Drug & supplement interaction

Mediterranean Diet + Tadalafil

Tadalafil brand names: Cialis, Tadliq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Mediterranean Diet and Tadalafil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Mediterranean Diet and Tadalafil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tadalafil and Mediterranean Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Mediterranean Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Mediterranean Diet at all — not against Tadalafil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Mediterranean Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mediterranean Diet safety at a glance

Mediterranean Diet overall Generally safe It is a balanced, whole-food eating pattern considered safe and healthy for most people.
Pregnancy Possibly Safe When the Mediterranean diet is used appropriately during pregnancy. However, the red wine component of the Mediterranean diet should be avoided in pregnancy. Read the full pregnancy detail
Breastfeeding Generally safe A balanced Mediterranean-style diet is generally appropriate while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tadalafil and Mediterranean Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Tadalafil’s Own FDA Label Lists

This is not an interaction — none of it involves Mediterranean Diet. These are the most notable effects listed in the ADVERSE REACTIONS section of Tadalafil’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you follow Mediterranean Diet and take the medicine.

  • Flushing
  • A stuffy or runny nose
  • Back pain
  • Muscle pain
  • Stomach upset
  • Headache mentioned in 11.1% of FDA reports for Tadalafil
  • Stomach pain

From the ADVERSE REACTIONS section of the FDA label for Tadalafil. Read the label on DailyMed › Where a percentage is shown, it is the share of 98,103 voluntary FDA FAERS reports for Tadalafil that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Mediterranean Diet’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Mediterranean Diet side to compare — that is a limit of the record, not a statement that Mediterranean Diet has no side effects.

Special populations

Mediterranean Diet in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When the Mediterranean diet is used appropriately during pregnancy. However, the red wine component of the Mediterranean diet should be avoided in pregnancy.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Mediterranean Diet or Tadalafil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Mediterranean Diet or Tadalafil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tadalafil

This page covers Mediterranean Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tadalafil page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Grapefruit (major), Hawthorn (major) and St. John's Wort (major).

By severity: 5 major · 98 moderate · 41 minor.

From our pharmacist’s overview on the Tadalafil page

“Grapefruit juice is the first thing to know about if you take tadalafil (Cialis, Tadliq). It blocks CYP3A4, the enzyme that clears the drug, so blood levels climb and side effects like a steep drop in blood pressure become more likely.”

Reviewed by 2 · Jul 18, 2026

Open the Tadalafil interaction page

How much people look this up

Where Mediterranean Diet and Tadalafil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mediterranean Diet
Steady interest

#947 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tadalafil
Top 1%

#16 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mediterranean Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Mediterranean Diet and Tadalafil records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Mediterranean Diet

What is Mediterranean Diet?

  • Heart health
  • Weight management
  • Type 2 diabetes prevention
  • Brain and memory health
  • Reducing inflammation
  • General longevity

The Mediterranean diet is an eating pattern rich in vegetables, fruits, whole grains, legumes, nuts, fish, and olive oil, with limited red meat and processed foods. It has some of the strongest evidence of any diet for supporting heart health and is widely considered safe for most people. Talk to your doctor or a dietitian before making big changes, especially if you have a medical condition.

Whole-food eating pattern (not a pill or supplement)

An interaction check asks whether these two react with each other — it does not ask whether Mediterranean Diet is a good idea for someone in your situation. Here is what our Mediterranean Diet record says about it on its own.

Mediterranean Diet: dosing

There is no pill or fixed "dose" for the Mediterranean diet—it is an overall pattern. The general approach is to make vegetables, fruits, whole grains, beans, and olive oil the base of most meals, eat fish a couple of times per week, choose nuts and seeds for snacks, and limit red meat, processed foods, and sweets.A registered dietitian can help you tailor the pattern to your calorie needs, health conditions, and food preferences.

From our Mediterranean Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mediterranean Diet monograph & all interactions
Medication

About Tadalafil

What Is Tadalafil Used For?

Brand names: Cialis, Tadliq

Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks.

Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.

Most-Reported Side Effects for Tadalafil

From FAERS, the FDA’s public side-effect reporting system (99,210 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 11,917 reports
Headache 10,982 reports
Diarrhea 8,020 reports
Nausea 6,697 reports
Fatigue 6,080 reports
See full Tadalafil drug information
Keep checking

Other Drugs & Mediterranean Diet

Browse every other medication we’ve checked against Mediterranean Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Mediterranean Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mediterranean Diet list.

See the full Mediterranean Diet interactions page
See every supplement checked against Tadalafil, ranked by severity
Evidence & sources

Mediterranean Diet References

The 6 references that drive our Mediterranean Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Assaf-Balut C, García de la Torre N, Fuentes M, et al. A high adherence to six food targets of the Mediterranean diet in the late first trimester is associated with a reduction in the risk of materno-foetal outcomes: The St. Carlos gestational diabetes me
  2. Assaf-Balut C, García de la Torre N, Durán A, et al. A Mediterranean diet with additional extra virgin olive oil and pistachios reduces the incidence of gestational diabetes mellitus (GDM): A randomized controlled trial: The St. Carlos GDM prevention stud
  3. De Giuseppe R, Bocchi M, Maffoni S, et al. Mediterranean Diet and Lifestyle Habits during Pregnancy: Is There an Association with Small for Gestational Age Infants? An Italian Single Centre Experience. Nutrients 2021;13(6):1941. PubMed
  4. Crovetto F, Crispi F, Casas R, et al. Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction on Prevention of Small-for-Gestational Age Birth Weights in Newborns Born to At-Risk Pregnant Individuals: The IMPACT BCN Randomized Clinical Trial. DOI
  5. Makarem N, Chau K, Miller EC, et al. Association of a Mediterranean Diet pattern with adverse pregnancy outcomes among US women. JAMA Netw Open 2022;5(12):e2248165. PubMed
  6. Yang J, Song Y, Gaskins AJ, et al. Mediterranean diet and female reproductive health over lifespan: a systematic review and meta-analysis. Am J Obstet Gynecol 2023;229(6):617-631. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Mediterranean Diet While Taking Tadalafil: Common Questions

Is it safe to follow Mediterranean Diet while taking Tadalafil?
We do not list a known interaction between Mediterranean Diet and Tadalafil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Tadalafil interact with any supplements?
Yes. Tadalafil has documented interactions with 144 supplements in our database — Mediterranean Diet is not one of them. The Tadalafil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mediterranean Diet monograph Uses, safety profile, and every drug interaction in one place Tadalafil drug information The full plain-English guide to this medication Tadalafil supplement interactions Every supplement checked against Tadalafil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tadalafil and Mediterranean Diet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.