Drug & supplement interaction

Orchic Extract + Promethazine

Promethazine brand name: Phenergan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Orchic Extract and Promethazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Orchic Extract and Promethazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Promethazine and Orchic Extract in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Orchic Extract at all — not against Promethazine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Orchic Extract safety at a glance

Orchic Extract overall Use caution Human safety and effectiveness data are very limited, and animal-tissue products carry quality and contamination concerns.
Pregnancy Avoid There is no safety data, so it should be avoided during pregnancy.
Breastfeeding Avoid There is no safety data, so it should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Promethazine and Orchic Extract? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Promethazine’s Own FDA Label Lists

This is not an interaction — none of it involves Orchic Extract. These are the most notable effects listed in the ADVERSE REACTIONS section of Promethazine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Hallucinations Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Wheezing Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • A low platelet count Worth acting on
  • Hives Worth acting on
  • A low white blood cell count Worth acting on
  • Bleeding or bruising Worth acting on

Showing the 10 most notable of 26 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Promethazine. Read the label on DailyMed › Where a percentage is shown, it is the share of 22,361 voluntary FDA FAERS reports for Promethazine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Orchic Extract’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Orchic Extract side to compare — that is a limit of the record, not a statement that Orchic Extract has no side effects.

From our Q&A

Questions About Orchic Extract or Promethazine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Orchic Extract or Promethazine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Promethazine

This page covers Orchic Extract only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Promethazine page lists 83 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Alfalfa (moderate) and Angel's Trumpet (moderate).

By severity: 3 major · 57 moderate · 23 minor.

From our pharmacist’s overview on the Promethazine page

“Promethazine (Phenergan) is a phenothiazine antihistamine used for allergies, nausea, and motion sickness, and it is strongly anticholinergic on its own, causing dry mouth, blurred vision, drowsiness, and constipation. That is why the 83 supplements and herbs on this list deserve real attention, starting with the three rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Promethazine interaction page

One more smart check

Taking Orchic Extract as Part of a Dietary Supplement Product? Check It for Interactions

We hold 177 real supplement products containing Orchic Extract, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Orchic Extract. Even though Orchic Extract itself has no known interaction with Promethazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Orchic Extract and Promethazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Orchic Extract
Top half

#441 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Promethazine
Steady interest

#2,040 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Orchic Extract reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Orchic Extract and Promethazine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Orchic Extract

What is Orchic Extract?

  • Low testosterone or male vitality
  • Sexual performance and libido support
  • Athletic performance and muscle building
  • General 'glandular' health support

Orchic extract is a glandular supplement made from the testicle tissue of animals, usually cattle. It is marketed for testosterone and male vitality, but there is essentially no reliable human evidence that it works, and quality and safety standards for animal-derived glandulars vary widely. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Testicular tissue (testis) from cattle or other animals · Capsules, tablets, powders (often in glandular supplement blends)

An interaction check asks whether these two react with each other — it does not ask whether Orchic Extract is a good idea for someone in your situation. Here is what our Orchic Extract record says about it on its own.

Orchic Extract: dosing

There is no established or standardized dose for orchic extract. Because it has not been properly studied, no amount has been shown to be safe or effective.If you choose to use a product, follow the dose printed on the label and do not exceed it.

From our Orchic Extract monograph — the full record covers uses, side effects and every documented interaction.

Read the full Orchic Extract monograph & all interactions
Medication

About Promethazine

What Is Promethazine Used For?

Brand name: Phenergan

Promethazine is used for a wide range of conditions. Tablets, oral solution, and rectal suppositories (brands including Phenergan, Promethegan, and Phenadoz) are approved for seasonal and perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, hives (urticaria), angioedema, dermographism, and allergic reactions to blood or plasma. They are also used for motion sickness (both prevention and active treatment), nausea and vomiting related to anesthesia and surgery, sedation, and as a helper medication alongside pain relievers after surgery.

Promethazine hydrochloride injection (brands including Phenergan and Promethazine HCl injection) is used for many of the same purposes but is reserved for situations where oral treatment is not possible — including allergic emergencies as an adjunct to epinephrine, sedation during labor, and as an aid during certain surgical procedures such as bronchoscopy and eye surgery.

Most-Reported Side Effects for Promethazine

From FAERS, the FDA’s public side-effect reporting system (22,614 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dependence 3,586 reports
Nausea 2,646 reports
Vomiting 1,802 reports
Fatigue 1,496 reports
Diarrhea 1,341 reports
See full Promethazine drug information
Keep checking

Other Drugs & Orchic Extract

Browse every other medication we’ve checked against Orchic Extract — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Orchic Extract against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Orchic Extract list.

See the full Orchic Extract interactions page
See every supplement checked against Promethazine, ranked by severity
Evidence & sources

Orchic Extract References

The 2 references that drive our Orchic Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. ORCHIC PMG (Protomorphogen). Natural Health Cod. www.nbizz.com/naturalhealthdoc/listings/184.html (Accessed 9 November 2000).
  2. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Orchic Extract and Promethazine Together: Common Questions

Is it safe to take Orchic Extract with Promethazine?
We do not list a known interaction between Orchic Extract and Promethazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Promethazine interact with any supplements?
Yes. Promethazine has documented interactions with 83 supplements in our database — Orchic Extract is not one of them. The Promethazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Orchic Extract monograph Uses, safety profile, and every drug interaction in one place Promethazine drug information The full plain-English guide to this medication Promethazine supplement interactions Every supplement checked against Promethazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Promethazine and Orchic Extract?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.