Drug & supplement interaction

Nasal Irrigation + Norelgestromin, Ethinyl Estradiol

Norelgestromin, Ethinyl Estradiol brand names: Ortho Evra, Evra.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Nasal Irrigation and Norelgestromin, Ethinyl Estradiol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone interested in this? Share
Facebook Post Reddit Email
On this page
Interaction report

Nasal Irrigation and Norelgestromin, Ethinyl Estradiol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Norelgestromin, Ethinyl Estradiol and Nasal Irrigation in our sources. This does not guarantee that the combination is completely free of risk — research on Nasal Irrigation alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Nasal Irrigation at all — not against Norelgestromin, Ethinyl Estradiol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Nasal Irrigation is used rather than swallowed. Ask your pharmacist or doctor whether it is appropriate alongside your medicines. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Nasal Irrigation safety at a glance

Nasal Irrigation overall Generally safe Generally safe when done with sterile or distilled water and a clean device.
Pregnancy Likely Safe When used appropriately. Saline solution is not harmful to the fetus or newborn. Read the full pregnancy detail
Breastfeeding Likely Safe When used appropriately. Saline solution is not harmful to the fetus or newborn. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Norelgestromin, Ethinyl Estradiol and Nasal Irrigation? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Nasal Irrigation and Norelgestromin, Ethinyl Estradiol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so using Nasal Irrigation while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Bleeding or bruising Worth acting on Additional detail

    Nasal Irrigation

    “Nasal irrigation can cause mild side effects including nasal burning, pain, stinging, discharge, and irritation, and ear fullness, ringing, and pain. Irrigation solutions with a higher concentration of salt increase these side effects. In rare cases, epistaxis, nausea, coughing, and headaches have occurred.”

    Nasal Irrigation · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    6 sources cited
    1. 16135. Saline nasal irrigation and use of neti pots. Pharmacist's Letter/Prescriber's Letter 2008;24(3):240307.
    2. 17039. Rabago D, Zgierska A. Saline nasal irrigation for upper respiratory conditions. Am Fam Physician 2009;80:1117-9. DOI
    3. 88354. Rabago D, Zgierska A, Mundt M, et al. Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial. J Fam Pract 2002;51(12):1049-55.
    4. 93984. Chusakul S, Warathanasin S, Suksangpanya N, et al.. Comparison of buffered and nonbuffered nasal saline irrigations in treating allergic rhinitis. Laryngoscope. 2013 Jan;123(1):53-6. DOI
    5. 93986. Jeffe JS, Bhushan B, Schroeder JW Jr. Nasal saline irrigation in children: a study of compliance and tolerance. Int J Pediatr Otorhinolaryngol. 2012 Mar;76(3):409-13. PubMed
    6. 93988. King D, Mitchell B, Williams CP, Spurling GK. Saline nasal irrigation for acute upper respiratory tract infections. Cochrane Database Syst Rev. 2015 Apr 20;(4):CD006821. PubMed

    “Nasal irrigation can cause side effects including nasal burning, pain, stinging, discharge, and irritation. Irrigation solutions with a higher concentration of salt increase these side effects. In rare cases, epistaxis and coughing have occurred. Nasal irrigation does not seem to negatively impact the sense of smell.”

    Nasal Irrigation · Natural Medicines adverse-effect record, reported in pain.

    6 sources cited
    1. 16135. Saline nasal irrigation and use of neti pots. Pharmacist's Letter/Prescriber's Letter 2008;24(3):240307.
    2. 17039. Rabago D, Zgierska A. Saline nasal irrigation for upper respiratory conditions. Am Fam Physician 2009;80:1117-9. DOI
    3. 88354. Rabago D, Zgierska A, Mundt M, et al. Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial. J Fam Pract 2002;51(12):1049-55.
    4. 93984. Chusakul S, Warathanasin S, Suksangpanya N, et al.. Comparison of buffered and nonbuffered nasal saline irrigations in treating allergic rhinitis. Laryngoscope. 2013 Jan;123(1):53-6. DOI
    5. 93986. Jeffe JS, Bhushan B, Schroeder JW Jr. Nasal saline irrigation in children: a study of compliance and tolerance. Int J Pediatr Otorhinolaryngol. 2012 Mar;76(3):409-13. PubMed
    6. 93988. King D, Mitchell B, Williams CP, Spurling GK. Saline nasal irrigation for acute upper respiratory tract infections. Cochrane Database Syst Rev. 2015 Apr 20;(4):CD006821. PubMed

    Norelgestromin, Ethinyl Estradiol

    Listed in the ADVERSE REACTIONS section of the FDA label for Norelgestromin, Ethinyl Estradiol. Read the label on DailyMed ›

  • A higher chance of infection Worth acting on Additional detail

    Nasal Irrigation

    “There is some concern that chronic use of nasal irrigation might actually increase the risk of sinus infection recurrence in patients with chronic rhinosinusitis. In a preliminary study, chronic users of nasal irrigation had a reduced risk of rhinosinusitis recurrence after discontinuing nasal irrigation compared to those who continued using nasal irrigation.”

