Drug & supplement interaction

Mugwort + Alprazolam

Alprazolam brand names: Xanax, Niravam.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Mugwort and Alprazolam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Mugwort and Alprazolam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alprazolam and Mugwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Mugwort at all — not against Alprazolam, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mugwort safety at a glance

Mugwort overall Use caution May cause allergic reactions, especially in people sensitive to ragweed and related plants.
Pregnancy Likely Unsafe When used orally. Mugwort is said to be an abortifacient and a menstrual and uterine stimulant. Read the full pregnancy detail
Breastfeeding Avoid Not enough safety information is available, so it is best avoided while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alprazolam and Mugwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Mugwort Itself Has Been Linked To

This is not an interaction — nothing below involves Alprazolam. It is the side-effect record for Mugwort on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Mugwort, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on Additional detail

    “Orally, mania has been reported in a 49-year-old male following the intake of 1 liter of an infusion thought to contain mugwort. The presence of thujone in the patient's serum and urine was confirmed, and thujone poisoning was considered to be the cause of these symptoms. Although thujone levels are normally low in mugwort, concentrations can be variable.”

    Mugwort · Natural Medicines adverse-effect record, reported in poisoning.

    1 source cited
    1. 101053. Di Lorenzo C, Ferretti F, Moro E, et al. Identification and quantification of thujone in a case of poisoning due to repeated ingestion of an infusion of Artemisia vulgaris L. J Food Sci. 2018;83(8):2257-2264.
  • Wheezing / A severe allergic reaction Worth acting on Additional detail

    “Allergy to mugwort pollen has been reported when taken orally or inhaled. Symptoms have included asthma, rhinitis, conjunctivitis, rash, and anaphylaxis.”

    Mugwort · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    4 sources cited
    1. 101049. Borghesan F, Mistrello G, Amato S, Giuffrida MG, Villalta D, Asero R. Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5. Eur Ann Allergy Clin Immunol. 2013;45(4):130-7.
    2. 101050. Kim SH, Lee SM, Park HW, et al. Chinese bellflower root anaphylaxis: IgE-binding components and cross-reactivity with mugwort and birch. Korean J Intern Med. 2009;24(3):279-82. PubMed
    3. 101051. Silva R, Lopes C, Castro E, et al. Anaphylaxis to mango fruit and crossreactivity with Artemisia vulgaris pollen. J Investig Allergol Clin Immunol. 2009;19(5):420-2.
    4. 101052. Rodrigues-Alves R, Pregal A, Pereira-Santos MC, et al. Anaphylaxis to pine nut: cross-reactivity to Artemisia vulgaris? Allergol Immunopathol (Madr). 2008;36(2):113-6. PubMed
  • A stuffy or runny nose / A skin rash Additional detail

    Recorded for Mugwort in the same Natural Medicines adverse-effect record shown under Wheezing / A severe allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Mugwort — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Alprazolam’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Alprazolam column appears here.

Special populations

Mugwort in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Mugwort is said to be an abortifacient and a menstrual and uterine stimulant.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Alprazolam Is Prescribed For, and What Mugwort Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Alprazolam is a prescription medicine with approved uses on its FDA label. Mugwort is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Alprazolam is prescribed for: Alprazolam treats generalized anxiety disorder (GAD) and panic disorder, with or without agoraphobia, in adults. These uses are supported across multiple alprazolam products, including tablets, orally disintegrating tablets, oral solution, and extended-release tablets. Xanax (tablet) is indicated for the acute treatment of GAD and for panic disorder. Xanax XR (extended-release tablet) and alprazolam extended-release tablets are indicated specifically for panic disorder with or without agoraphobia — not for GAD.

Read the rest of what Alprazolam is prescribed for

Alprazolam orally disintegrating tablets and alprazolam oral solution are indicated for both GAD and panic disorder.

Mugwort has been studied for:

  • Anxiety studied, not established Mugwort has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Mugwort for anxiety

    Although there has been interest in using oral mugwort root for anxiety, there is insufficient reliable information about the clinical effects of mugwort for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Alprazolam on your own; if you are taking Mugwort for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Mugwort or Alprazolam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Mugwort or Alprazolam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Alprazolam

This page covers Mugwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alprazolam page lists 197 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 150 moderate · 38 minor.

