Drug & supplement interaction

Mediterranean Diet + Thiotepa

Thiotepa brand names: Thioplex, Tepadina.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Mediterranean Diet and Thiotepa in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Mediterranean Diet and Thiotepa

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Thiotepa and Mediterranean Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Mediterranean Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Mediterranean Diet at all — not against Thiotepa, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Mediterranean Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mediterranean Diet safety at a glance

Mediterranean Diet overall Generally safe It is a balanced, whole-food eating pattern considered safe and healthy for most people.
Pregnancy Possibly Safe When the Mediterranean diet is used appropriately during pregnancy. However, the red wine component of the Mediterranean diet should be avoided in pregnancy. Read the full pregnancy detail
Breastfeeding Generally safe A balanced Mediterranean-style diet is generally appropriate while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Thiotepa and Mediterranean Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Thiotepa’s Own FDA Label Lists

This is not an interaction — none of it involves Mediterranean Diet. These are the most notable effects listed in the ADVERSE REACTIONS section of Thiotepa’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you follow Mediterranean Diet and take the medicine. 10 of them are worth acting on rather than waiting out — marked below.

  • Loss of vision Worth acting on
  • Thoughts of self-harm Worth acting on
  • Hearing loss Worth acting on
  • A stroke or mini-stroke Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Memory problems Worth acting on
  • Trouble swallowing Worth acting on
  • Trouble passing urine Worth acting on
  • Low sodium Worth acting on
  • Unsteadiness Worth acting on

Showing the 10 most notable of 48 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Thiotepa. Read the label on DailyMed › Mediterranean Diet’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Mediterranean Diet side to compare — that is a limit of the record, not a statement that Mediterranean Diet has no side effects.

Special populations

Mediterranean Diet in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When the Mediterranean diet is used appropriately during pregnancy. However, the red wine component of the Mediterranean diet should be avoided in pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Thiotepa

This page covers Mediterranean Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Thiotepa page lists 146 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Acerola (moderate).

By severity: 3 major · 102 moderate · 41 minor.

From our pharmacist’s overview on the Thiotepa page

“Thiotepa (Thioplex, Tepadina) is chemotherapy, given for several cancers and to prepare patients for stem cell transplant, so its 146 supplement interactions make up a list to respect rather than skim. Three carry a major rating: grapefruit, St.”

Reviewed by 2 · Jul 18, 2026

Open the Thiotepa interaction page

How much people look this up

Where Mediterranean Diet and Thiotepa Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mediterranean Diet
Steady interest

#1,156 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Thiotepa
Steady interest

#2,247 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mediterranean Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Mediterranean Diet and Thiotepa records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Mediterranean Diet

What is Mediterranean Diet?

  • Heart health
  • Weight management
  • Type 2 diabetes prevention
  • Brain and memory health
  • Reducing inflammation
  • General longevity

The Mediterranean diet is an eating pattern rich in vegetables, fruits, whole grains, legumes, nuts, fish, and olive oil, with limited red meat and processed foods. It has some of the strongest evidence of any diet for supporting heart health and is widely considered safe for most people. Talk to your doctor or a dietitian before making big changes, especially if you have a medical condition.

Whole-food eating pattern (not a pill or supplement)

An interaction check asks whether these two react with each other — it does not ask whether Mediterranean Diet is a good idea for someone in your situation. Here is what our Mediterranean Diet record says about it on its own.

Mediterranean Diet: dosing

There is no pill or fixed "dose" for the Mediterranean diet—it is an overall pattern. The general approach is to make vegetables, fruits, whole grains, beans, and olive oil the base of most meals, eat fish a couple of times per week, choose nuts and seeds for snacks, and limit red meat, processed foods, and sweets.A registered dietitian can help you tailor the pattern to your calorie needs, health conditions, and food preferences.

From our Mediterranean Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mediterranean Diet monograph & all interactions
Medication

About Thiotepa Injection

What Is Thiotepa Injection Used For?

Brand names: Thioplex, Tepadina

Tepadina (thiotepa) injection is used for several purposes. It treats adenocarcinoma (a type of cancer) of the breast or ovary. It is also used to control malignant effusions — abnormal fluid buildup in body cavities caused by cancer spreading to those areas. For bladder cancer, Tepadina treats superficial papillary carcinoma of the urinary bladder.

Tepadina is also used in pediatric patients with class 3 beta-thalassemia (a severe inherited blood disorder). In those patients, it is given as part of a preparative regimen — a conditioning treatment to reduce the risk of graft rejection before an allogeneic stem cell transplant (a transplant using donor stem cells), alongside the chemotherapy drugs busulfan and cyclophosphamide.

Most-Reported Side Effects for Thiotepa

From FAERS, the FDA’s public side-effect reporting system (9,494 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Febrile neutropenia 814 reports
Mucosal inflammation 807 reports
Cytomegalovirus infection 533 reports
Fever 516 reports
Acute graft versus host disease 458 reports
See full Thiotepa Injection drug information
Keep checking

Other Drugs & Mediterranean Diet

Browse every other medication we’ve checked against Mediterranean Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Mediterranean Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mediterranean Diet list.

See the full Mediterranean Diet interactions page
See every supplement checked against Thiotepa, ranked by severity
Evidence & sources

Mediterranean Diet References

The 6 references that drive our Mediterranean Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Assaf-Balut C, García de la Torre N, Fuentes M, et al. A high adherence to six food targets of the Mediterranean diet in the late first trimester is associated with a reduction in the risk of materno-foetal outcomes: The St. Carlos gestational diabetes me
  2. Assaf-Balut C, García de la Torre N, Durán A, et al. A Mediterranean diet with additional extra virgin olive oil and pistachios reduces the incidence of gestational diabetes mellitus (GDM): A randomized controlled trial: The St. Carlos GDM prevention stud
  3. De Giuseppe R, Bocchi M, Maffoni S, et al. Mediterranean Diet and Lifestyle Habits during Pregnancy: Is There an Association with Small for Gestational Age Infants? An Italian Single Centre Experience. Nutrients 2021;13(6):1941. PubMed
  4. Crovetto F, Crispi F, Casas R, et al. Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction on Prevention of Small-for-Gestational Age Birth Weights in Newborns Born to At-Risk Pregnant Individuals: The IMPACT BCN Randomized Clinical Trial. DOI
  5. Makarem N, Chau K, Miller EC, et al. Association of a Mediterranean Diet pattern with adverse pregnancy outcomes among US women. JAMA Netw Open 2022;5(12):e2248165. PubMed
  6. Yang J, Song Y, Gaskins AJ, et al. Mediterranean diet and female reproductive health over lifespan: a systematic review and meta-analysis. Am J Obstet Gynecol 2023;229(6):617-631. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Mediterranean Diet While Taking Thiotepa: Common Questions

Is it safe to follow Mediterranean Diet while taking Thiotepa?
We do not list a known interaction between Mediterranean Diet and Thiotepa. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Thiotepa interact with any supplements?
Yes. Thiotepa has documented interactions with 146 supplements in our database — Mediterranean Diet is not one of them. The Thiotepa interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mediterranean Diet monograph Uses, safety profile, and every drug interaction in one place Thiotepa Injection drug information The full plain-English guide to this medication Thiotepa supplement interactions Every supplement checked against Thiotepa, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Thiotepa and Mediterranean Diet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.