Drug & supplement interaction

Dolomite + Hydrochlorothiazide, Spironolactone

Hydrochlorothiazide, Spironolactone brand names: Spirozine, Aldactazide, Aldactide 25, Aldactide 50.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Hydrochlorothiazide, Spironolactone falls into 2 drug categories that Dolomite can interact with; the most serious is rated major. Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.

Read the full interaction report
SeverityMajor
LikelihoodProbable
Interactions2
EvidenceC
What do Severity, Likelihood & Evidence mean?
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Interaction report

Dolomite and Hydrochlorothiazide, Spironolactone

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Dolomite interacts with whole categories of medication. Hydrochlorothiazide, Spironolactone falls into 2 of those categories, so it can interact with Dolomite in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Major).

Major

THIAZIDE DIURETICS

1 of 2

Why this applies to Hydrochlorothiazide, Spironolactone

Hydrochlorothiazide, Spironolactone falls under THIAZIDE DIURETICS — the group Dolomite interacts with.

Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.
Dolomite contains calcium, and thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of dolomite increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, kidney failure).
Severity Major Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to watch with your combo pill: the hydrochlorothiazide part makes your kidneys hold onto calcium instead of flushing it out. Dolomite is loaded with calcium, so pairing the two can let calcium climb too high in your blood. In larger amounts this can lead to what's called milk-alkali syndrome, which means high calcium, an acid-base imbalance, and even kidney trouble.

Signs to know: nausea, constipation, feeling unusually thirsty, confusion, or weakness. On top of that, dolomite can carry heavy metals like lead, so it's not a supplement I'd reach for anyway. Please don't change your blood pressure pill, but do check with your pharmacist or doctor before taking dolomite, and ask about a cleaner calcium option if you need one.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
Moderate

POTASSIUM-SPARING DIURETICS

2 of 2

Hydrochlorothiazide, Spironolactone also falls under POTASSIUM-SPARING DIURETICS.

Theoretically, serum magnesium levels might increase when dolomite is taken with potassium-sparing diuretics.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Dolomite contains magnesium, which may increase the risk for hypermagnesemia.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your combo pill pairs hydrochlorothiazide with spironolactone. The spironolactone half is what matters here. While a plain water pill (the thiazide) tends to flush out magnesium, spironolactone actually helps your body hold onto magnesium. Since dolomite supplies extra magnesium, the worry is that levels could slowly climb higher than they should, a state called hypermagnesemia.

I'll be honest: this is a theoretical concern based on how these work, not something seen often in real patients with healthy kidneys. Still, signs of too much magnesium include feeling unusually tired, weak, flushed, or having a slow heartbeat. If your kidneys are weak, the risk is higher. Please don't stop anything, just run dolomite by your pharmacist or doctor first, since safer calcium and magnesium options exist.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ryan MP. Diuretics and potassium/magnesium depletion. Directions for treatment. Am J Med 1987;82:38-47.. PubMed
  2. Hollifield JW. Magnesium depletion, diuretics, and arrhythmias. Am J Med 1987;82:30-7.. PubMed
  3. Heidenreich O. Mode of action of conventional and potassium-sparing diuretics--aspects with relevance to Mg-sparing effects. Magnesium 1984;3:248-56..

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Dolomite Also Interacts With Other Medications

Dolomite has 55 major, 72 moderate known drug interactions in our database — the Hydrochlorothiazide, Spironolactone one above is among them. If you take anything else, check it against the full list below.

Major 55 Moderate 72 No known interaction 2,703 (incl. Hydrochlorothiazide, Spironolactone)
Taking anything else?

Check Another of Your Medications Against Dolomite

Covers the 2,830 medications we’ve checked against Dolomite. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Spironolactone

This page covers Dolomite only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Spironolactone page lists 235 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Lithium (major).

By severity: 10 major · 199 moderate · 26 minor.

From our pharmacist’s overview on the Hydrochlorothiazide, Spironolactone page

“Hydrochlorothiazide with spironolactone (Aldactazide) deserves genuine care around supplements, and the ten major-rated interactions on this list of 235 are the ones to understand before anything else. Most entries either add to the drug's blood-pressure-lowering effect, sometimes enough to cause dizziness or fainting, or amplify its d…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide, Spironolactone interaction page

One more smart check

Taking Dolomite as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Dolomite, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dolomite. Your product may carry other ingredients that interact with Hydrochlorothiazide, Spironolactone too, on top of Dolomite — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dolomite and Hydrochlorothiazide, Spironolactone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dolomite
Top half

#678 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide, Spironolactone
Top 25%

#522 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Dolomite

What is Dolomite?

Dolomite
  • Source of calcium
  • Source of magnesium
  • Bone health support
  • Antacid for heartburn
  • Mineral supplementation

Dolomite is a natural mineral that provides both calcium and magnesium. However, many health authorities advise against using it because dolomite products have been found to contain heavy metals like lead, arsenic, and mercury, and safer, better-tested calcium and magnesium supplements are widely available.

Read the full Dolomite monograph & all interactions
Keep checking

Other Drugs & Dolomite

Browse every other medication we’ve checked against Dolomite — both the ones with a known interaction and the ones without. Select any drug for the full detail.

55Major
72Moderate
0Minor
2,702No known interaction
55 Major 72 Moderate 2,702 No interaction
Major

55 interactions

Moderate

72 interactions

Showing 60 of 72 moderate interactions — see all 72 on the Dolomite page.

No interaction 2,702 drugs checked — show the list

We also checked Dolomite against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,702 medications checked with no known interaction — see the full Dolomite list.

See the full Dolomite interactions page
See every supplement checked against Hydrochlorothiazide, Spironolactone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Dolomite monograph › Uses, safety, and every drug interaction in one place Hydrochlorothiazide, Spironolactone supplement interactions › Every supplement checked against Hydrochlorothiazide, Spironolactone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Dolomite and Hydrochlorothiazide, Spironolactone Together: Common Questions

Can you take Dolomite with Hydrochlorothiazide, Spironolactone?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Dolomite and Hydrochlorothiazide, Spironolactone?
Hydrochlorothiazide, Spironolactone belongs to more than one drug category, and Dolomite interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Dolomite and Hydrochlorothiazide, Spironolactone interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydrochlorothiazide, Spironolactone and Dolomite?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.