Drug & supplement interaction

Methylsulfonylmethane (msm) + Aspirin, Codeine Phosphate, Phenobarbital

Aspirin, Codeine Phosphate, Phenobarbital brand name: Phenaphen.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Methylsulfonylmethane (msm) and Aspirin, Codeine Phosphate, Phenobarbital in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Methylsulfonylmethane (msm) and Aspirin, Codeine Phosphate, Phenobarbital

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Aspirin, Codeine Phosphate, Phenobarbital and Methylsulfonylmethane (msm) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Methylsulfonylmethane (msm) at all — not against Aspirin, Codeine Phosphate, Phenobarbital, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Methylsulfonylmethane (msm) safety at a glance

Methylsulfonylmeth... overall Use caution Generally well tolerated short-term, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety information for breastfeeding, so avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Aspirin, Codeine Phosphate, Phenobarbital and Methylsulfonylmethane (msm)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Methylsulfonylmethane (msm) Itself Has Been Linked To

This is not an interaction — nothing below involves Aspirin, Codeine Phosphate, Phenobarbital. It is the side-effect record for Methylsulfonylmethane (msm) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Methylsulfonylmethane (msm), this list is the first place to look.

  • Trouble concentrating / Trouble sleeping / Tiredness / Headache Additional detail

    “Orally, MSM may cause headache, fatigue, insomnia, and difficulty concentrating.”

    Methylsulfonylmethane (msm) · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 8574. Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-73. PubMed
    2. 14335. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94. PubMed
  • Bloating or gas / Stomach upset / Diarrhea / Nausea Additional detail

    “Orally, MSM may cause mild gastrointestinal discomfort, nausea, bloating, and diarrhea.”

    Methylsulfonylmethane (msm) · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 8574. Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-73. PubMed
    2. 12469. Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63. PubMed
  • Itching Additional detail

    “In rare cases, MSM has caused pruritus when taken orally.”

    Methylsulfonylmethane (msm) · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 8574. Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-73. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Methylsulfonylmethane (msm) — expand a row for the licensed statement it rests on. We haven’t matched Aspirin, Codeine Phosphate, Phenobarbital to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Aspirin, Codeine Phosphate, Phenobarbital.

Everything else you take

See Every Supplement That Interacts With Aspirin, Codeine Phosphate, Phenobarbital

This page covers Methylsulfonylmethane (msm) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Codeine Phosphate, Phenobarbital page lists 352 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 12 major · 304 moderate · 36 minor.

From our pharmacist’s overview on the Aspirin, Codeine Phosphate, Phenobarbital page

“Alcohol is the entry I would flag first with Phenaphen (aspirin, codeine phosphate, phenobarbital): beer or wine layered onto codeine and phenobarbital can deepen sedation and, at worst, slow breathing. This medication deserves real caution with supplements.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Codeine Phosphate, Phenobarbital interaction page

How much people look this up

Where Methylsulfonylmethane (msm) and Aspirin, Codeine Phosphate, Phenobarbital Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Methylsulfonylmethane (msm)
Top half

#665 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Codeine Phosphate, Phenobarbital
Top 10%

#252 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Methylsulfonylmethane (msm) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Methylsulfonylmethane (msm) and Aspirin, Codeine Phosphate, Phenobarbital records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Methylsulfonylmethane (msm)

What is Methylsulfonylmethane (msm)?

  • Osteoarthritis and joint pain
  • Muscle soreness after exercise
  • Inflammation
  • Skin and hair health
  • Allergy symptoms

Methylsulfonylmethane (MSM) is a natural sulfur compound that people most often take for joint pain and exercise recovery. Some early research suggests it may modestly help osteoarthritis symptoms, but the evidence is limited and more study is needed. It appears generally well tolerated in the short term, but talk with your pharmacist or doctor before starting it.

Not applicable (a sulfur-containing compound) · Capsules, tablets, powders, creams, and combination joint supplements

An interaction check asks whether these two react with each other — it does not ask whether Methylsulfonylmethane (msm) is a good idea for someone in your situation. Here is what our Methylsulfonylmethane (msm) record says about it on its own.

Methylsulfonylmethane (msm): dosing

There is no official or standardized dose of MSM. Studies have used a wide range of amounts, and the best dose is not clearly established.The safest approach is to follow the directions on the product label and not take more than recommended. They can help you decide if it is appropriate and what amount is reasonable.

From our Methylsulfonylmethane (msm) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Methylsulfonylmethane (msm) monograph & all interactions
Keep checking

Other Drugs & Methylsulfonylmethane (msm)

Browse every other medication we’ve checked against Methylsulfonylmethane (msm) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Methylsulfonylmethane (msm) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Methylsulfonylmethane (msm) list.

See the full Methylsulfonylmethane (msm) interactions page
See every supplement checked against Aspirin, Codeine Phosphate, Phenobarbital, ranked by severity
Evidence & sources

Methylsulfonylmethane (msm) References

The 4 references that drive our Methylsulfonylmethane (msm) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-73. PubMed
  2. Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63. PubMed
  3. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94. PubMed
  4. Hwang JC, Khine KT, Lee JC, Boyer DS, Francis BA. Methyl-sulfonyl-methane (MSM)-induced acute angle closure. J Glaucoma. 2015 Apr-May;24(4):e28-30. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Methylsulfonylmethane (msm) and Aspirin, Codeine Phosphate, Phenobarbital Together: Common Questions

Is it safe to take Methylsulfonylmethane (msm) with Aspirin, Codeine Phosphate, Phenobarbital?
We do not list a known interaction between Methylsulfonylmethane (msm) and Aspirin, Codeine Phosphate, Phenobarbital. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Aspirin, Codeine Phosphate, Phenobarbital interact with any supplements?
Yes. Aspirin, Codeine Phosphate, Phenobarbital has documented interactions with 352 supplements in our database — Methylsulfonylmethane (msm) is not one of them. The Aspirin, Codeine Phosphate, Phenobarbital interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Methylsulfonylmethane (msm) monograph Uses, safety profile, and every drug interaction in one place Aspirin, Codeine Phosphate, Phenobarbital supplement interactions Every supplement checked against Aspirin, Codeine Phosphate, Phenobarbital, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Aspirin, Codeine Phosphate, Phenobarbital and Methylsulfonylmethane (msm)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.