    Nasal Irrigation · Natural Medicines adverse-effect record, reported in sinusitis.

    5 sources cited
    1. 17040. Nsouli TM. Long-term use of nasal saline irrigation: harmful or helpful (abstract 32). Ann Allergy Asthma Immunol 2009;103(5 Suppl 3):A27-8.
    2. 93987. Keen M, Foreman A, Wormald PJ. The clinical significance of nasal irrigation bottle contamination. Laryngoscope. 2010 Oct;120(10):2110-4. PubMed
    3. 93993. Satdhabudha A, Utispan K, Monthanapisut P, Poachanukoon O. A randomized controlled study comparing the efficacy of nasal saline irrigation devices in children with acute rhinosinusitis. Asian Pac J Allergy Immunol. 2016 Aug 16.
    4. 17911. North Louisiana woman dies from rare ameba infection. Louisiana Department of Public Health, December 6, 2011. Available at: http://new.dhh.louisiana.gov/index.cfm/newsroom/detail/2332. (Accessed 4 January 2012).
    5. 93982. Cain RB, Lal D, Barrs DM. Infected cochlear implant after large-volume nasal irrigation. Otol Neurotol. 2015 Jan;36(1):12-3. PubMed

    Norelgestromin, Ethinyl Estradiol

    Listed in the ADVERSE REACTIONS section of the FDA label for Norelgestromin, Ethinyl Estradiol. Read the label on DailyMed ›

  • Headache Additional detail

    Nasal Irrigation

    “Rarely, nasal irrigation can cause side effects such as headache.”

    Nasal Irrigation · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 88345. Holmstrom M, Rosen G, Wahlander L. Effect of nasal lavage on nasal symptoms and physiology in wood industry workers. Rhinology 1997;35(3):108-12.

    Norelgestromin, Ethinyl Estradiol

    Listed in the ADVERSE REACTIONS section of the FDA label for Norelgestromin, Ethinyl Estradiol. Read the label on DailyMed ›

  • Nausea Additional detail

    Nasal Irrigation

    “Rarely, nausea has occured.”

    Nasal Irrigation · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 93986. Jeffe JS, Bhushan B, Schroeder JW Jr. Nasal saline irrigation in children: a study of compliance and tolerance. Int J Pediatr Otorhinolaryngol. 2012 Mar;76(3):409-13. PubMed

    Norelgestromin, Ethinyl Estradiol

    Listed in the ADVERSE REACTIONS section of the FDA label for Norelgestromin, Ethinyl Estradiol. Read the label on DailyMed ›

Reported for Nasal Irrigation but not commonly for Norelgestromin, Ethinyl Estradiol: cough and fever.

Effects for Norelgestromin, Ethinyl Estradiol come from the ADVERSE REACTIONS section of its FDA label; effects for Nasal Irrigation come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Nasal Irrigation in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used appropriately. Saline solution is not harmful to the fetus or newborn.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Norelgestromin, Ethinyl Estradiol

This page covers Nasal Irrigation only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Norelgestromin, Ethinyl Estradiol page lists 203 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Activated Charcoal (moderate) and Adrafinil (moderate).

By severity: 2 major · 168 moderate · 33 minor.

From our pharmacist’s overview on the Norelgestromin, Ethinyl Estradiol page

“St. John's wort is the first entry to check if you wear the Ortho Evra patch (norelgestromin and ethinyl estradiol).”

Reviewed by 2 · Jul 18, 2026

Open the Norelgestromin, Ethinyl Estradiol interaction page

How much people look this up

Where Nasal Irrigation and Norelgestromin, Ethinyl Estradiol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Nasal Irrigation
Steady interest

#1,340 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Norelgestromin, Ethinyl Estradiol
Top 25%

#471 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nasal Irrigation reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Nasal Irrigation and Norelgestromin, Ethinyl Estradiol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Self-care method

About Nasal Irrigation

What is Nasal Irrigation?

  • Nasal congestion
  • Sinus infections (sinusitis)
  • Allergies and hay fever
  • Common cold symptoms
  • Postnasal drip
  • Dryness and crusting in the nose

Nasal irrigation is rinsing the inside of your nose with a saltwater (saline) solution to wash out mucus, allergens, and irritants. It is a low-cost, generally safe option that may ease congestion and sinus symptoms, but it must be done with distilled, sterile, or properly boiled water to avoid rare but serious infections.

Saline rinse bottles, neti pots, squeeze bottles, premixed saline packets, nasal sprays

An interaction check asks whether these two react with each other — it does not ask whether Nasal Irrigation is a good idea for someone in your situation. Here is what our Nasal Irrigation record says about it on its own.

