Drug & supplement interaction

Norway Spruce + Crizotinib

Crizotinib brand name: Xalkori.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Norway Spruce and Crizotinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Norway Spruce and Crizotinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Crizotinib and Norway Spruce in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Norway Spruce at all — not against Crizotinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Norway Spruce safety at a glance

Norway Spruce overall Use caution Generally tolerated in food amounts, but the essential oil is concentrated and can irritate skin or airways.
Pregnancy Avoid Not enough safety data; avoid medicinal or essential oil use during pregnancy.
Breastfeeding Avoid Safety is unknown while breastfeeding, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Crizotinib and Norway Spruce? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Crizotinib’s Own FDA Label Lists

This is not an interaction — none of it involves Norway Spruce. These are the most notable effects listed in the ADVERSE REACTIONS section of Crizotinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Muscle weakness Worth acting on
  • Trouble swallowing Worth acting on
  • Unsteadiness Worth acting on
  • A slow heartbeat Worth acting on
  • Blood clots Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on
  • A low platelet count Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on

Showing the 10 most notable of 36 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Crizotinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 12,638 voluntary FDA FAERS reports for Crizotinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Norway Spruce’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Norway Spruce side to compare — that is a limit of the record, not a statement that Norway Spruce has no side effects.

Everything else you take

See Every Supplement That Interacts With Crizotinib

This page covers Norway Spruce only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Crizotinib page lists 157 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 112 moderate · 37 minor.

From our pharmacist’s overview on the Crizotinib page

“Grapefruit tops my worry list for crizotinib (Xalkori), a targeted pill for ALK-positive lung cancer. It blocks the enzyme (CYP3A4) that clears crizotinib, letting levels climb and side effects with them, and it is one of eight major-rated entries among the 157 supplements and herbs on file for this drug.”

Reviewed by 2 · Jul 18, 2026

Open the Crizotinib interaction page

How much people look this up

Where Norway Spruce and Crizotinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Norway Spruce
Steady interest

#1,297 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Crizotinib
Steady interest

#1,858 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Norway Spruce and Crizotinib records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Norway Spruce

What is Norway Spruce?

  • Coughs and chest congestion
  • Sore muscles and joint discomfort
  • Inhalation for stuffy nose
  • Antimicrobial and wound care (traditional)
  • Mild antioxidant support

Norway Spruce is an evergreen tree whose needles, shoots, bark, and essential oil have long been used in traditional medicine for coughs, congestion, and sore muscles. Solid human research is very limited, so most uses rest on tradition and lab studies. Use it cautiously, especially the concentrated essential oil, and talk to your pharmacist or doctor before using it medicinally.

Picea abies · Pinaceae · Needles, young shoots, bark, resin, and essential oil · Essential oil, tea (from needles or shoots), syrup, extracts, and topical balms

An interaction check asks whether these two react with each other — it does not ask whether Norway Spruce is a good idea for someone in your situation. Here is what our Norway Spruce record says about it on its own.

Norway Spruce: dosing

There is no standardized or well-established medicinal dose for Norway Spruce. Traditional use varies widely depending on whether you are using a tea, syrup, extract, or essential oil.If you use a commercial product, follow the directions on the label exactly.

From our Norway Spruce monograph — the full record covers uses, side effects and every documented interaction.

Read the full Norway Spruce monograph & all interactions
Medication

About Crizotinib

What Is Crizotinib Used For?

Brand name: Xalkori

Xalkori (crizotinib) is used to treat adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors test positive for the ALK or ROS1 gene abnormality, as confirmed by an FDA-approved test.

Xalkori is also used to treat pediatric patients aged 1 year and older and young adults with relapsed or refractory systemic ALK-positive anaplastic large cell lymphoma (ALCL). Additionally, it treats adult and pediatric patients aged 1 year and older with unresectable, recurrent, or refractory ALK-positive inflammatory myofibroblastic tumor (IMT). Note: Xalkori's safety and effectiveness in older adults with relapsed or refractory ALK-positive ALCL have not been established.

Most-Reported Side Effects for Crizotinib

From FAERS, the FDA’s public side-effect reporting system (12,638 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Disease progression 1,216 reports
Nausea 1,118 reports
Neoplasm progression 1,112 reports
Diarrhea 846 reports
Vomiting 795 reports
See full Crizotinib drug information
Keep checking

Other Drugs & Norway Spruce

Browse every other medication we’ve checked against Norway Spruce — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Norway Spruce against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Norway Spruce list.

See the full Norway Spruce interactions page
See every supplement checked against Crizotinib, ranked by severity
Sources

Sources & How We Checked

We checked Norway Spruce against Crizotinib in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Norway Spruce monograph › Uses, safety, and every drug interaction in one place Crizotinib supplement interactions › Every supplement checked against Crizotinib, ranked by severity Crizotinib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Norway Spruce and Crizotinib Together: Common Questions

Is it safe to take Norway Spruce with Crizotinib?
We do not list a known interaction between Norway Spruce and Crizotinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Crizotinib interact with any supplements?
Yes. Crizotinib has documented interactions with 157 supplements in our database — Norway Spruce is not one of them. The Crizotinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Crizotinib and Norway Spruce?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.