Omega-6 Fatty Acids + Cinacalcet
Cinacalcet brand name: Sensipar.
We found no known interaction between Omega-6 Fatty Acids and Cinacalcet in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cinacalcet states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Omega-6 Fatty Acids and Cinacalcet
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Cinacalcet and Omega-6 Fatty Acids in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Omega-6 Fatty Acids at all — not against Cinacalcet, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Omega-6 Fatty Acids safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Omega-6 Fatty Acids in Pregnancy & Breastfeeding
When consumed as part of the diet in amounts between 5% and 10% of daily calories according to the Dietary Reference Intake (DRI) Acceptable Macronutrient Distribution Range (AMDR).
When high amounts of omega-6 fatty acids are consumed in the diet. Population research suggests that the highest maternal intakes of omega-6 fatty acids (15.2-47.6 grams or 137-428 kcal daily) during pregnancy is associated with a 2.4-times greater odds of giving birth to an infant below the 10th percentile for birth weight when compared with the lowest maternal intakes (0.4-5.7 grams daily). In addition, population research in women with a history of atopy suggests that the highest blood levels of omega-6 fatty acids during the second trimester is associated with an increased odds of having a child develop atopic dermatitis by age 4-6 years when compared with the lowest intakes. There is insufficient reliable information available about supplemental omega-6 fatty acids; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Cinacalcet Products Have a Food Rule — Omega-6 Fatty Acids Should Not Break It
At least one FDA label for a product containing Cinacalcet says to take it with food. If you take Omega-6 Fatty Acids on an empty stomach out of habit, keep them separate — and take Cinacalcet with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cinacalcet products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Cinacalcet tablets should be taken with food or shortly after a meal ( 2.1 ) • Tablets should always be taken whole and not divided ( 2.1 ) • Secondary HPT in patients with CKD on dialysis ( 2.2 ): o Starting dose is 30 mg once daily.
From the Dosage and Administration section of the FDA label we read for Cinacalcet — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Cinacalcet Is Prescribed For, and What Omega-6 Fatty Acids Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Cinacalcet is a prescription medicine with approved uses on its FDA label. Omega-6 Fatty Acids is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Cinacalcet is prescribed for: Cinacalcet tablets are used to treat secondary hyperparathyroidism (overactive parathyroid glands caused by kidney disease) in adult patients with chronic kidney disease (CKD) who are on dialysis. This use applies to cinacalcet tablets, cinacalcet hydrochloride tablets, and Sensipar. Importantly, cinacalcet is not approved for CKD patients who are not on dialysis, due to a higher risk of dangerously low calcium levels. Cinacalcet tablets are also used to lower high calcium levels (hypercalcemia) in adults with parathyroid carcinoma (a rare cancer of the parathyroid gland), and in adults with primary hyperparathyroidism who need surgery based on their calcium levels but cannot have that surgery.
Omega-6 Fatty Acids has been studied for:
-
Cancer studied, not established Omega-6 Fatty Acids has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Omega-6 Fatty Acids for cancer
It is unclear if increased dietary intake of omega-6 fatty acids is beneficial for cancer prevention.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Cinacalcet on your own; if you are taking Omega-6 Fatty Acids for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Cinacalcet
This page covers Omega-6 Fatty Acids only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cinacalcet page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Cinacalcet page
“Cinacalcet (Sensipar) is dosed carefully against blood calcium and parathyroid hormone levels, usually in people with kidney disease, so anything that changes how much of a dose actually gets absorbed deserves real attention. All 17 supplement interactions on file share a single mechanism.”
Reviewed by 2 · Jul 18, 2026
Taking Omega-6 Fatty Acids as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2 real supplement products containing Omega-6 Fatty Acids, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Omega-6 Fatty Acids. Even though Omega-6 Fatty Acids itself has no known interaction with Cinacalcet, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Omega-6 Fatty Acids and Cinacalcet Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,421 of 1,452 supplements looked up here in the last 7 days
#1,379 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Omega-6 Fatty Acids reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Omega-6 Fatty Acids and Cinacalcet records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Omega-6 Fatty Acids
What is Omega-6 Fatty Acids?
