Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Spironolactone?

Hydrochlorothiazide, Spironolactone brand names: Spirozine, Aldactazide, Aldactide 25, Aldactide 50. Every interaction below applies to the brands too.

235 Interactions 10 Major 199 Moderate 26 Minor
Curated & coded by · Clinical Pharmacist · Updated September 26, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Spironolactone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Spironolactone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Hydrochlorothiazide with spironolactone (Aldactazide) deserves genuine care around supplements, and the ten major-rated interactions on this list of 235 are the ones to understand before anything else. Most entries either add to the drug's blood-pressure-lowering effect, sometimes enough to cause dizziness or fainting, or amplify its diuretic action and throw off fluid and electrolyte balance. A smaller cluster can strain the kidneys outright, which matters for a medication the kidneys handle.

Potassium supplements sit in an odd spot here, since spironolactone already holds potassium back and adding more risks dangerously high levels. Calcium products create the opposite problem with the thiazide half, pushing calcium too far up. Activated charcoal, an everyday remedy, can simply block the pill's absorption. Beyond the ten majors, 199 entries rate moderate and 26 minor, and about twenty add sun sensitivity worth remembering in summer months.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 199 Minor 26 No known interaction 1,217

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrochlorothiazide, Spironolactone: Top Interactions at a Glance

The Hydrochlorothiazide, Spironolactone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 235 interacting ingredients — plus 1,217 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrochlorothiazide, Spironolactone Combinations Today

The Hydrochlorothiazide, Spironolactone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Hedge Mustard + Hydrochlorothiazide, Spironolactonei

Theoretically, taking hedge mustard with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Read the full interaction Minor Likelihood Possible Karaya Gum + Hydrochlorothiazide, Spironolactonei

Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs.

Read the full interaction Minor Likelihood Likely Thyroid Extract + Hydrochlorothiazide, Spironolactonei

Food and medications can interfere with thyroid hormone absorption.

Read the full interaction Moderate Likelihood Possible Slippery Elm + Hydrochlorothiazide, Spironolactonei

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Read the full interaction Major Likelihood Likely American Hellebore + Hydrochlorothiazide, Spironolactonei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Hydrochlorothiazide, Spironolactonei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Spironolactone

All 1,452 ingredients in our database, ranked by severity — 235 with a Hydrochlorothiazide, Spironolactone interaction on file and 1,217 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Spironolactone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hedge Mustard with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hedge mustard with diuretic drugs might increase the risk of cardiac glycoside toxicity.

Full Hedge Mustard + Hydrochlorothiazide, Spironolactone answer

Can you take Karaya Gum with Hydrochlorothiazide, Spironolactone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Hydrochlorothiazide, Spironolactone answer

Can you take Thyroid Extract with Hydrochlorothiazide, Spironolactone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Hydrochlorothiazide, Spironolactone answer

Can you take Slippery Elm with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Hydrochlorothiazide, Spironolactone answer

Can you take Gossypol with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gossypol might increase the risk of hypokalemia when taken with potassium-depleting diuretic drugs.

Full Gossypol + Hydrochlorothiazide, Spironolactone answer

Can you take Green Coffee with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of hypokalemia.

Full Green Coffee + Hydrochlorothiazide, Spironolactone answer

Can you take Green Tea with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using green tea with diuretic drugs might increase the risk of hypokalemia.

Full Green Tea + Hydrochlorothiazide, Spironolactone answer

Can you take Guar Gum with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Hydrochlorothiazide, Spironolactone answer

Can you take Guarana with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using guarana with diuretic drugs might increase the risk of hypokalemia.

Full Guarana + Hydrochlorothiazide, Spironolactone answer

Can you take Guarumo with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that aqueous and ethanolic extracts of guarumo leaf can lower blood pressure when administered intrav...

Full Guarumo + Hydrochlorothiazide, Spironolactone answer

Can you take Gum Arabic with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Hydrochlorothiazide, Spironolactone answer

Can you take Hesperidin with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.

Full Hesperidin + Hydrochlorothiazide, Spironolactone answer

Can you take Hibiscus Sabdariffa with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Hibiscus sabdariffa with antihypertensive drugs might increase the risk of hypotension.

Full Hibiscus Sabdariffa + Hydrochlorothiazide, Spironolactone answer

Can you take Hoodia with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research shows that hoodia can increase blood pressure.

Full Hoodia + Hydrochlorothiazide, Spironolactone answer

Can you take Horny Goat Weed with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the risk of hypotension.

Full Horny Goat Weed + Hydrochlorothiazide, Spironolactone answer

Can you take Horsetail with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.

Full Horsetail + Hydrochlorothiazide, Spironolactone answer

Can you take Ilex Guayusa with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of hypokalemia.

Full Ilex Guayusa + Hydrochlorothiazide, Spironolactone answer

Can you take Indian Cassia with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian cassia might increase the risk of potassium depletion in patients taking diuretic drugs.

Full Indian Cassia + Hydrochlorothiazide, Spironolactone answer

Can you take Indian Snakeroot with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Indian snakeroot and antihypertensive drugs might increase the risk of hypotension.

Full Indian Snakeroot + Hydrochlorothiazide, Spironolactone answer

Can you take Isopropylnorsynephrine with Hydrochlorothiazide, Spironolactone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, isopropylnorsynephrine might decrease the effects of antihypertensive drugs.

Full Isopropylnorsynephrine + Hydrochlorothiazide, Spironolactone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Spironolactone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Spironolactone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Spironolactone sits in 9 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Spironolactone through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Spironolactone through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Spironolactone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Spironolactone through this category.

Potassium-Sparing Diuretics 8 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

8 of the supplement ingredients on this page reach Hydrochlorothiazide, Spironolactone through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Spironolactone through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Spironolactone through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Spironolactone through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Spironolactone through this category.

Related: does Hydrochlorothiazide, Spironolactone deplete any nutrients?

Hydrochlorothiazide, Spironolactone has 36 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Spironolactone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Spironolactone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Spironolactone.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Spironolactone & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Spironolactone?
In our interaction database, 235 supplement and herbal ingredients have an interaction with Hydrochlorothiazide, Spironolactone on file — 10 rated major, 199 moderate, and 26 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide, Spironolactone supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Spironolactone?
That depends entirely on which supplement. The honest answer for Hydrochlorothiazide, Spironolactone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Spirozine have the same supplement interactions as Hydrochlorothiazide, Spironolactone?
Yes — Spirozine, Aldactazide, Aldactide 25, Aldactide 50 all contain Hydrochlorothiazide, Spironolactone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Spironolactone deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Spironolactone has 36 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Spironolactone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Spironolactone and my other medications?
This page covers Hydrochlorothiazide, Spironolactone against supplements and herbal ingredients. Checking Hydrochlorothiazide, Spironolactone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 26, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.