Nasal Irrigation: dosing

There is no single official dose for nasal irrigation. Many people rinse once or twice a day when they have symptoms, but you should follow the directions on your specific product or kit.Premixed saline packets are designed to make a comfortable salt concentration, so follow the packet instructions for how much salt and water to combine. If symptoms are not improving, are getting worse, or you have signs of infection like fever, see your doctor.Always use distilled, sterile, or boiled-and-cooled water, and clean your device after each use.

From our Nasal Irrigation monograph — the full record covers uses, side effects and every documented interaction.

Read the full Nasal Irrigation monograph & all interactions
Keep checking

Other Drugs & Nasal Irrigation

Browse every other medication we’ve checked against Nasal Irrigation — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Nasal Irrigation against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Nasal Irrigation list.

See the full Nasal Irrigation interactions page
See every supplement checked against Norelgestromin, Ethinyl Estradiol, ranked by severity
Evidence & sources

Nasal Irrigation References

The 19 references that drive our Nasal Irrigation monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Saline nasal irrigation and use of neti pots. Pharmacist's Letter/Prescriber's Letter 2008;24(3):240307.
  2. Rabago D, Zgierska A. Saline nasal irrigation for upper respiratory conditions. Am Fam Physician 2009;80:1117-9. DOI
  3. Nsouli TM. Long-term use of nasal saline irrigation: harmful or helpful (abstract 32). Ann Allergy Asthma Immunol 2009;103(5 Suppl 3):A27-8.
  4. North Louisiana woman dies from rare ameba infection. Louisiana Department of Public Health, December 6, 2011. Available at: http://new.dhh.louisiana.gov/index.cfm/newsroom/detail/2332. (Accessed 4 January 2012).
  5. Holmstrom M, Rosen G, Wahlander L. Effect of nasal lavage on nasal symptoms and physiology in wood industry workers. Rhinology 1997;35(3):108-12.
  6. Rabago D, Zgierska A, Mundt M, et al. Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial. J Fam Pract 2002;51(12):1049-55.
  7. Cain RB, Lal D, Barrs DM. Infected cochlear implant after large-volume nasal irrigation. Otol Neurotol. 2015 Jan;36(1):12-3. PubMed
  8. Chusakul S, Warathanasin S, Suksangpanya N, et al.. Comparison of buffered and nonbuffered nasal saline irrigations in treating allergic rhinitis. Laryngoscope. 2013 Jan;123(1):53-6. DOI
  9. Hermelingmeier KE, Weber RK, Hellmich M, Heubach CP, Mösges R. Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy. 2012 Sep-Oct;26(5):e119-25. PubMed
  10. Jeffe JS, Bhushan B, Schroeder JW Jr. Nasal saline irrigation in children: a study of compliance and tolerance. Int J Pediatr Otorhinolaryngol. 2012 Mar;76(3):409-13. PubMed
  11. Keen M, Foreman A, Wormald PJ. The clinical significance of nasal irrigation bottle contamination. Laryngoscope. 2010 Oct;120(10):2110-4. PubMed
  12. King D, Mitchell B, Williams CP, Spurling GK. Saline nasal irrigation for acute upper respiratory tract infections. Cochrane Database Syst Rev. 2015 Apr 20;(4):CD006821. PubMed
  13. Liu JJ, Chan GC, Hecht AS, Storm DR, Davis GE. Nasal saline irrigation has no effect on normal olfaction: a prospective randomized trial. Int Forum Allergy Rhinol. 2014 Jan;4(1):39-42. PubMed
  14. Satdhabudha A, Poachanukoon O. Efficacy of buffered hypertonic saline nasal irrigation in children with symptomatic allergic rhinitis: a randomized double-blind study. Int J Pediatr Otorhinolaryngol. 2012 Apr;76(4):583-8. PubMed
  15. Satdhabudha A, Utispan K, Monthanapisut P, Poachanukoon O. A randomized controlled study comparing the efficacy of nasal saline irrigation devices in children with acute rhinosinusitis. Asian Pac J Allergy Immunol. 2016 Aug 16.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Using Nasal Irrigation While Taking Norelgestromin, Ethinyl Estradiol: Common Questions

Is it safe to use Nasal Irrigation while taking Norelgestromin, Ethinyl Estradiol?
We do not list a known interaction between Nasal Irrigation and Norelgestromin, Ethinyl Estradiol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Nasal Irrigation and Norelgestromin, Ethinyl Estradiol have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Norelgestromin, Ethinyl Estradiol interact with any supplements?
Yes. Norelgestromin, Ethinyl Estradiol has documented interactions with 203 supplements in our database — Nasal Irrigation is not one of them. The Norelgestromin, Ethinyl Estradiol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Nasal Irrigation monograph Uses, safety profile, and every drug interaction in one place Norelgestromin, Ethinyl Estradiol supplement interactions Every supplement checked against Norelgestromin, Ethinyl Estradiol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 19 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Norelgestromin, Ethinyl Estradiol and Nasal Irrigation?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.