Drug & supplement interaction

Dandelion + Hydrochlorothiazide, Spironolactone

Hydrochlorothiazide, Spironolactone brand names: Spirozine, Aldactazide, Aldactide 25, Aldactide 50.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Dandelion has a moderate interaction with Hydrochlorothiazide, Spironolactone. Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Dandelion and Hydrochlorothiazide, Spironolactone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

POTASSIUM-SPARING DIURETICS

Why this applies to Hydrochlorothiazide, Spironolactone

Hydrochlorothiazide, Spironolactone falls under POTASSIUM-SPARING DIURETICS — the group Dandelion interacts with.

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing about your combination pill: the spironolactone part is a potassium-sparing diuretic, which means it tends to hold onto potassium rather than flush it out. Dandelion happens to contain a fair bit of potassium itself. So in theory, pairing the two could nudge your potassium level higher than you'd want, a state called hyperkalemia.

I want to be honest with you, though. This concern comes from lab-based reasoning, not solid human studies, so it's more of a 'be aware' than a 'be alarmed.' A little dandelion in a salad or tea is unlikely to matter much. Concentrated dandelion supplements are the bigger question mark. High potassium can cause muscle weakness, tingling, or an irregular heartbeat, so check with your pharmacist or doctor before adding a dandelion supplement, and keep up with any potassium blood tests they order.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996;42:121-7. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Dandelion Also Interacts With Other Medications

Dandelion has 456 moderate known drug interactions in our database — the Hydrochlorothiazide, Spironolactone one above is one of them. If you take anything else, check it against the full list below.

Moderate 456 No known interaction 2,374 (incl. Hydrochlorothiazide, Spironolactone)
Taking anything else?

Check Another of Your Medications Against Dandelion

Covers the 2,830 medications we’ve checked against Dandelion. Pick one to open its full report.

From our Q&A

Questions About Dandelion or Hydrochlorothiazide, Spironolactone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Dandelion or Hydrochlorothiazide, Spironolactone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide, Spironolactone

This page covers Dandelion only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide, Spironolactone page lists 235 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 199 moderate · 26 minor.

From our pharmacist’s overview on the Hydrochlorothiazide, Spironolactone page

“Hydrochlorothiazide with spironolactone (Aldactazide) deserves genuine care around supplements, and the ten major-rated interactions on this list of 235 are the ones to understand before anything else. Most entries either add to the drug's blood-pressure-lowering effect, sometimes enough to cause dizziness or fainting, or amplify its d…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide, Spironolactone interaction page

One more smart check

Taking Dandelion as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,328 real supplement products containing Dandelion, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dandelion. Your product may carry other ingredients that interact with Hydrochlorothiazide, Spironolactone too, on top of Dandelion — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dandelion and Hydrochlorothiazide, Spironolactone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dandelion
Top 5%

#54 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide, Spironolactone
Top 25%

#295 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Dandelion

What is Dandelion?

Dandelion
  • Water retention (diuretic)
  • Digestive upset
  • Liver and gallbladder support
  • Mild appetite stimulant
  • Skin conditions

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits are not well proven. It is generally considered safe as a food, but talk to your pharmacist or doctor before using concentrated supplements, especially if you have allergies or take other medicines.

Read the full Dandelion monograph & all interactions
Keep checking

Other Drugs & Dandelion

Browse every other medication we’ve checked against Dandelion — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
456Moderate
0Minor
2,373No known interaction
456 Moderate 2,373 No interaction
Moderate

456 interactions

Showing 60 of 456 moderate interactions — see all 456 on the Dandelion page.

No interaction 2,373 drugs checked — show the list

We also checked Dandelion against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,373 medications checked with no known interaction — see the full Dandelion list.

See the full Dandelion interactions page
See every supplement checked against Hydrochlorothiazide, Spironolactone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Dandelion monograph › Uses, safety, and every drug interaction in one place Hydrochlorothiazide, Spironolactone supplement interactions › Every supplement checked against Hydrochlorothiazide, Spironolactone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Dandelion and Hydrochlorothiazide, Spironolactone Together: Common Questions

Can you take Dandelion with Hydrochlorothiazide, Spironolactone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Dandelion and Hydrochlorothiazide, Spironolactone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydrochlorothiazide, Spironolactone and Dandelion?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.