Medication interaction hub

What Supplements Interact with Busulfan?

Busulfan brand names: Myleran, Busulfex. Every interaction below applies to the brands too.

148 Interactions 3 Major 104 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Busulfan? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Busulfan against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

148 supplements and herbal ingredients have interactions with Busulfan on file in the HelloPharmacist interaction database — 3 rated major, 104 moderate, and 41 minor. The most serious involve Grapefruit, Activated Charcoal and St. John's Wort.

Our assessment: with 3 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Busulfan.

Major 3 Moderate 104 Minor 41 No known interaction 1,304

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Busulfan: Top Interactions at a Glance

The Busulfan supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 148 interacting ingredients — plus 1,304 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Busulfan Combinations Today

The Busulfan + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Vitamin C + Busulfani

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Read the full interaction Moderate Likelihood Possible Coenzyme Q10 + Busulfani

Coenzyme Q10 has antioxidant effects.

Read the full interaction Moderate Likelihood Possible Acerola + Busulfani

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full interaction Major Likelihood Likely Grapefruit + Busulfani

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Unlikely Jequirity + Busulfani

In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Read the full interaction Minor Likelihood Unlikely American Pawpaw + Busulfani

American pawpaw (Asimina triloba) contains Annonacin, a natural compound that has been investigated for its potential anticancer effects.

Read the full interaction
The complete list

Every Supplement Checked Against Busulfan

All 1,452 ingredients in our database, ranked by severity — 148 with a Busulfan interaction on file and 1,304 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Busulfan?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Busulfan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Full Vitamin C + Busulfan answer

Can you take Coenzyme Q10 with Busulfan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coenzyme Q10 has antioxidant effects.

Full Coenzyme Q10 + Busulfan answer

Can you take Acerola with Busulfan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Full Acerola + Busulfan answer

Can you take Grapefruit with Busulfan?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Busulfan answer

Can you take Jequirity with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Busulfan answer

Can you take Vitamin E with Busulfan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Busulfan answer

Can you take White Pepper with Busulfan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Busulfan answer

Can you take Wild Cherry with Busulfan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Busulfan answer

Can you take Zedoary with Busulfan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Busulfan answer

Can you take Thyroid Extract with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Busulfan answer

Can you take Aegeline with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Busulfan answer

Can you take Agar with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Busulfan answer

Can you take Algin with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Busulfan answer

Can you take Ashwagandha with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Busulfan answer

Can you take Atractylodes with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might increase the levels of CYP3A4 substrates.

Full Atractylodes + Busulfan answer

Can you take Bael with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael and its constituents marmelosin and marmesinin inhibited cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Bael + Busulfan answer

Can you take Black Psyllium with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Busulfan answer

Can you take Blond Psyllium with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Busulfan answer

Can you take Breadfruit with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, breadfruit might inhibit cytochrome P450 3A4 (CYP3A4) and increase levels of drugs metabolized by these enzymes; until more i...

Full Breadfruit + Busulfan answer

Can you take Carob with Busulfan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Busulfan answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Busulfan is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Busulfan, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Busulfan sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Busulfan through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Busulfan through this category.

Alkylating Agents 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Busulfan through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Busulfan through this category.

Antineoplastics 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Busulfan through this category.

About Busulfan

Busulfan is a chemotherapy drug used to treat chronic myelogenous leukemia (CML), available as tablets for palliative treatment and as an injection used before stem cell transplantation.

Generic name: Busulfan  ·  Brand names: Myleran, Busulfex.

See the full Busulfan drug information

Related: does Busulfan deplete any nutrients?

Busulfan has 2 reported nutrient associations in the research literature — see the Busulfan nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Busulfan

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Busulfan.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Busulfan & Supplements: Common Questions

What supplements interact with Busulfan?
More than you might expect — 148 in total, though they are far from equal: 3 are rated major, 104 moderate, and 41 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Busulfan supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Busulfan?
Usually yes — most people on Busulfan can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Myleran have the same supplement interactions as Busulfan?
Yes — Myleran, Busulfex all contain Busulfan, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Busulfan deplete any vitamins or nutrients?
It might — Busulfan has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Busulfan nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Busulfan and my other medications?
This page covers Busulfan against supplements and herbal ingredients. Checking Busulfan against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Busulfan drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.