- General nutrition and energy
- Skin conditions like eczema
- Inflammation support
- Heart and cholesterol health
- Nerve health (such as diabetic nerve discomfort)
Omega-6 fatty acids are essential fats your body needs but cannot make on its own, and most people get plenty from everyday foods like vegetable oils, nuts, and seeds. Supplements such as evening primrose or borage oil are sometimes used for skin or other concerns, but the evidence for added benefit is mixed, and balancing omega-6 with omega-3 fats matters more than taking more omega-6. Talk with your pharmacist or doctor before adding a supplement.
Dietary fats from plant oils, seeds, nuts, and some animal sources · Vegetable oils (corn, soybean, sunflower, safflower), capsules, evening primrose oil, borage oil, and softgels
An interaction check asks whether these two react with each other — it does not ask whether Omega-6 Fatty Acids is a good idea for someone in your situation. Here is what our Omega-6 Fatty Acids record says about it on its own.
Omega-6 Fatty Acids: dosing
There is no single standardized dose of omega-6 fatty acids that works for everyone, and most people meet their needs through diet alone. Health organizations describe omega-6 as an essential nutrient but focus on overall fat balance rather than a specific supplement amount.For supplements like evening primrose oil or borage oil, the right amount depends on the specific product and the GLA content.
From our Omega-6 Fatty Acids monograph — the full record covers uses, side effects and every documented interaction.
About Cinacalcet
What Is Cinacalcet Used For?
Brand name: Sensipar
Cinacalcet tablets are used to treat secondary hyperparathyroidism (overactive parathyroid glands caused by kidney disease) in adult patients with chronic kidney disease (CKD) who are on dialysis. This use applies to cinacalcet tablets, cinacalcet hydrochloride tablets, and Sensipar. Importantly, cinacalcet is not approved for CKD patients who are not on dialysis, due to a higher risk of dangerously low calcium levels.
Cinacalcet tablets are also used to lower high calcium levels (hypercalcemia) in adults with parathyroid carcinoma (a rare cancer of the parathyroid gland), and in adults with primary hyperparathyroidism who need surgery based on their calcium levels but cannot have that surgery.
Most-Reported Side Effects for Cinacalcet
From FAERS, the FDA’s public side-effect reporting system (48,763 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Omega-6 Fatty Acids
Browse every other medication we’ve checked against Omega-6 Fatty Acids — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Omega-6 Fatty Acids against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Omega-6 Fatty Acids list.
Omega-6 Fatty Acids References
The 20 references that drive our Omega-6 Fatty Acids monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Godley PA. Essential fatty acid consumption and risk of breast cancer. Breast Cancer Res Treat 1995;35:91-5. PubMed
- Newcomer LM, King IB, Wicklund KG, Stanford JL. The association of fatty acids with prostate cancer risk. Prostate 2001;47:262-8. DOI
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate. Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/books/03 DOI
- Colter, A. L., Cutler, C., and Meckling, K. A. Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study. Nutr J 2008;7:8. PubMed
- Yamada, T., Strong, J. P., Ishii, T., Ueno, T., Koyama, M., Wagayama, H., Shimizu, A., Sakai, T., Malcom, G. T., and Guzman, M. A. Atherosclerosis and omega-3 fatty acids in the populations of a fishing village and a farming village in Japan. Atheroscler
- Conklin, S. M., Manuck, S. B., Yao, J. K., Flory, J. D., Hibbeln, J. R., and Muldoon, M. F. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom.Med. 2007;69(9):932-934.
