Drug & supplement interaction

Nikko Maple + Nabumetone

Nabumetone brand names: Relafen, Nabumetone.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Nikko Maple and Nabumetone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Nikko Maple and Nabumetone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nabumetone and Nikko Maple in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Nikko Maple at all — not against Nabumetone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Nikko Maple safety at a glance

Nikko Maple overall Not established There is very little safety data on Nikko Maple used as a supplement.
Pregnancy Avoid Safety is unknown, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety is unknown, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nabumetone and Nikko Maple? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Nabumetone’s Own FDA Label Lists

This is not an interaction — none of it involves Nikko Maple. These are the most notable effects listed in the ADVERSE REACTIONS section of Nabumetone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Trouble swallowing Worth acting on
  • Bleeding in the gut Worth acting on
  • Low potassium Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • High blood sugar Worth acting on
  • Fainting Worth acting on

Showing the 10 most notable of 64 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Nabumetone. Read the label on DailyMed › Where a percentage is shown, it is the share of 6,395 voluntary FDA FAERS reports for Nabumetone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Nikko Maple’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Nikko Maple side to compare — that is a limit of the record, not a statement that Nikko Maple has no side effects.

From our Q&A

Questions About Nikko Maple or Nabumetone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Nikko Maple or Nabumetone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Nabumetone

This page covers Nikko Maple only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nabumetone page lists 52 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 35 moderate · 12 minor.

From our pharmacist’s overview on the Nabumetone page

“Five of the 52 supplement and herbal ingredients on file for nabumetone (Relafen) rate major, and those five are where real vigilance belongs. Nabumetone is an NSAID taken for arthritis and joint pain, and NSAIDs already stress the stomach and the kidneys, so the worst pairings hit exactly those weak spots.”

Reviewed by 2 · Jul 18, 2026

Open the Nabumetone interaction page

How much people look this up

Where Nikko Maple and Nabumetone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Nikko Maple
Steady interest

#879 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nabumetone
Steady interest

#2,238 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Nikko Maple is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nikko Maple reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Nikko Maple and Nabumetone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Nikko Maple

What is Nikko Maple?

  • Traditional folk remedies
  • Eye and vision-related folk uses
  • General wellness/tonic use
  • Source of maple-type sap

Nikko Maple is an ornamental Asian maple tree with very little scientific study as a health supplement. There is not enough reliable evidence to recommend it for any health condition, and its safety has not been well established—so talk with your pharmacist or doctor before trying it.

Acer maximowiczianum · Sapindaceae · Bark, leaves, and sap (limited traditional use) · Not commonly sold as a standardized supplement; occasionally found as bark extracts or sap

An interaction check asks whether these two react with each other — it does not ask whether Nikko Maple is a good idea for someone in your situation. Here is what our Nikko Maple record says about it on its own.

Nikko Maple: dosing

There is no established or standardized dose for Nikko Maple. Because it is not a common, well-studied supplement, reliable dosing guidelines do not exist.If you choose to use a product that contains it, follow the directions on the label and do not exceed the recommended amount.

From our Nikko Maple monograph — the full record covers uses, side effects and every documented interaction.

Read the full Nikko Maple monograph & all interactions
Medication

About Nabumetone

What Is Nabumetone Used For?

Brand names: Relafen, Nabumetone

Nabumetone tablets — available as generic nabumetone and as the brand Relafen DS — are used to relieve pain, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis.

It is meant to be used at the lowest effective dose for the shortest time needed. It is not approved for pain relief around coronary artery bypass graft (CABG) heart surgery.

Most-Reported Side Effects for Nabumetone

From FAERS, the FDA’s public side-effect reporting system (6,395 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 376 reports
Fatigue 363 reports
Headache 319 reports
Arthralgia 312 reports
Dyspnea 245 reports
See full Nabumetone drug information
Keep checking

Other Drugs & Nikko Maple

Browse every other medication we’ve checked against Nikko Maple — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Nikko Maple against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Nikko Maple list.

See the full Nikko Maple interactions page
See every supplement checked against Nabumetone, ranked by severity
Evidence & sources

Nikko Maple References

The 2 sources that drive our Nikko Maple monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Nikko Maple is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Nikko Maple and Nabumetone Together: Common Questions

Is it safe to take Nikko Maple with Nabumetone?
We do not list a known interaction between Nikko Maple and Nabumetone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Nabumetone interact with any supplements?
Yes. Nabumetone has documented interactions with 52 supplements in our database — Nikko Maple is not one of them. The Nabumetone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Nikko Maple monograph Uses, safety profile, and every drug interaction in one place Nabumetone drug information The full plain-English guide to this medication Nabumetone supplement interactions Every supplement checked against Nabumetone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nabumetone and Nikko Maple?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.