From our pharmacist’s overview on the Alprazolam page

“Sedation stacking is the core danger with alprazolam (Xanax), a benzodiazepine for anxiety and panic, and this list deserves genuine care rather than a quick skim. Dozens of entries, alcohol chief among them, deepen its drowsiness and can slow breathing, while an even larger group changes how the body clears the drug through the CYP3A4…”

Reviewed by 2 · Jul 18, 2026

Open the Alprazolam interaction page

One more smart check

Taking Mugwort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 87 real supplement products containing Mugwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mugwort. Even though Mugwort itself has no known interaction with Alprazolam, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mugwort and Alprazolam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mugwort
Top half

#722 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alprazolam
Top 25%

#417 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mugwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Mugwort and Alprazolam records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mugwort

What is Mugwort?

Mugwort
  • Digestive upset and poor appetite
  • Menstrual discomfort
  • Sleep support and vivid dreaming
  • Used in moxibustion (traditional Chinese medicine)
  • Mild anxiety or relaxation

Mugwort is a traditional herb used for digestion, menstrual issues, and sleep, but there is very little high-quality human research to confirm these uses. It is closely related to ragweed and can trigger allergic reactions, and it should be avoided in pregnancy. Talk with your pharmacist or doctor before using it.

Artemisia vulgaris · Asteraceae · Leaves, flowering tops, and root; sometimes essential oil · Tea, capsules, tincture, dried herb, essential oil, and moxa (used in moxibustion)

An interaction check asks whether these two react with each other — it does not ask whether Mugwort is a good idea for someone in your situation. Here is what our Mugwort record says about it on its own.

Mugwort: dosing

There is no well-established, standardized dose for mugwort. The amount in teas, capsules, and tinctures varies a lot between products.If you choose to use mugwort, follow the directions on the product label and do not exceed them. Avoid swallowing the concentrated essential oil.

From our Mugwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mugwort monograph & all interactions
Medication

About Alprazolam

What Is Alprazolam Used For?

Brand names: Xanax, Niravam

Alprazolam treats generalized anxiety disorder (GAD) and panic disorder, with or without agoraphobia, in adults. These uses are supported across multiple alprazolam products, including tablets, orally disintegrating tablets, oral solution, and extended-release tablets.

Xanax (tablet) is indicated for the acute treatment of GAD and for panic disorder. Xanax XR (extended-release tablet) and alprazolam extended-release tablets are indicated specifically for panic disorder with or without agoraphobia — not for GAD. Alprazolam orally disintegrating tablets and alprazolam oral solution are indicated for both GAD and panic disorder.

Most-Reported Side Effects for Alprazolam

From FAERS, the FDA’s public side-effect reporting system (204,912 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 13,088 reports
Fatigue 12,190 reports
Drug abuse 11,119 reports
Anxiety 10,314 reports
Headache 10,117 reports
See full Alprazolam drug information
Keep checking

Other Drugs & Mugwort

Browse every other medication we’ve checked against Mugwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Mugwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Mugwort list.

See the full Mugwort interactions page
See every supplement checked against Alprazolam, ranked by severity
Evidence & sources

Mugwort References

The 7 references that drive our Mugwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Borghesan F, Mistrello G, Amato S, Giuffrida MG, Villalta D, Asero R. Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5. Eur Ann Allergy Clin Immunol. 2013;45(4):130-7.
  4. Kim SH, Lee SM, Park HW, et al. Chinese bellflower root anaphylaxis: IgE-binding components and cross-reactivity with mugwort and birch. Korean J Intern Med. 2009;24(3):279-82. PubMed
  5. Silva R, Lopes C, Castro E, et al. Anaphylaxis to mango fruit and crossreactivity with Artemisia vulgaris pollen. J Investig Allergol Clin Immunol. 2009;19(5):420-2.
  6. Rodrigues-Alves R, Pregal A, Pereira-Santos MC, et al. Anaphylaxis to pine nut: cross-reactivity to Artemisia vulgaris? Allergol Immunopathol (Madr). 2008;36(2):113-6. PubMed
  7. Di Lorenzo C, Ferretti F, Moro E, et al. Identification and quantification of thujone in a case of poisoning due to repeated ingestion of an infusion of Artemisia vulgaris L. J Food Sci. 2018;83(8):2257-2264.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mugwort and Alprazolam Together: Common Questions

Is it safe to take Mugwort with Alprazolam?
We do not list a known interaction between Mugwort and Alprazolam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Mugwort and Alprazolam used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Mugwort in each. That is a conversation for your prescriber, especially if Alprazolam is being adjusted to a target.
Does Alprazolam interact with any supplements?
Yes. Alprazolam has documented interactions with 197 supplements in our database — Mugwort is not one of them. The Alprazolam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mugwort monograph Uses, safety profile, and every drug interaction in one place Alprazolam drug information The full plain-English guide to this medication Alprazolam supplement interactions Every supplement checked against Alprazolam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Alprazolam and Mugwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.