- Richardson, A. J., Cyhlarova, E., and Ross, M. A. Omega-3 and omega-6 fatty acid concentrations in red blood cell membranes relate to schizotypal traits in healthy adults. Prostaglandins Leukot.Essent.Fatty Acids 2003;69(6):461-466. PubMed
- Assies, J., Lok, A., Bockting, C. L., Weverling, G. J., Lieverse, R., Visser, I., Abeling, N. G., Duran, M., and Schene, A. H. Fatty acids and homocysteine levels in patients with recurrent depression: an explorative pilot study. Prostaglandins Leukot.Es PubMed
- Chiplonkar, S. A., Agte, V. V., Tarwadi, K. V., Paknikar, K. M., and Diwate, U. P. Micronutrient deficiencies as predisposing factors for hypertension in lacto-vegetarian Indian adults. J Am Coll.Nutr 2004;23(3):239-247. PubMed
- Mamalakis, G., Kiriakakis, M., Tsibinos, G., Hatzis, C., Flouri, S., Mantzoros, C., and Kafatos, A. Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents. Pharmacol.Biochem.Behav. 2006;85(2):474-479. PubMed
- Okuyama, H., Ichikawa, Y., Sun, Y., Hamazaki, T., and Lands, W. E. Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. World Rev Nutr Diet. 2007;96:143-1
- Martinez-Ramirez, M. J., Palma, S., Martinez-Gonzalez, M. A., Delgado-Martinez, A. D., de la Fuente, C., and Delgado-Rodriguez, M. Dietary fat intake and the risk of osteoporotic fractures in the elderly. Eur.J Clin Nutr 2007;61(9):1114-1120. PubMed
- Sonestedt, E., Gullberg, B., and Wirfalt, E. Both food habit change in the past and obesity status may influence the association between dietary factors and postmenopausal breast cancer. Public Health Nutr 2007;10(8):769-779. PubMed
- Simopoulos, A. P. The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac.J Clin Nutr 2008;17 Suppl 1:131-134.
- Harris, W. S., Mozaffarian, D., Rimm, E., Kris-Etherton, P., Rudel, L. L., Appel, L. J., Engler, M. M., Engler, M. B., and Sacks, F. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition DOI
- Godley, P. A., Campbell, M. K., Gallagher, P., Martinson, F. E., Mohler, J. L., and Sandler, R. S. Biomarkers of essential fatty acid consumption and risk of prostatic carcinoma. Cancer Epidemiol.Biomarkers Prev. 1996;5(11):889-895.
- Lee E, Kim H, Kim H, Ha EH, Chang N. Association of maternal omega-6 fatty acid intake with infant birth outcomes: Korean Mothers and Children's Environmental Health (MOCEH). Nutr J 2018;17(1):47. PubMed
- Pawelczyk T, Trafalska E, Pawelczyk A, Kotlicka-Antczak M. Differences in omega-3 and omega-6 polyunsaturated fatty acid consumption in people at ultra-high risk of psychosis, first-episode schizophrenia, and in healthy controls. Early Interv Psychiatry 2
- Gardner KG, Gebretsadik T, Hartman TJ, et al. Prenatal omega-3 and omega-6 polyunsaturated fatty acids and childhood atopic dermatitis. J Allergy Clin Immunol Pract. 2020;8(3):937-944. PubMed
- Luo J, Ge H, Sun J, Hao K, Yao W, Zhang D. Associations of dietary ?-3, ?-6 fatty acids consumption with sleep disorders and sleep duration among adults. Nutrients 2021;13(5):1475. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Omega-6 Fatty Acids and Cinacalcet Together: Common Questions
Is it safe to take Omega-6 Fatty Acids with Cinacalcet?
Do Omega-6 Fatty Acids and Cinacalcet have any of the same side effects?
Should I take Omega-6 Fatty Acids and Cinacalcet at the same time of day?
Are Omega-6 Fatty Acids and Cinacalcet used for the same thing?
Does Cinacalcet interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Cinacalcet and Omega-6 Fatty Acids?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.