Drug & supplement interaction

Peru Balsam + Brexpiprazole

Brexpiprazole brand name: Rexulti.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Peru Balsam and Brexpiprazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Peru Balsam and Brexpiprazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Brexpiprazole and Peru Balsam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Peru Balsam at all — not against Brexpiprazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Peru Balsam safety at a glance

Peru Balsam overall Use caution Generally used topically but is a common cause of allergic and contact skin reactions.
Pregnancy Likely Unsafe When used orally in medicinal amounts; avoid using. There is insufficient reliable information available about the safety of Peru balsam when used topically; av... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used topically because systemic toxicity to babies can occur following application of Peru balsam to the nipples of nursing mothers. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Brexpiprazole and Peru Balsam? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Peru Balsam Itself Has Been Linked To

This is not an interaction — nothing below involves Brexpiprazole. It is the side-effect record for Peru Balsam on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Peru Balsam, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    “Peru balsam can cause kidney damage when taken orally or applied topically in large amounts (18). Topical use is associated with allergic contact dermatitis and other skin reactions (2,18).”

    Peru Balsam · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  • Hives Worth acting on Additional detail

    “There are numerous reports of Peru balsam and its extracts causing allergic contact dermatitis, particularly when present in fragrances, cosmetics, and topical medicines. Among people who undergo patch testing for allergic contact dermatitis, reactions to Peru balsam occur in 4% to 8.4%, of whom 70% are women.”

    Peru Balsam · Natural Medicines adverse-effect record, reported in dermatitis.

    4 sources cited
    1. 100650. Turic P, Lipozencic J, Milavec-Puretic V, Kulisic SM. Contact allergy caused by fragrance mix and Myroxylon pereirae (balsam of Peru) - a retrospective study. Coll Antropol 2011;35(1):83-7.
    2. 100908. Thyssen JP, Carlsen BC, Menné T, Johansen JD. Trends of contact allergy to fragrance mix I and Myroxylon pereirae among Danish eczema patients tested between 1985 and 2007. Contact Dermatitis 2008;59(4):238-44. doi: 10.1111/j.1600-0536.2008.01418.x.
    3. 100909. Avalos-Peralta P, García-Bravo B, Camacho FM. Sensitivity to Myroxylon pereirae resin (balsam of Peru). A study of 50 cases. Contact Dermatitis 2005;52(6):304-6.
    4. 100907. Tan S, Tam MM, Nixon RL. Allergic contact dermatitis to Myroxylon pereirae (Balsam of Peru) in papaw ointment causing cheilitis. Australas J Dermatol 2011;52(3):222-3. doi: 10.1111/j.1440-0960.2011.00772.x. PubMed
  • A skin rash Additional detail

    Recorded for Peru Balsam in the same Natural Medicines adverse-effect record shown under Kidney problems above.

Everything above comes from the Natural Medicines adverse-effect record for Peru Balsam — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Brexpiprazole’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Brexpiprazole column appears here.

Special populations

Peru Balsam in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally in medicinal amounts; avoid using. There is insufficient reliable information available about the safety of Peru balsam when used topically; avoid using.

Lactation Possibly Unsafe

When used topically because systemic toxicity to babies can occur following application of Peru balsam to the nipples of nursing mothers.

Lactation Likely Unsafe

When used orally in medicinal amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Brexpiprazole

This page covers Peru Balsam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Brexpiprazole page lists 177 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Indian Snakeroot (major), Lithium (major) and Rauvolfia Vomitoria (major).

By severity: 6 major · 130 moderate · 41 minor.

From our pharmacist’s overview on the Brexpiprazole page

“Brexpiprazole (Rexulti) treats schizophrenia and is added to antidepressants for depression, and its supplement list warrants real care before you add anything to it. The bulk of the 177 entries change how your liver clears the drug, so grapefruit can push levels up while St.”

Reviewed by 2 · Jul 18, 2026

Open the Brexpiprazole interaction page

How much people look this up

Where Peru Balsam and Brexpiprazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Peru Balsam
Steady interest

#1,428 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Brexpiprazole
Top half

#983 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Peru Balsam reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Peru Balsam and Brexpiprazole records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Peru Balsam

What is Peru Balsam?

