Drug & supplement interaction

Manchurian Thorn + Phendimetrazine

Phendimetrazine brand names: Plegine, Metra, Weightrol.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Manchurian Thorn and Phendimetrazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Manchurian Thorn and Phendimetrazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phendimetrazine and Manchurian Thorn in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Manchurian Thorn safety at a glance

Manchurian Thorn overall Use caution Human safety data are limited, so use cautiously and under professional guidance.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data exist, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phendimetrazine and Manchurian Thorn? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Phendimetrazine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Phendimetrazine is filed under a single classification — oral drugs. Manchurian Thorn has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and hepatotoxic drugs (moderate) — and none of Phendimetrazine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Manchurian Thorn Does Interact With Other Medications

Manchurian Thorn has 444 moderate known drug interactions in our database — Phendimetrazine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 444 No known interaction 2,386 (incl. Phendimetrazine)
Taking anything else?

Check Another of Your Medications Against Manchurian Thorn

Covers the 2,830 medications we’ve checked against Manchurian Thorn. Pick one to open its full report.

What to actually watch for

What Phendimetrazine’s Own FDA Label Lists

This is not an interaction — none of it involves Manchurian Thorn. These are the most notable effects listed in the ADVERSE REACTIONS section of Phendimetrazine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Raised blood pressure Worth acting on
  • Tremor or shakiness
  • Flushing
  • Sweating
  • A fast or pounding heartbeat
  • Anxiety or restlessness
  • Trouble sleeping
  • Constipation
  • Stomach pain

Showing the 10 most notable of 14 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed › Manchurian Thorn’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Manchurian Thorn side to compare — that is a limit of the record, not a statement that Manchurian Thorn has no side effects.

Overlapping uses

What Phendimetrazine Is Prescribed For, and What Manchurian Thorn Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Phendimetrazine is a prescription medicine with approved uses on its FDA label. Manchurian Thorn is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Phendimetrazine is prescribed for: Phendimetrazine is used short-term — typically a few weeks — to help manage obesity in adults who have a body mass index (BMI) of 30 or higher, or 27 or higher when other risk factors like high blood pressure, diabetes, or high cholesterol are present, and who have not lost enough weight through diet and exercise alone. Phendimetrazine Tartrate extended-release capsules are specifically indicated for adults meeting those BMI criteria, including those with certain risk factors. Phendimetrazine Tartrate tablets are indicated for adults with a BMI of 30 or higher. Both forms are approved for use as a single medication only — not in combination with other weight-loss drugs or stimulants.

Manchurian Thorn has been studied for:

  • Obesity studied, not established Manchurian Thorn has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Manchurian Thorn for obesity

    Preliminary clinical research shows that taking a specific combination product (Aralox) containing Manchurian thorn 150 mg and Engelhardia roxburghiana 150 mg three times daily for 15 weeks reduces total body weight and fat when compared with placebo in obese but otherwise healthy women. It is unclear if these effects are due to Manchurian thorn, Engelhardia roxburghiana, or the combination.

    1 source cited
    1. 26972. Abidov MT, del Rio MJ, Ramazanov TZ, et al. Effects of Aralia mandshurica and Engelhardtia chrysolepis extracts on some parameters of lipid metabolism in women with nondiabetic obesity. Bull Exp Biol Med 2006;141(3):343-6. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Phendimetrazine on your own; if you are taking Manchurian Thorn for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Phendimetrazine

This page covers Manchurian Thorn only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phendimetrazine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Phendimetrazine page

“Of the 17 supplements on file for phendimetrazine, an appetite-suppressant stimulant prescribed short term for weight loss, activated charcoal is the one that demands real caution. Charcoal binds medications in the gut and can sharply cut how much of a drug your body absorbs, leaving you with less appetite control than your prescriptio…”

Reviewed by 2 · Jul 18, 2026

Open the Phendimetrazine interaction page

One more smart check

Taking Manchurian Thorn as Part of a Dietary Supplement Product? Check It for Interactions

We hold 5 real supplement products containing Manchurian Thorn, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Manchurian Thorn. Even though Manchurian Thorn itself has no known interaction with Phendimetrazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Manchurian Thorn and Phendimetrazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Manchurian Thorn
Top 25%

#363 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phendimetrazine
Steady interest

#2,241 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Manchurian Thorn reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Manchurian Thorn and Phendimetrazine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Manchurian Thorn

What is Manchurian Thorn?

