56 interactions

Moderate

71 interactions

Showing 60 of 71 moderate interactions — see all 71 on the Dolomite page.

No interaction 2,702 drugs checked — show the list

We also checked Dolomite against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,702 medications checked with no known interaction — see the full Dolomite list.

See the full Dolomite interactions page
See every supplement checked against Tigecycline, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Dolomite monograph › Uses, safety, and every drug interaction in one place Tigecycline supplement interactions › Every supplement checked against Tigecycline, ranked by severity Tigecycline Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Dolomite and Tigecycline Together: Common Questions

Can you take Dolomite with Tigecycline?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Dolomite and Tigecycline?
Tigecycline belongs to more than one drug category, and Dolomite interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Dolomite and Tigecycline interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tigecycline and Dolomite?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.