Pangamic Acid + Bendamustine Hydrochloride
Bendamustine Hydrochloride brand name: Bendeka.
We found no known interaction between Pangamic Acid and Bendamustine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Pangamic Acid and Bendamustine Hydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Bendamustine Hydrochloride and Pangamic Acid in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Pangamic Acid at all — not against Bendamustine Hydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Pangamic Acid safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Pangamic Acid in Pregnancy & Breastfeeding
When used orally; avoid using because it is difficult to know what constituents are present. Dichloroacetate, present in some formulations, is mutagenic according to the Ames test.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Bendamustine Hydrochloride Is Prescribed For, and What Pangamic Acid Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Bendamustine Hydrochloride is a prescription medicine with approved uses on its FDA label. Pangamic Acid is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Bendamustine Hydrochloride is prescribed for: Bendamustine hydrochloride injection is used to treat adults with chronic lymphocytic leukemia (CLL). It is also used for adults with indolent B-cell non-Hodgkin lymphoma (NHL) — a slow-growing type of blood cancer — when the disease has continued to progress during or within six months of treatment with rituximab or a rituximab-containing regimen. For CLL, how well bendamustine works compared to other first-line treatments (aside from chlorambucil) has not been fully established.
Pangamic Acid has been studied for:
-
Cancer studied, not established Pangamic Acid has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Pangamic Acid for cancer
Although there has been interest in using oral pangamic acid for cancer, there is insufficient reliable information about the clinical effects of pangamic acid for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Bendamustine Hydrochloride on your own; if you are taking Pangamic Acid for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Bendamustine Hydrochloride
This page covers Pangamic Acid only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bendamustine Hydrochloride page lists 86 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Acerola (moderate), Adrafinil (moderate), African Wild Potato (moderate), Alpha-lipoic Acid (moderate) and Ashitaba (moderate).
By severity: 62 moderate · 24 minor.
From our pharmacist’s overview on the Bendamustine Hydrochloride page
“Bendamustine (Bendeka), a chemotherapy used for certain leukemias and lymphomas, carries 86 supplement and herbal interactions on file, and none of them rates major, so this is a watch-and-adjust list rather than an alarm. Nearly all of the entries, about 80, involve the same liver enzyme, CYP1A2, which helps process bendamustine.”
Reviewed by 2 · Jul 18, 2026
Taking Pangamic Acid as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1 real supplement products containing Pangamic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pangamic Acid. Even though Pangamic Acid itself has no known interaction with Bendamustine Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Pangamic Acid and Bendamustine Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#667 of 1,452 supplements looked up here in the last 7 days
#427 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pangamic Acid reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Pangamic Acid and Bendamustine Hydrochloride records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Pangamic Acid
What is Pangamic Acid?
- Claimed athletic performance and endurance
- General fatigue and energy
- Heart and circulation support
- Detoxification claims
- Antioxidant claims
Pangamic acid, often marketed as 'vitamin B15,' is not a true vitamin and has no established health benefit. Its chemical makeup has never been consistent across products, some versions have raised safety concerns, and it is not approved as a supplement in the United States. We do not recommend using it.
Not a plant part; a synthetic or apricot-kernel-derived chemical compound · Tablets, capsules (often labeled 'B15' or 'vitamin B15')
An interaction check asks whether these two react with each other — it does not ask whether Pangamic Acid is a good idea for someone in your situation. Here is what our Pangamic Acid record says about it on its own.
Pangamic Acid: dosing
There is no established or recommended dose for pangamic acid, and no health authority endorses its use. In most cases, the best advice is to choose a different, well-studied option instead.
From our Pangamic Acid monograph — the full record covers uses, side effects and every documented interaction.
About Bendamustine Injection
What Is Bendamustine Injection Used For?
Brand name: Bendeka
Bendamustine hydrochloride injection is used to treat adults with chronic lymphocytic leukemia (CLL). It is also used for adults with indolent B-cell non-Hodgkin lymphoma (NHL) — a slow-growing type of blood cancer — when the disease has continued to progress during or within six months of treatment with rituximab or a rituximab-containing regimen.
For CLL, how well bendamustine works compared to other first-line treatments (aside from chlorambucil) has not been fully established.
Most-Reported Side Effects for Bendamustine Hydrochloride
From FAERS, the FDA’s public side-effect reporting system (11,906 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Pangamic Acid
Browse every other medication we’ve checked against Pangamic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Pangamic Acid against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Pangamic Acid list.
Pangamic Acid References
The 1 references that drive our Pangamic Acid monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Bendamustine Hydrochloride Is Linked to Lower Levels of One Nutrient
Natural Medicines records Bendamustine Hydrochloride as a medicine that can lower these. This is not an interaction with Pangamic Acid — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Bendamustine Hydrochloride nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Pangamic Acid and Bendamustine Hydrochloride Together: Common Questions
Is it safe to take Pangamic Acid with Bendamustine Hydrochloride?
Are Pangamic Acid and Bendamustine Hydrochloride used for the same thing?
Does Bendamustine Hydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Bendamustine Hydrochloride and Pangamic Acid?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.