Medication interaction hub

What Supplements Interact with Thiotepa?

Thiotepa brand names: Thioplex, Tepadina. Every interaction below applies to the brands too.

146 Interactions 3 Major 102 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Thiotepa? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Thiotepa against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Thiotepa (Thioplex, Tepadina) is chemotherapy, given for several cancers and to prepare patients for stem cell transplant, so its 146 supplement interactions make up a list to respect rather than skim. Three carry a major rating: grapefruit, St. John's wort, and activated charcoal. The first two act on CYP3A4, the liver enzyme behind most of this list, and can push thiotepa's levels up or drive them down, either of which matters with a chemotherapy drug. Activated charcoal can pull the medication out of the body before it has done its work.

Most of the remaining entries, 102 rated moderate and 41 minor, echo that same enzyme story more softly, or are fibers and charcoals best spaced well apart from any medicine taken by mouth. A smaller group of antioxidant supplements might blunt the chemotherapy itself, and that question belongs with the oncology team, not a guess at home.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 102 Minor 41 No known interaction 1,306

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Thiotepa: Top Interactions at a Glance

The Thiotepa supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 146 interacting ingredients — plus 1,306 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Thiotepa Combinations Today

The Thiotepa + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Coenzyme Q10 + Thiotepai

Coenzyme Q10 has antioxidant effects.

Read the full interaction Moderate Likelihood Possible African Wild Potato + Thiotepai

In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.

Read the full interaction Moderate Likelihood Possible Ginkgo + Thiotepai

Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible False Unicorn + Thiotepai

In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Read the full interaction Moderate Likelihood Possible Kratom + Thiotepai

Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Milk Thistle + Thiotepai

Theoretically, milk thistle might inhibit CYP2B6.

Read the full interaction
The complete list

Every Supplement Checked Against Thiotepa

All 1,452 ingredients in our database, ranked by severity — 146 with a Thiotepa interaction on file and 1,306 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Thiotepa?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coenzyme Q10 with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coenzyme Q10 has antioxidant effects.

Full Coenzyme Q10 + Thiotepa answer

Can you take African Wild Potato with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.

Full African Wild Potato + Thiotepa answer

Can you take Ginkgo with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Thiotepa answer

Can you take False Unicorn with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Thiotepa answer

Can you take Kratom with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Kratom + Thiotepa answer

Can you take Dhea with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Thiotepa answer

Can you take Diosmin with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Thiotepa answer

Can you take Echinacea with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Thiotepa answer

Can you take Eucalyptus with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Thiotepa answer

Can you take European Barberry with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Thiotepa answer

Can you take Evodia with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Thiotepa answer

Can you take Fennel with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Thiotepa answer

Can you take Feverfew with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Thiotepa answer

Can you take Fo-ti with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Fo-ti + Thiotepa answer

Can you take Garlic with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Thiotepa answer

Can you take German Chamomile with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Thiotepa answer

Can you take Ginger with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Thiotepa answer

Can you take Goji with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Thiotepa answer

Can you take Goldenseal with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Thiotepa answer

Can you take Goldthread with Thiotepa?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Thiotepa answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Thiotepa is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Thiotepa, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Thiotepa sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Thiotepa through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Thiotepa through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Thiotepa through this category.

Alkylating Agents 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Thiotepa through this category.

Antineoplastics 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Thiotepa through this category.

About Thiotepa

Thiotepa injection is a chemotherapy drug used to treat certain cancers, control fluid buildup caused by cancer, and prepare the body for stem cell transplantation.

Generic name: Thiotepa  ·  Brand names: Thioplex, Tepadina.

See the full Thiotepa Injection drug information

Related: does Thiotepa deplete any nutrients?

Thiotepa has 2 reported nutrient associations in the research literature — see the Thiotepa nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Thiotepa

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Thiotepa.

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Pharmacist Counseling Corner

Thiotepa & Supplements: Common Questions

What supplements interact with Thiotepa?
More than you might expect — 146 in total, though they are far from equal: 3 are rated major, 102 moderate, and 41 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Thiotepa supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Thiotepa?
Usually yes — most people on Thiotepa can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Thioplex have the same supplement interactions as Thiotepa?
Yes — Thioplex, Tepadina all contain Thiotepa, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Thiotepa deplete any vitamins or nutrients?
It might — Thiotepa has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Thiotepa nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Thiotepa and my other medications?
This page covers Thiotepa against supplements and herbal ingredients. Checking Thiotepa against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Thiotepa Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.