Drug & supplement interaction

N-methyltyramine + Codeine Phosphate, Pseudoephedrine

Codeine Phosphate, Pseudoephedrine brand names: Nucofed, Kg Fed.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

N-methyltyramine has a minor interaction with Codeine Phosphate, Pseudoephedrine. N-methyltyramine is thought to have stimulant effects.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

N-methyltyramine and Codeine Phosphate, Pseudoephedrine

Here is the interaction we found between these two, with the evidence behind it.

Minor

STIMULANT DRUGS

Why this applies to Codeine Phosphate, Pseudoephedrine

Codeine Phosphate, Pseudoephedrine falls under STIMULANT DRUGS — the group N-methyltyramine interacts with.

N-methyltyramine is thought to have stimulant effects. However, this has not been shown in humans and laboratory research does not support the proposed stimulant effects of N-methyltyramine. Theoretically, taking N-methyltyramine with other stimulant drugs might increase the risk of hypertension and adverse cardiovascular effects. Until more is known, avoid taking N-methyltyramine with stimulant drugs.
Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combo product pairs codeine (a cough suppressant) with pseudoephedrine, a decongestant that's already a stimulant. The piece that matters here is the pseudoephedrine. N-methyltyramine is believed to gently rev up your body's 'fight or flight' response, so stacking it on top of pseudoephedrine could, in theory, add up to more stimulation. That might mean a faster or pounding heartbeat, higher blood pressure, jitteriness, or trouble sleeping.

Honestly though, the evidence here is thin. This concern is based on how the compound is thought to behave, and human and lab studies haven't actually confirmed those stimulant effects. So I wouldn't panic. If you have heart trouble or high blood pressure, just run it by your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
  2. Stohs SJ, Hartman MJ. A review of the receptor binding and pharmacological effects of N-methyltyramine. Phytother Res. 2015;29(1):14-6.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

N-methyltyramine Also Interacts With Other Medications

N-methyltyramine has 343 minor known drug interactions in our database — the Codeine Phosphate, Pseudoephedrine one above is one of them. If you take anything else, check it against the full list below.

Minor 343 No known interaction 2,487 (incl. Codeine Phosphate, Pseudoephedrine)
Taking anything else?

Check Another of Your Medications Against N-methyltyramine

Covers the 2,830 medications we’ve checked against N-methyltyramine. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Codeine Phosphate, Pseudoephedrine

This page covers N-methyltyramine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Codeine Phosphate, Pseudoephedrine page lists 176 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Ephedra (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 11 major · 142 moderate · 23 minor.

From our pharmacist’s overview on the Codeine Phosphate, Pseudoephedrine page

“Alcohol is the clearest danger here. Beer and wine both carry a major rating with codeine phosphate and pseudoephedrine (Nucofed, Kg Fed), because alcohol deepens the sedation the codeine half already causes, and that effect is well documented in people.”

Reviewed by 2 · Jul 18, 2026

Open the Codeine Phosphate, Pseudoephedrine interaction page

One more smart check

Taking N-methyltyramine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 213 real supplement products containing N-methyltyramine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides N-methyltyramine. Your product may carry other ingredients that interact with Codeine Phosphate, Pseudoephedrine too, on top of N-methyltyramine — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where N-methyltyramine and Codeine Phosphate, Pseudoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement N-methyltyramine
Top half

#511 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Codeine Phosphate, Pseudoephedrine
Steady interest

#2,389 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About N-methyltyramine

What is N-methyltyramine?

  • Weight loss and fat burning
  • Energy and pre-workout supplements
  • Sports performance
  • Appetite control

N-methyltyramine is a natural compound related to tyramine that is found in bitter orange, barley, and other plants, and it is often added to weight-loss and pre-workout supplements. Solid human research on its safety and effectiveness is very limited, and because it may stimulate the body like other amines, people with heart problems or high blood pressure should be especially careful. Talk to a pharmacist or doctor before using any product that contains it.

Read the full N-methyltyramine monograph & all interactions
Keep checking

Other Drugs & N-methyltyramine

Browse every other medication we’ve checked against N-methyltyramine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
343Minor
2,486No known interaction
343 Minor 2,486 No interaction
Minor

343 interactions

Showing 60 of 343 minor interactions — see all 343 on the N-methyltyramine page.

No interaction 2,486 drugs checked — show the list

We also checked N-methyltyramine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,486 medications checked with no known interaction — see the full N-methyltyramine list.

See the full N-methyltyramine interactions page
See every supplement checked against Codeine Phosphate, Pseudoephedrine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
N-methyltyramine monograph › Uses, safety, and every drug interaction in one place Codeine Phosphate, Pseudoephedrine supplement interactions › Every supplement checked against Codeine Phosphate, Pseudoephedrine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking N-methyltyramine and Codeine Phosphate, Pseudoephedrine Together: Common Questions

Can you take N-methyltyramine with Codeine Phosphate, Pseudoephedrine?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the N-methyltyramine and Codeine Phosphate, Pseudoephedrine interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Codeine Phosphate, Pseudoephedrine and N-methyltyramine?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.