Drug & supplement interaction

Peanut Oil + Lidocaine

Lidocaine brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Peanut Oil and Lidocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Peanut Oil and Lidocaine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lidocaine and Peanut Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Peanut Oil at all — not against Lidocaine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Peanut Oil safety at a glance

Peanut Oil overall Use caution Generally safe as a food, but it can trigger reactions in people with peanut allergy.
Pregnancy Use caution Fine in normal food amounts; avoid concentrated supplemental or medicinal use unless cleared by your doctor.
Breastfeeding Use caution Normal dietary use is likely fine; discuss any medicinal or supplemental use with your doctor.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lidocaine and Peanut Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Peanut Oil and Lidocaine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • A severe allergic reaction / An allergic reaction Worth acting on Additional detail

    Peanut Oil

    “Peanut oil can cause a severe allergic reaction in individuals allergic to the Fabaceae family. Members of this family include peanuts and soybeans. Peanut allergy is the number one cause of fatal food-induced anaphylaxis with hypersensitivity in 6% to 8% of children and 1% of adults. Various peanut protein allergens have been identified.”

    Peanut Oil · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 94311. Akhtar S, Khalid N, Ahmed I, Shahzad A, Suleria HA. Physicochemical characteristics, functional properties, and nutritional benefits of peanut oil: a review. Crit Rev Food Sci Nutr. 2014;54(12):1562-75. PubMed

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

Effects for Lidocaine come from the ADVERSE REACTIONS section of its FDA label; effects for Peanut Oil come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 96,036 voluntary FDA FAERS reports for Lidocaine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Lidocaine

This page covers Peanut Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lidocaine page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Fever Bark (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 111 moderate · 31 minor.

From our pharmacist’s overview on the Lidocaine page

“Lidocaine (Xylocaine) deserves genuine care on this page, and I would learn its three major-rated entries first. Grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Lidocaine interaction page

How much people look this up

Where Peanut Oil and Lidocaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Peanut Oil
Steady interest

#1,187 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lidocaine
Top 10%

#232 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Peanut Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Peanut Oil and Lidocaine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Peanut Oil

What is Peanut Oil?

  • Cooking and frying
  • Skin moisturizing and massage
  • Carrier oil for other ingredients
  • Earwax softening (folk use)
  • Dry or chapped skin

Peanut oil is a food-grade oil pressed from peanuts, used mainly for cooking and as a skin or massage oil. It is generally considered safe as a food, but people with peanut allergy should be cautious, especially with crude (less-refined) oils, and there is little strong evidence for medicinal benefits.

Arachis hypogaea · Fabaceae · Oil pressed from the seeds (peanuts) · Cooking oil, topical/massage oil, ingredient in skin and hair products, carrier oil, some injectable medication formulations

An interaction check asks whether these two react with each other — it does not ask whether Peanut Oil is a good idea for someone in your situation. Here is what our Peanut Oil record says about it on its own.

Peanut Oil: dosing

There is no established medicinal dose for peanut oil. As a cooking oil, it is used in normal culinary amounts, like any other vegetable oil.If you are using a product that contains peanut oil for skin care or another purpose, follow the directions on the label.

From our Peanut Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Peanut Oil monograph & all interactions
Medication

About Lidocaine Transdermal Patch

What Is Lidocaine Transdermal Patch Used For?

Brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, Lidoject-2, Duo-Trach Kit, Octocaine, Lidoderm, Ztlido

Lidocaine skin patches are applied directly to the painful area to treat post-herpetic neuralgia (PHN) — the persistent burning or aching nerve pain that can remain after a shingles outbreak.

Lidoderm (lidocaine patch 5%) and ZTlido (lidocaine topical system 1.8%) are both indicated for this use in adults. Note that despite their different strengths, one ZTlido topical system provides equivalent lidocaine exposure to one Lidoderm patch.

Most-Reported Side Effects for Lidocaine

From FAERS, the FDA’s public side-effect reporting system (96,036 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 4,961 reports
Fatigue 4,867 reports
Headache 4,439 reports
Product quality issue 3,920 reports
Dyspnea 3,658 reports
See full Lidocaine Transdermal Patch drug information
Keep checking

Other Drugs & Peanut Oil

Browse every other medication we’ve checked against Peanut Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Peanut Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Peanut Oil list.

See the full Peanut Oil interactions page
See every supplement checked against Lidocaine, ranked by severity
Evidence & sources

Peanut Oil References

The 1 references that drive our Peanut Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Akhtar S, Khalid N, Ahmed I, Shahzad A, Suleria HA. Physicochemical characteristics, functional properties, and nutritional benefits of peanut oil: a review. Crit Rev Food Sci Nutr. 2014;54(12):1562-75. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Peanut Oil and Lidocaine Together: Common Questions

Is it safe to take Peanut Oil with Lidocaine?
We do not list a known interaction between Peanut Oil and Lidocaine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Peanut Oil and Lidocaine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Lidocaine interact with any supplements?
Yes. Lidocaine has documented interactions with 145 supplements in our database — Peanut Oil is not one of them. The Lidocaine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Peanut Oil monograph Uses, safety profile, and every drug interaction in one place Lidocaine Transdermal Patch drug information The full plain-English guide to this medication Lidocaine supplement interactions Every supplement checked against Lidocaine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lidocaine and Peanut Oil?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.