Drug & supplement interaction

Pagoda Tree + Valbenazine Tosylate

Valbenazine Tosylate brand name: Ingrezza.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Pagoda Tree and Valbenazine Tosylate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Pagoda Tree and Valbenazine Tosylate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Valbenazine Tosylate and Pagoda Tree in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pagoda Tree safety at a glance

Pagoda Tree overall Use caution Generally used in traditional medicine, but human safety data are limited, so use cautiously.

Pregnancy Possibly Unsafe When the seed is used orally; avoid using. There is insufficient reliable information available about the safety of the fruit when used orally during pregnancy... Read the full pregnancy detail

Breastfeeding Possibly Unsafe When the seed is used orally; avoid using. There is insufficient reliable information available about the safety of the fruit when used orally during pregnancy... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Valbenazine Tosylate and Pagoda Tree? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Valbenazine Tosylate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Valbenazine Tosylate is filed under 5 classifications — including qt interval-prolonging drugs, cytochrome p450 2d6 (cyp2d6) substrates, cns depressants. Pagoda Tree has documented interactions with 1 drug class — the most serious being caffeine (moderate) — and none of Valbenazine Tosylate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pagoda Tree Does Interact With Other Medications

Pagoda Tree has 29 moderate known drug interactions in our database — Valbenazine Tosylate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 29 No known interaction 2,801 (incl. Valbenazine Tosylate)

Taking anything else?

Check Another of Your Medications Against Pagoda Tree

Covers the 2,830 medications we’ve checked against Pagoda Tree. Pick one to open its full report.

What to actually watch for

What Pagoda Tree Itself Has Been Linked To

This is not an interaction — nothing below involves Valbenazine Tosylate. It is the side-effect record for Pagoda Tree on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Pagoda Tree, this list is the first place to look.

Swelling Additional detail
“Orally, pagoda tree flower and fruit seem to be well tolerated. No adverse effects have been reported; however, a thorough evaluation of safety outcomes has not been conducted. The pagoda tree seed is possibly unsafe when consumed long-term.

Serious Adverse Effects (Rare):

Orally: With use of the seed, death and edema.”

Pagoda Tree · Natural Medicines adverse-effect record, reported in pregnancy-related edema.
“Orally, using pagoda tree seed long-term may cause edema and death (18).”

Pagoda Tree · Natural Medicines adverse-effect record, reported in pregnancy-related edema.
1 source cited

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Pagoda Tree — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Valbenazine Tosylate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Valbenazine Tosylate column appears here.

Special populations

Pagoda Tree in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When the seed is used orally; avoid using. There is insufficient reliable information available about the safety of the fruit when used orally during pregnancy or lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Valbenazine Tosylate

This page covers Pagoda Tree only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Valbenazine Tosylate page lists 216 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 14 major · 164 moderate · 38 minor.

From our pharmacist’s overview on the Valbenazine Tosylate page

“The list for valbenazine (Ingrezza), the medicine for tardive dyskinesia, warrants genuine care, since 14 of its 216 supplement and herbal interactions are rated major. Most of those majors either pile extra sedation onto a drug that can already make people drowsy, alcohol being the everyday example, or shift how much valbenazine reach…”

Reviewed by 2 · Jul 18, 2026

Open the Valbenazine Tosylate interaction page

One more smart check

Taking Pagoda Tree as Part of a Dietary Supplement Product? Check It for Interactions

We hold 162 real supplement products containing Pagoda Tree, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pagoda Tree. Even though Pagoda Tree itself has no known interaction with Valbenazine Tosylate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pagoda Tree and Valbenazine Tosylate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pagoda Tree

Top half

#489 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Valbenazine Tosylate

Top 10%

#266 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pagoda Tree reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pagoda Tree and Valbenazine Tosylate records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Pagoda Tree

What is Pagoda Tree?

Supporting blood vessel and capillary health
Bleeding-related complaints (traditional use)
Source of the flavonoid rutin
General antioxidant support
Skin and circulation health (topical/cosmetic use)

Pagoda Tree (Styphnolobium japonicum, also called the Japanese pagoda tree) is a traditional Asian medicinal plant best known as a natural source of the flavonoid rutin. While it has a long history in traditional Chinese medicine and some lab interest, strong human evidence for most uses is limited. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or take other medicines.

Styphnolobium japonicum · Fabaceae · Flowers, flower buds, and fruit (pods); sometimes leaves · Dried flower buds, teas, powders, capsules, and standardized extracts

An interaction check asks whether these two react with each other — it does not ask whether Pagoda Tree is a good idea for someone in your situation. Here is what our Pagoda Tree record says about it on its own.

Pagoda Tree: dosing

There is no well-established standard dose of Pagoda Tree for any health condition. Traditional preparations and modern supplements vary widely in strength and form.If you choose to use a product, follow the directions on the label and do not exceed the suggested amount.

From our Pagoda Tree monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pagoda Tree monograph & all interactions

Medication

About Valbenazine

What Is Valbenazine Used For?

Brand name: Ingrezza

Valbenazine — sold as Ingrezza and INGREZZA Sprinkle — is approved for two conditions in adults. The first is tardive dyskinesia, a movement disorder that causes uncontrolled, repetitive facial or body movements, often brought on by long-term use of certain psychiatric medications. The second is chorea associated with Huntington's disease, which refers to the involuntary, dance-like jerking movements that are a hallmark of that condition.

Both Ingrezza and INGREZZA Sprinkle are approved for both of these uses.

See full Valbenazine drug information

Keep checking

Other Drugs & Pagoda Tree

Browse every other medication we’ve checked against Pagoda Tree — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

29Moderate

0Minor

2,800No known interaction

29 Moderate 2,800 No interaction

Moderate

29 interactions

No interaction 2,800 drugs checked — show the list

We also checked Pagoda Tree against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,800 medications checked with no known interaction — see the full Pagoda Tree list.

See the full Pagoda Tree interactions page

See every supplement checked against Valbenazine Tosylate, ranked by severity

Evidence & sources

Pagoda Tree References

The 2 references that drive our Pagoda Tree monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pagoda Tree and Valbenazine Tosylate Together: Common Questions

Is it safe to take Pagoda Tree with Valbenazine Tosylate?

We do not list a known interaction between Pagoda Tree and Valbenazine Tosylate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Pagoda Tree and Valbenazine Tosylate combination checked?

Interactions in our licensed database are recorded against drug classes. Valbenazine Tosylate is filed under 5 classifications, and Pagoda Tree has documented interactions with 1 drug class — none of Valbenazine Tosylate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Pagoda Tree interact with any other medications?

Yes. Pagoda Tree has 29 documented drug interactions in our database — Valbenazine Tosylate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Valbenazine Tosylate interact with any supplements?

Yes. Valbenazine Tosylate has documented interactions with 216 supplements in our database — Pagoda Tree is not one of them. The Valbenazine Tosylate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pagoda Tree monograph Uses, safety profile, and every drug interaction in one place Valbenazine drug information The full plain-English guide to this medication Valbenazine Tosylate supplement interactions Every supplement checked against Valbenazine Tosylate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Valbenazine Tosylate and Pagoda Tree?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.