Medication interaction hub

What Supplements Interact with Norelgestromin, Ethinyl Estradiol?

Norelgestromin, Ethinyl Estradiol brand names: Ortho Evra, Evra. Every interaction below applies to the brands too.

203 Interactions 2 Major 168 Moderate 33 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Norelgestromin, Ethinyl Estradiol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Norelgestromin, Ethinyl Estradiol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

St. John's wort is the first entry to check if you wear the Ortho Evra patch (norelgestromin and ethinyl estradiol). It revs up the liver enzyme that clears these hormones, which can drop their levels, a real problem for a medication whose job is preventing pregnancy. Grapefruit, the other major-rated entry, does the reverse, blocking that same enzyme so hormone levels climb. This list warrants genuine care, not a quick glance.

The other 201 ingredients rate moderate (168 of them) or minor (33), and two patterns cover most of the moderates. Plenty of herbs carry estrogen-like activity of their own, and dozens more nudge the same liver pathways, just less forcefully than St. John's wort does. The everyday one is caffeine, since estrogen slows how fast the body clears it. If your usual caffeine starts hitting harder or lasting longer on the patch, that interaction is the likely reason.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 168 Minor 33 No known interaction 1,249

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Norelgestromin, Ethinyl Estradiol: Top Interactions at a Glance

The Norelgestromin, Ethinyl Estradiol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 203 interacting ingredients — plus 1,249 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Norelgestromin, Ethinyl Estradiol Combinations Today

The Norelgestromin, Ethinyl Estradiol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Ilex Guayusa + Norelgestromin, Ethinyl Estradioli

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Lentinan + Norelgestromin, Ethinyl Estradioli

Laboratory evidence suggests that lentinan might increase the activity of cytochrome P450 1A2 (CYP1A2).

Read the full interaction Moderate Likelihood Possible Bacopa + Norelgestromin, Ethinyl Estradioli

Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Probable Red Clover + Norelgestromin, Ethinyl Estradioli

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Read the full interaction Minor Likelihood Possible Aegeline + Norelgestromin, Ethinyl Estradioli

Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Read the full interaction Moderate Likelihood Possible Hemp + Norelgestromin, Ethinyl Estradioli

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Norelgestromin, Ethinyl Estradiol

All 1,452 ingredients in our database, ranked by severity — 203 with a Norelgestromin, Ethinyl Estradiol interaction on file and 1,249 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Norelgestromin, Ethinyl Estradiol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ilex Guayusa with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Ilex Guayusa + Norelgestromin, Ethinyl Estradiol answer

Can you take Lentinan with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory evidence suggests that lentinan might increase the activity of cytochrome P450 1A2 (CYP1A2).

Full Lentinan + Norelgestromin, Ethinyl Estradiol answer

Can you take Bacopa with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.

Full Bacopa + Norelgestromin, Ethinyl Estradiol answer

Can you take Red Clover with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.

Full Red Clover + Norelgestromin, Ethinyl Estradiol answer

Can you take Aegeline with Norelgestromin, Ethinyl Estradiol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Norelgestromin, Ethinyl Estradiol answer

Can you take Guggul with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Norelgestromin, Ethinyl Estradiol answer

Can you take Melatonin with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.

Full Melatonin + Norelgestromin, Ethinyl Estradiol answer

Can you take Oolong Tea with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine in oolong tea.

Full Oolong Tea + Norelgestromin, Ethinyl Estradiol answer

Can you take Pu-erh Tea with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Pu-erh Tea + Norelgestromin, Ethinyl Estradiol answer

Can you take Schisandra with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Norelgestromin, Ethinyl Estradiol answer

Can you take Tree Turmeric with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Norelgestromin, Ethinyl Estradiol answer

Can you take Vitamin C with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vitamin C might increase blood levels of estrogens.

Full Vitamin C + Norelgestromin, Ethinyl Estradiol answer

Can you take Vitex Agnus-castus with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitex agnus-castus could interfere with the activity of estrogens.

Full Vitex Agnus-castus + Norelgestromin, Ethinyl Estradiol answer

Can you take Wild Carrot with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, excessive use of the above ground parts of wild carrot might interfere with hormonal therapy due to estrogenic effects of wil...

Full Wild Carrot + Norelgestromin, Ethinyl Estradiol answer

Can you take Yerba Mate with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of the caffeine in yerba mate.

Full Yerba Mate + Norelgestromin, Ethinyl Estradiol answer

Can you take Acacia Rigidula with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Norelgestromin, Ethinyl Estradiol answer

Can you take Activated Charcoal with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Activated charcoal may reduce the clinical effects of oral contraceptives.

Full Activated Charcoal + Norelgestromin, Ethinyl Estradiol answer

Can you take Adrafinil with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might reduce the levels and clinical effects of CYP1A2 substrates.

Full Adrafinil + Norelgestromin, Ethinyl Estradiol answer

Can you take African Wild Potato with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract inhibits cytochrome P450 1A2 (CYP1A2).

Full African Wild Potato + Norelgestromin, Ethinyl Estradiol answer

Can you take Aletris with Norelgestromin, Ethinyl Estradiol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aletris might have estrogenic effects.

Full Aletris + Norelgestromin, Ethinyl Estradiol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Norelgestromin, Ethinyl Estradiol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Norelgestromin, Ethinyl Estradiol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Norelgestromin, Ethinyl Estradiol sits in 11 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Norelgestromin, Ethinyl Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Norelgestromin, Ethinyl Estradiol through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Norelgestromin, Ethinyl Estradiol through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Norelgestromin, Ethinyl Estradiol through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Norelgestromin, Ethinyl Estradiol through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Norelgestromin, Ethinyl Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Norelgestromin, Ethinyl Estradiol through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Norelgestromin, Ethinyl Estradiol through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Norelgestromin, Ethinyl Estradiol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Norelgestromin, Ethinyl Estradiol through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Norelgestromin, Ethinyl Estradiol through this category.

Related: does Norelgestromin, Ethinyl Estradiol deplete any nutrients?

Norelgestromin, Ethinyl Estradiol has 14 reported nutrient associations in the research literature — see the Norelgestromin, Ethinyl Estradiol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Norelgestromin, Ethinyl Estradiol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Norelgestromin, Ethinyl Estradiol.

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Pharmacist Counseling Corner

Norelgestromin, Ethinyl Estradiol & Supplements: Common Questions

What supplements interact with Norelgestromin, Ethinyl Estradiol?
More than you might expect — 203 in total, though they are far from equal: 2 are rated major, 168 moderate, and 33 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, St. John's Wort, Black Tea.
Which Norelgestromin, Ethinyl Estradiol supplement interactions are the most serious?
The 2 major-rated combinations — led by Grapefruit and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Norelgestromin, Ethinyl Estradiol?
Usually yes — most people on Norelgestromin, Ethinyl Estradiol can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Ortho Evra have the same supplement interactions as Norelgestromin, Ethinyl Estradiol?
Yes — Ortho Evra, Evra all contain Norelgestromin, Ethinyl Estradiol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Norelgestromin, Ethinyl Estradiol deplete any vitamins or nutrients?
It might — Norelgestromin, Ethinyl Estradiol has 14 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Norelgestromin, Ethinyl Estradiol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Norelgestromin, Ethinyl Estradiol and my other medications?
This page covers Norelgestromin, Ethinyl Estradiol against supplements and herbal ingredients. Checking Norelgestromin, Ethinyl Estradiol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.