Drug & supplement interaction

Maritime Pine + Cyproheptadine

Cyproheptadine brand name: Periactin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Maritime Pine and Cyproheptadine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Maritime Pine and Cyproheptadine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cyproheptadine and Maritime Pine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Maritime Pine safety at a glance

Maritime Pine overall Use caution Generally well tolerated in studies, but long-term safety is not fully established.
Pregnancy Possibly Safe When used orally during the third trimester of pregnancy. In one small clinical study, a standardized extract of maritime pine bark (Pycnogenol, Horphag Researc... Read the full pregnancy detail
Breastfeeding Avoid Not enough safety data, so it is best avoided while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cyproheptadine and Maritime Pine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cyproheptadine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cyproheptadine is filed under 4 classifications — including anticholinergic drugs, photosensitizing drugs, seizure threshold lowering drugs. Maritime Pine has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Cyproheptadine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Maritime Pine Does Interact With Other Medications

Maritime Pine has 327 moderate known drug interactions in our database — Cyproheptadine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 327 No known interaction 2,503 (incl. Cyproheptadine)
Taking anything else?

Check Another of Your Medications Against Maritime Pine

Covers the 2,830 medications we’ve checked against Maritime Pine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Maritime Pine and Cyproheptadine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Dizziness Additional detail

    Maritime Pine

    “Orally, a standardized extract of maritime pine bark (Pycnogenol, Horphag Research) may cause dizziness and severe vertigo. Also, headache has been reported in a single trial.”

    Maritime Pine · Natural Medicines adverse-effect record, reported in cluster headache.

    5 sources cited
    1. 15521. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
    2. 15522. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
    3. 17300. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
    4. 50904. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
    5. 50933. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.

    Cyproheptadine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cyproheptadine. Read the label on DailyMed ›

  • Headache Additional detail

    Maritime Pine

    Recorded for Maritime Pine in the same Natural Medicines adverse-effect record shown under Dizziness above.

    Cyproheptadine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cyproheptadine. Read the label on DailyMed ›

Reported for Maritime Pine but not commonly for Cyproheptadine: a heart attack, heart failure and chest pain.

Effects for Cyproheptadine come from the ADVERSE REACTIONS section of its FDA label; effects for Maritime Pine come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Maritime Pine in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally during the third trimester of pregnancy. In one small clinical study, a standardized extract of maritime pine bark (Pycnogenol, Horphag Research) has been used at a dose of 30 mg daily with apparent safety during the third trimester of pregnancy. However, more evidence is needed; use cautiously or avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Cyproheptadine

This page covers Maritime Pine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cyproheptadine page lists 72 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Alfalfa (moderate) and Angel's Trumpet (moderate).

By severity: 3 major · 57 moderate · 12 minor.

From our pharmacist’s overview on the Cyproheptadine page

“Cyproheptadine (Periactin) is an older antihistamine that dries you out and slows you down on its own, which is exactly why its supplement list warrants genuine care rather than a quick skim. Of the 72 ingredients on file, three carry a major rating.”

Reviewed by 2 · Jul 18, 2026

Open the Cyproheptadine interaction page

One more smart check

Taking Maritime Pine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 452 real supplement products containing Maritime Pine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Maritime Pine. Even though Maritime Pine itself has no known interaction with Cyproheptadine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Maritime Pine and Cyproheptadine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Maritime Pine
Top 25%

#315 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cyproheptadine
Top 25%

#511 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Maritime Pine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Maritime Pine and Cyproheptadine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Maritime Pine

What is Maritime Pine?

Maritime Pine
  • Circulation and vein health
  • Antioxidant support
  • Skin health and aging
  • High blood pressure
  • Joint comfort

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small or industry-funded, so benefits are not firmly proven. It is generally well tolerated, but talk to your pharmacist or doctor before starting it.

Pinus pinaster · Pinaceae · Bark (extract) · Capsules, tablets, creams, and topical gels

An interaction check asks whether these two react with each other — it does not ask whether Maritime Pine is a good idea for someone in your situation. Here is what our Maritime Pine record says about it on its own.

Maritime Pine: dosing

There is no single official dose of maritime pine bark extract. Doses used in studies have varied depending on the product and the condition being studied, and most research has used standardized branded extracts.Because strength and quality differ between brands, follow the directions on the product label and do not exceed the recommended amount.

From our Maritime Pine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Maritime Pine monograph & all interactions
Medication

About Cyproheptadine

What Is Cyproheptadine Used For?

Brand name: Periactin

Cyproheptadine treats a range of allergic conditions, including perennial and seasonal allergic rhinitis (year-round or seasonal nasal allergies), vasomotor rhinitis (non-allergic nasal symptoms), and allergic conjunctivitis (itchy, watery eyes caused by allergens or foods). It also helps with allergic skin reactions such as urticaria (hives) and angioedema (skin swelling).

Additional uses include cold urticaria (hives triggered by cold), dermatographism (skin that hives when scratched), and helping to calm allergic reactions to blood or plasma transfusions. It is also used as a supportive therapy alongside epinephrine after a severe allergic reaction (anaphylaxis) has been initially controlled.

See full Cyproheptadine drug information
Keep checking

Other Drugs & Maritime Pine

Browse every other medication we’ve checked against Maritime Pine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
327Moderate
0Minor
2,502No known interaction
327 Moderate 2,502 No interaction
Moderate

327 interactions

Showing 60 of 327 moderate interactions — see all 327 on the Maritime Pine page.

No interaction 2,502 drugs checked — show the list

We also checked Maritime Pine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,502 medications checked with no known interaction — see the full Maritime Pine list.

See the full Maritime Pine interactions page
See every supplement checked against Cyproheptadine, ranked by severity
Evidence & sources

Maritime Pine References

The 14 references that drive our Maritime Pine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  2. Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
  3. Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
  4. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
  5. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
  6. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
  7. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
  8. Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
  9. Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
  10. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
  11. Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
  12. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
  13. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
  14. Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Maritime Pine and Cyproheptadine Together: Common Questions

Is it safe to take Maritime Pine with Cyproheptadine?
We do not list a known interaction between Maritime Pine and Cyproheptadine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Maritime Pine and Cyproheptadine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Maritime Pine and Cyproheptadine combination checked?
Interactions in our licensed database are recorded against drug classes. Cyproheptadine is filed under 4 classifications, and Maritime Pine has documented interactions with 3 drug classes — none of Cyproheptadine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Maritime Pine interact with any other medications?
Yes. Maritime Pine has 327 documented drug interactions in our database — Cyproheptadine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cyproheptadine interact with any supplements?
Yes. Cyproheptadine has documented interactions with 72 supplements in our database — Maritime Pine is not one of them. The Cyproheptadine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Maritime Pine monograph Uses, safety profile, and every drug interaction in one place Cyproheptadine drug information The full plain-English guide to this medication Cyproheptadine supplement interactions Every supplement checked against Cyproheptadine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cyproheptadine and Maritime Pine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.