Drug & supplement interaction

Liver Extract + Itraconazole

Itraconazole brand names: Sporanox, Sporanox Injection, Tolsura.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Liver Extract and Itraconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Liver Extract and Itraconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Itraconazole and Liver Extract in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Liver Extract safety at a glance

Liver Extract overall Use caution Generally low risk for healthy adults in food amounts, but it can deliver high levels of vitamin A and iron and carries source-quality concerns.
Pregnancy Use caution Liver products can contain very high vitamin A, which may harm a developing baby, so avoid unless advised by your doctor.
Breastfeeding Use caution Safety has not been well studied; check with your doctor before using.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Itraconazole and Liver Extract? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Itraconazole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Itraconazole is filed under 8 classifications — including antifungals, cytochrome p450 2c9 (cyp2c9) inhibitors, cytochrome p450 3a4 (cyp3a4) inhibitors. Liver Extract has documented interactions with 2 drug classes — the most serious being iron (minor) and warfarin (coumadin) (minor) — and none of Itraconazole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Liver Extract Does Interact With Other Medications

Liver Extract has 3 minor known drug interactions in our database — Itraconazole isn’t one of them. If you take anything else, check it against the full list below.

Minor 3 No known interaction 2,827 (incl. Itraconazole)
Taking anything else?

Check Another of Your Medications Against Liver Extract

Covers the 2,830 medications we’ve checked against Liver Extract. Pick one to open its full report.

What to actually watch for

What Itraconazole’s Own FDA Label Lists

This is not an interaction — none of it involves Liver Extract. These are the most notable effects listed in the ADVERSE REACTIONS section of Itraconazole’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Low magnesium Worth acting on
  • Hearing loss Worth acting on
  • Severe muscle breakdown Worth acting on
  • Dehydration Worth acting on
  • Trouble swallowing Worth acting on
  • High potassium Worth acting on
  • Low potassium Worth acting on
  • A slow heartbeat Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on

Showing the 10 most notable of 64 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Itraconazole. Read the label on DailyMed › Where a percentage is shown, it is the share of 11,613 voluntary FDA FAERS reports for Itraconazole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Liver Extract’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Liver Extract side to compare — that is a limit of the record, not a statement that Liver Extract has no side effects.

From our Q&A

Questions About Liver Extract or Itraconazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Liver Extract or Itraconazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Itraconazole

This page covers Liver Extract only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Itraconazole page lists 182 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 136 moderate · 40 minor.

From our pharmacist’s overview on the Itraconazole page

“Serious fungal infections are what itraconazole (Sporanox, Tolsura) is for, and the drug travels through CYP3A4, the liver enzyme that also handles a large share of supplements. That overlap is why this list reaches 182 ingredients, and it earns genuine care; start with the six rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Itraconazole interaction page

One more smart check

Taking Liver Extract as Part of a Dietary Supplement Product? Check It for Interactions

We hold 595 real supplement products containing Liver Extract, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Liver Extract. Even though Liver Extract itself has no known interaction with Itraconazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Liver Extract and Itraconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Liver Extract
Top 25%

#277 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Itraconazole
Steady interest

#1,577 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Liver Extract reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Liver Extract and Itraconazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Liver Extract

What is Liver Extract?

  • Anemia and low iron
  • Vitamin B12 support
  • General energy and fatigue
  • Nutritional support for athletes
  • Liver health support

Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before purified vitamins became available, but today there is little modern evidence that it offers benefits beyond what a balanced diet or standard supplements provide. Talk with your pharmacist or doctor before using it, especially if you are pregnant, have liver disease, or have iron overload conditions.

Liver tissue, usually from cattle (beef) or pork · Capsules, tablets, powders, desiccated (dried) liver supplements, and injectable forms (prescription/historical)

An interaction check asks whether these two react with each other — it does not ask whether Liver Extract is a good idea for someone in your situation. Here is what our Liver Extract record says about it on its own.

Liver Extract: dosing

There is no official, standardized dose of liver extract, and products vary widely in how concentrated they are. Different brands also contain different amounts of vitamin A, iron, and B12.The safest approach is to follow the dose on the product label and not exceed it. They can help you decide whether you actually need it and whether a standard, purified vitamin would be a safer, more reliable choice.

From our Liver Extract monograph — the full record covers uses, side effects and every documented interaction.

Read the full Liver Extract monograph & all interactions
Medication

About Itraconazole

What Is Itraconazole Used For?

Brand names: Sporanox, Sporanox Injection, Tolsura

Itraconazole capsules (including Sporanox capsules and generic itraconazole capsules) treat serious fungal infections — blastomycosis, histoplasmosis, and aspergillosis — in both people with normal immune systems and those who are immunocompromised. Capsule forms are also approved for nail fungus (onychomycosis) caused by dermatophytes in non-immunocompromised patients. Tolsura (a gelatin-coated capsule formulation) treats blastomycosis, histoplasmosis, and aspergillosis in adults, but is not approved for nail fungus and is not interchangeable with other itraconazole products.

Itraconazole oral solution is specifically approved for oropharyngeal candidiasis (thrush — a fungal infection of the mouth) and esophageal candidiasis (a fungal infection of the food pipe). Only the oral solution has been shown to work for these mouth and throat infections; capsules cannot be substituted for this use.

Most-Reported Side Effects for Itraconazole

From FAERS, the FDA’s public side-effect reporting system (11,613 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 590 reports
Dyspnea 489 reports
Pneumonia 484 reports
Nausea 459 reports
Diarrhea 398 reports
See full Itraconazole drug information
Keep checking

Other Drugs & Liver Extract

Browse every other medication we’ve checked against Liver Extract — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
3Minor
2,826No known interaction
3 Minor 2,826 No interaction
Minor

3 interactions

No interaction 2,826 drugs checked — show the list

We also checked Liver Extract against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Liver Extract list.

See the full Liver Extract interactions page
See every supplement checked against Itraconazole, ranked by severity
Evidence & sources

Liver Extract References

The 4 references that drive our Liver Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
  3. Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
  4. Saito, H., Ebinuma, H., Tada, S., Tsunematsu, S., Atsukawa, K., Masuda, T., Tsuchiya, M., and Ishii, H. Enhancing effect of the liver extract and flavin adenin dinucleotide mixture on anti-viral efficacy of interferon in patients with chronic hepatitis C. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Liver Extract and Itraconazole Together: Common Questions

Is it safe to take Liver Extract with Itraconazole?
We do not list a known interaction between Liver Extract and Itraconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Liver Extract and Itraconazole combination checked?
Interactions in our licensed database are recorded against drug classes. Itraconazole is filed under 8 classifications, and Liver Extract has documented interactions with 2 drug classes — none of Itraconazole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Liver Extract interact with any other medications?
Yes. Liver Extract has 3 documented drug interactions in our database — Itraconazole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Itraconazole interact with any supplements?
Yes. Itraconazole has documented interactions with 182 supplements in our database — Liver Extract is not one of them. The Itraconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Liver Extract monograph Uses, safety profile, and every drug interaction in one place Itraconazole drug information The full plain-English guide to this medication Itraconazole supplement interactions Every supplement checked against Itraconazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Itraconazole and Liver Extract?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.