Medication interaction hub

What Supplements Interact with Aspirin, Codeine Phosphate, Phenobarbital?

Aspirin, Codeine Phosphate, Phenobarbital brand name: Phenaphen. Every interaction below applies to the brands too.

352 Interactions 12 Major 304 Moderate 36 Minor

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Alcohol is the entry I would flag first with Phenaphen (aspirin, codeine phosphate, phenobarbital): beer or wine layered onto codeine and phenobarbital can deepen sedation and, at worst, slow breathing. This medication deserves real caution with supplements. Most of the 352 interactions on file either pile onto that sedation or raise bleeding risk on top of the aspirin it contains, and 12 of them rate major.

The bleeding group is the biggest, just over 200 ingredients that can amplify aspirin's effect on platelets. St. John's wort pulls in another direction; it speeds the body's clearance of phenobarbital, so seizure and pain control can slip. A smaller set, activated charcoal included, can blunt absorption of the whole tablet and should be kept well apart from any dose. The 304 moderate and 36 minor entries mostly repeat these themes more softly, but the dozen majors come first.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Codeine Phosphate, Phenobarbital: Top Interactions at a Glance

The Aspirin, Codeine Phosphate, Phenobarbital supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 352 interacting ingredients — plus 1,100 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Codeine Phosphate, Phenobarbital Combinations Today

The Aspirin, Codeine Phosphate, Phenobarbital + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

The complete list

Every Supplement Checked Against Aspirin, Codeine Phosphate, Phenobarbital

All 1,452 ingredients in our database, ranked by severity — 352 with a Aspirin, Codeine Phosphate, Phenobarbital interaction on file and 1,100 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Straight answers

Can You Take It With Aspirin, Codeine Phosphate, Phenobarbital?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cocoa with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cocoa + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Nutmeg with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might increase or decrease the effects and adverse effects of phenobarbital.

Full Nutmeg + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Arnica with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, arnica might have additive effects with anticoagulant and antiplatelet drugs.

Full Arnica + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Octacosanol with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically si...

Full Octacosanol + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Sceletium with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Full Sceletium + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Allspice with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining allspice with an antiplatelet or anticoagulant drug might increase the risk of bleeding.

Full Allspice + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Aloe with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Aloe + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Alpha-lipoic Acid with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplate...

Full Alpha-lipoic Acid + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Alpine Ragwort with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in alpine ragwor...

Full Alpine Ragwort + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Andrographis with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Andrographis + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Anise with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise oil might increase the effects and adverse effects of codeine.

Full Anise + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Aristolochia with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aristolochia is nephrotoxic.

Full Aristolochia + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Artichoke with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.

Full Artichoke + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Asafoetida with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asafoetida might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Full Asafoetida + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Ashwagandha with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Aspen with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aspen contains salicin, a plant salicylate.

Full Aspen + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Astaxanthin with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.

Full Astaxanthin + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Atractylodes with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.

Full Atractylodes + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Babassu with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that babassu has antithrombotic effects.

Full Babassu + Aspirin, Codeine Phosphate, Phenobarbital answer

Can you take Baikal Skullcap with Aspirin, Codeine Phosphate, Phenobarbital?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.

Full Baikal Skullcap + Aspirin, Codeine Phosphate, Phenobarbital answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Codeine Phosphate, Phenobarbital is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Codeine Phosphate, Phenobarbital, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Codeine Phosphate, Phenobarbital sits in 19 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Phenobarbital (Luminal) 16 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

16 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Cytochrome P450 2C9 (Cyp2C9) Inducers 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Aspirin, Codeine Phosphate, Phenobarbital through this category.

Codeine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Aspirin, Codeine Phosphate, Phenobarbital through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Aspirin, Codeine Phosphate, Phenobarbital through this category.

Related: does Aspirin, Codeine Phosphate, Phenobarbital deplete any nutrients?

Aspirin, Codeine Phosphate, Phenobarbital has 11 reported nutrient associations in the research literature — see the Aspirin, Codeine Phosphate, Phenobarbital nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Codeine Phosphate, Phenobarbital

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Codeine Phosphate, Phenobarbital.

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Pharmacist Counseling Corner

Aspirin, Codeine Phosphate, Phenobarbital & Supplements: Common Questions

What supplements interact with Aspirin, Codeine Phosphate, Phenobarbital?
In our interaction database, 352 supplement and herbal ingredients have an interaction with Aspirin, Codeine Phosphate, Phenobarbital on file — 12 rated major, 304 moderate, and 36 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Siberian Cocklebur, St. John's Wort.
Which Aspirin, Codeine Phosphate, Phenobarbital supplement interactions are the most serious?
The 12 major-rated combinations — led by Beer, Siberian Cocklebur, St. John's Wort, Wine and 1,4-butanediol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Codeine Phosphate, Phenobarbital?
That depends entirely on which supplement. The honest answer for Aspirin, Codeine Phosphate, Phenobarbital is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Phenaphen have the same supplement interactions as Aspirin, Codeine Phosphate, Phenobarbital?
Yes — Phenaphen all contain Aspirin, Codeine Phosphate, Phenobarbital, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Codeine Phosphate, Phenobarbital deplete any vitamins or nutrients?
It might — Aspirin, Codeine Phosphate, Phenobarbital has 11 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Codeine Phosphate, Phenobarbital nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Codeine Phosphate, Phenobarbital and my other medications?
This page covers Aspirin, Codeine Phosphate, Phenobarbital against supplements and herbal ingredients. Checking Aspirin, Codeine Phosphate, Phenobarbital against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.