  • Wound and skin healing
  • Hemorrhoids
  • Coughs and sore throat
  • Antimicrobial and antiseptic
  • Diaper rash and minor skin irritation

Peru Balsam is a fragrant tree resin used mainly in topical products for wounds, hemorrhoids, and skin care, and sometimes in cough and throat remedies. Evidence for most uses is limited and largely traditional, and it is a well-known cause of allergic skin reactions, so use it cautiously and check with your pharmacist or doctor first.

Myroxylon balsamum var. pereirae · Fabaceae · Balsam (resin) obtained from the tree bark · Topical ointments, creams, suppositories, lozenges, and as a fragrance ingredient

An interaction check asks whether these two react with each other — it does not ask whether Peru Balsam is a good idea for someone in your situation. Here is what our Peru Balsam record says about it on its own.

Peru Balsam: dosing

There is no well-established standardized dose for Peru Balsam. It is usually found as one ingredient in finished topical products, lozenges, or syrups rather than as a stand-alone supplement.Follow the directions on the specific product label, and use the smallest amount needed.

From our Peru Balsam monograph — the full record covers uses, side effects and every documented interaction.

Read the full Peru Balsam monograph & all interactions
Medication

About Brexpiprazole

What Is Brexpiprazole Used For?

Brand name: Rexulti

Brexpiprazole tablets are approved for two uses in adults: as an add-on (adjunctive) treatment alongside antidepressants for major depressive disorder (MDD), and as a treatment for schizophrenia. These uses apply to both the generic brexpiprazole tablets and Rexulti.

Rexulti has one additional approved use: treating agitation associated with dementia due to Alzheimer's disease in adults. Rexulti is also approved for schizophrenia in adolescents ages 13 and older. Note that Rexulti is not approved for dementia-related psychosis without agitation from Alzheimer's disease, and it is not meant to be used on an as-needed basis for Alzheimer's-related agitation.

Most-Reported Side Effects for Brexpiprazole

From FAERS, the FDA’s public side-effect reporting system (16,505 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Weight increased 1,702 reports
Akathisia 869 reports
Tremor 654 reports
Anxiety 612 reports
Tardive dyskinesia 599 reports
See full Brexpiprazole drug information
Keep checking

Other Drugs & Peru Balsam

Browse every other medication we’ve checked against Peru Balsam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Peru Balsam against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Peru Balsam list.

See the full Peru Balsam interactions page
See every supplement checked against Brexpiprazole, ranked by severity
Evidence & sources

Peru Balsam References

The 7 references that drive our Peru Balsam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Turic P, Lipozencic J, Milavec-Puretic V, Kulisic SM. Contact allergy caused by fragrance mix and Myroxylon pereirae (balsam of Peru) - a retrospective study. Coll Antropol 2011;35(1):83-7.
  5. Tan S, Tam MM, Nixon RL. Allergic contact dermatitis to Myroxylon pereirae (Balsam of Peru) in papaw ointment causing cheilitis. Australas J Dermatol 2011;52(3):222-3. doi: 10.1111/j.1440-0960.2011.00772.x. PubMed
  6. Thyssen JP, Carlsen BC, Menné T, Johansen JD. Trends of contact allergy to fragrance mix I and Myroxylon pereirae among Danish eczema patients tested between 1985 and 2007. Contact Dermatitis 2008;59(4):238-44. doi: 10.1111/j.1600-0536.2008.01418.x.
  7. Avalos-Peralta P, García-Bravo B, Camacho FM. Sensitivity to Myroxylon pereirae resin (balsam of Peru). A study of 50 cases. Contact Dermatitis 2005;52(6):304-6.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Peru Balsam and Brexpiprazole Together: Common Questions

Is it safe to take Peru Balsam with Brexpiprazole?
We do not list a known interaction between Peru Balsam and Brexpiprazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Brexpiprazole interact with any supplements?
Yes. Brexpiprazole has documented interactions with 177 supplements in our database — Peru Balsam is not one of them. The Brexpiprazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Peru Balsam monograph Uses, safety profile, and every drug interaction in one place Brexpiprazole drug information The full plain-English guide to this medication Brexpiprazole supplement interactions Every supplement checked against Brexpiprazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Brexpiprazole and Peru Balsam?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.