Maca + Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate
Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate brand name: Xywav.
We found no known interaction between Maca and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate states a food rule worth keeping to.
Maca and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate and Maca in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Maca at all — not against Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Maca safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Products Have a Food Rule — Maca Should Not Break It
At least one FDA label for a product containing Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate says to take it with food. If you take Maca on an empty stomach out of habit, keep them separate — and take Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Important Administration Information • Administer XYWAV at least 2 hours after eating ( 2.4 ).
From the Dosage and Administration section of the FDA label we read for Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate — where that label names a specific product, the instruction is that product's. See the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate
This page covers Maca only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate page lists 23 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).
By severity: 1 major · 13 moderate · 9 minor.
From our pharmacist’s overview on the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate page
“Xywav combines calcium, magnesium, potassium, and sodium oxybates to treat cataplexy and daytime sleepiness in narcolepsy, and because each nightly dose is measured and timed with real precision, this list deserves genuine attention rather than a quick skim. The one major entry, activated charcoal, can bind the drug in the gut and shar…”
Reviewed by 2 · Jul 18, 2026
Open the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate interaction page
Taking Maca as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2,489 real supplement products containing Maca, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maca. Even though Maca itself has no known interaction with Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Maca and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#68 of 1,452 supplements looked up here in the last 7 days
#124 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Maca reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Maca and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Maca
What is Maca?
- Low libido and sexual function
- Energy and stamina
- Menopause symptoms
- Mood and stress
- Fertility support
Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evidence is limited and not conclusive. It appears generally well tolerated in food amounts, but talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a hormone-related condition.
Lepidium meyenii · Brassicaceae · Root (hypocotyl) · Capsules, powder, tablets, liquid extracts, gelatinized powder
An interaction check asks whether these two react with each other — it does not ask whether Maca is a good idea for someone in your situation. Here is what our Maca record says about it on its own.
Maca: dosing
There is no official or standardized dose of maca, and the amounts used in studies have varied widely. Because of this, it is best to follow the directions on the product label.Maca is sold in different forms, including raw powder, gelatinized powder, capsules, and extracts, and the strength can differ between products. Do not assume that taking more will work better or be safer.
From our Maca monograph — the full record covers uses, side effects and every documented interaction.
About Calcium, Magnesium, Potassium, and Sodium Oxybate
What Is Calcium, Magnesium, Potassium, and Sodium Oxybate Used For?
Brand name: Xywav
Xywav (calcium, magnesium, potassium, and sodium oxybate) is approved to treat two symptoms of narcolepsy — cataplexy (sudden muscle weakness triggered by emotion) and excessive daytime sleepiness (EDS) — in patients 7 years of age and older.
Xywav is also approved to treat idiopathic hypersomnia (IH) — a sleep disorder that causes excessive sleepiness even after long periods of sleep — in adults.
Other Drugs & Maca
Browse every other medication we’ve checked against Maca — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Maca against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Methotrexate ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Maca list.
Maca References
The 1 references that drive our Maca monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Maca and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Together: Common Questions
Is it safe to take Maca with Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate?
Should I take Maca and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate at the same time of day?
Does Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.