Drug & supplement interaction

Dolomite + Polythiazide, Prazosin

Polythiazide, Prazosin brand name: Minizide.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Dolomite has a major interaction with Polythiazide, Prazosin. Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.

Read the full interaction report
SeverityMajor
LikelihoodProbable
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Dolomite and Polythiazide, Prazosin

Here is the interaction we found between these two, with the evidence behind it.

Major

THIAZIDE DIURETICS

Why this applies to Polythiazide, Prazosin

Polythiazide, Prazosin falls under THIAZIDE DIURETICS — the group Dolomite interacts with.

Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.
Dolomite contains calcium, and thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of dolomite increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, kidney failure).
Severity Major Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Minizide is a combination pill that contains polythiazide, a thiazide-type water pill, along with prazosin for blood pressure. The piece that matters here is the thiazide. Thiazides make your kidneys hold onto calcium instead of flushing it out. Dolomite, meanwhile, is a calcium and magnesium source. Stack the two together in larger amounts and your calcium can climb too high, which can lead to a problem called milk-alkali syndrome (high calcium, an upset acid balance, and even kidney trouble).

Warning signs of high calcium include nausea, constipation, feeling unusually thirsty, confusion, or weakness. On top of that, dolomite can carry heavy metals like lead, so it's not a supplement I'd recommend anyway. Please don't change your Minizide on your own. Talk with your pharmacist or doctor before adding any calcium product.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Dolomite Also Interacts With Other Medications

Dolomite has 55 major, 72 moderate known drug interactions in our database — the Polythiazide, Prazosin one above is one of them. If you take anything else, check it against the full list below.

Major 55 Moderate 72 No known interaction 2,703 (incl. Polythiazide, Prazosin)
Taking anything else?

Check Another of Your Medications Against Dolomite

Covers the 2,830 medications we’ve checked against Dolomite. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Polythiazide, Prazosin

This page covers Dolomite only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Polythiazide, Prazosin page lists 228 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Lithium (major).

By severity: 10 major · 193 moderate · 25 minor.

From our pharmacist’s overview on the Polythiazide, Prazosin page

“Minizide pairs polythiazide, a water pill, with prazosin to lower blood pressure, and this list calls for real vigilance rather than a quick skim. Of the 228 supplement and herbal ingredients on file, 10 carry a major rating, and those deserve your attention first.”

Reviewed by 2 · Jul 18, 2026

Open the Polythiazide, Prazosin interaction page

One more smart check

Taking Dolomite as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Dolomite, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dolomite. Your product may carry other ingredients that interact with Polythiazide, Prazosin too, on top of Dolomite — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dolomite and Polythiazide, Prazosin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dolomite
Top half

#685 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Polythiazide, Prazosin
Steady interest

#2,618 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Dolomite

What is Dolomite?

Dolomite
  • Source of calcium
  • Source of magnesium
  • Bone health support
  • Antacid for heartburn
  • Mineral supplementation

Dolomite is a natural mineral that provides both calcium and magnesium. However, many health authorities advise against using it because dolomite products have been found to contain heavy metals like lead, arsenic, and mercury, and safer, better-tested calcium and magnesium supplements are widely available.

Read the full Dolomite monograph & all interactions
Keep checking

Other Drugs & Dolomite

Browse every other medication we’ve checked against Dolomite — both the ones with a known interaction and the ones without. Select any drug for the full detail.

55Major
72Moderate
0Minor
2,702No known interaction
55 Major 72 Moderate 2,702 No interaction
Major

55 interactions

Moderate

72 interactions

Showing 60 of 72 moderate interactions — see all 72 on the Dolomite page.

No interaction 2,702 drugs checked — show the list

We also checked Dolomite against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,702 medications checked with no known interaction — see the full Dolomite list.

See the full Dolomite interactions page
See every supplement checked against Polythiazide, Prazosin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Dolomite monograph › Uses, safety, and every drug interaction in one place Polythiazide, Prazosin supplement interactions › Every supplement checked against Polythiazide, Prazosin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Dolomite and Polythiazide, Prazosin Together: Common Questions

Can you take Dolomite with Polythiazide, Prazosin?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Dolomite and Polythiazide, Prazosin interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Polythiazide, Prazosin and Dolomite?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.