  • Blood sugar support
  • Joint and arthritis discomfort
  • Fatigue and general weakness
  • Digestive complaints
  • General tonic / adaptogen-like use

Manchurian Thorn (Aralia elata) is a thorny shrub or small tree used in traditional East Asian medicine, mainly for blood sugar, joint pain, and as a general tonic. Human evidence is very limited, so its benefits are not well proven. If you are considering it, talk with your pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Aralia elata · Araliaceae · Root bark, stem bark, and sometimes young shoots · Decoctions (teas), tinctures, dried bark, capsules, and traditional food preparations of the young shoots

An interaction check asks whether these two react with each other — it does not ask whether Manchurian Thorn is a good idea for someone in your situation. Here is what our Manchurian Thorn record says about it on its own.

Manchurian Thorn: dosing

There is no well-established or standardized dose for Manchurian Thorn. Traditional preparations and modern supplement strengths vary widely, and reliable dosing studies in people are lacking.If you choose to use a product, follow the directions on the label and do not exceed the recommended amount.

From our Manchurian Thorn monograph — the full record covers uses, side effects and every documented interaction.

Read the full Manchurian Thorn monograph & all interactions
Medication

About Phendimetrazine

What Is Phendimetrazine Used For?

Brand names: Plegine, Metra, Weightrol

Phendimetrazine is used short-term — typically a few weeks — to help manage obesity in adults who have a body mass index (BMI) of 30 or higher, or 27 or higher when other risk factors like high blood pressure, diabetes, or high cholesterol are present, and who have not lost enough weight through diet and exercise alone.

Phendimetrazine Tartrate extended-release capsules are specifically indicated for adults meeting those BMI criteria, including those with certain risk factors. Phendimetrazine Tartrate tablets are indicated for adults with a BMI of 30 or higher. Both forms are approved for use as a single medication only — not in combination with other weight-loss drugs or stimulants.

See full Phendimetrazine drug information
Keep checking

Other Drugs & Manchurian Thorn

Browse every other medication we’ve checked against Manchurian Thorn — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
444Moderate
0Minor
2,385No known interaction
444 Moderate 2,385 No interaction
Moderate

444 interactions

Showing 60 of 444 moderate interactions — see all 444 on the Manchurian Thorn page.

No interaction 2,385 drugs checked — show the list

We also checked Manchurian Thorn against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,385 medications checked with no known interaction — see the full Manchurian Thorn list.

See the full Manchurian Thorn interactions page
See every supplement checked against Phendimetrazine, ranked by severity
Evidence & sources

Manchurian Thorn References

The 4 references that drive our Manchurian Thorn monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Abidov MT, del Rio MJ, Ramazanov TZ, et al. Effects of Aralia mandshurica and Engelhardtia chrysolepis extracts on some parameters of lipid metabolism in women with nondiabetic obesity. Bull Exp Biol Med 2006;141(3):343-6. PubMed
  2. Burgos R, Hancke J, Caceres DD, et al. Hepatotoxic effect of Aralia mandshurica dried root extract in pigs. Phytotherapy Res 1997;11(1):59-61. DOI
  3. Burgos R, Hancke J, Wikman G, et al. Toxicological assessment of Aralia mandshurica (Araliaceae) root extract after subchronic administration in rats. A biochemical and histological study. Phytotherapy Res 1994;8(1):1-9.
  4. Martinez, B. and Staba, E. J. The physiological effects of Aralia, Panax and Eleutherococcus on exercised rats. Jpn J Pharmacol 1984;35(2):79-85. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Manchurian Thorn and Phendimetrazine Together: Common Questions

Is it safe to take Manchurian Thorn with Phendimetrazine?
We do not list a known interaction between Manchurian Thorn and Phendimetrazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Manchurian Thorn and Phendimetrazine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Manchurian Thorn in each. That is a conversation for your prescriber, especially if Phendimetrazine is being adjusted to a target.
How was the Manchurian Thorn and Phendimetrazine combination checked?
Interactions in our licensed database are recorded against drug classes. Phendimetrazine is filed under 1 classification, and Manchurian Thorn has documented interactions with 2 drug classes — none of Phendimetrazine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Manchurian Thorn interact with any other medications?
Yes. Manchurian Thorn has 444 documented drug interactions in our database — Phendimetrazine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Phendimetrazine interact with any supplements?
Yes. Phendimetrazine has documented interactions with 17 supplements in our database — Manchurian Thorn is not one of them. The Phendimetrazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Manchurian Thorn monograph Uses, safety profile, and every drug interaction in one place Phendimetrazine drug information The full plain-English guide to this medication Phendimetrazine supplement interactions Every supplement checked against Phendimetrazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phendimetrazine and Manchurian Thorn?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.