Drug & supplement interaction

Picamilon + Metipranolol

Metipranolol brand name: OptiPranolol.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Picamilon and Metipranolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Picamilon and Metipranolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metipranolol and Picamilon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Picamilon safety at a glance

Picamilon overall Use caution Human safety data are limited and its legal status as a supplement is questionable in some countries.

Pregnancy Avoid No reliable safety data exist, so it should be avoided during pregnancy.

Breastfeeding Avoid No safety information is available, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metipranolol and Picamilon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Keep it in perspective

Picamilon Does Interact With Other Medications

Picamilon has 3 moderate known drug interactions in our database — Metipranolol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 3 No known interaction 2,827 (incl. Metipranolol)

Taking anything else?

Check Another of Your Medications Against Picamilon

Covers the 2,830 medications we’ve checked against Picamilon. Pick one to open its full report.

Overlapping uses

What Metipranolol Is Prescribed For, and What Picamilon Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Metipranolol is a prescription medicine with approved uses on its FDA label. Picamilon is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Picamilon has been studied for:

Glaucoma studied, not established Picamilon has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Picamilon for glaucoma
Preliminary clinical research shows that picamilon seems to improve central and peripheral visual fields in patients with open-angle glaucoma, with some patients reporting improvements in light sensitivity and acuity of vision. The dose and duration of picamilon used in this study is not available. Also, the apparent lack of a control group limits the validity of these findings.
1 source cited

100618. Kolomoitseva EM, Ermakova VN, Abdulkadyrova MZh. Results of pikamilon use in the treatment of patients with open-angle glaucoma [abstract only]. Vestn Oftalmol 1994;110(4):4-7.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Metipranolol on your own; if you are taking Picamilon for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Picamilon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 135 real supplement products containing Picamilon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Picamilon. Even though Picamilon itself has no known interaction with Metipranolol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Picamilon and Metipranolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Picamilon

Top half

#380 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Metipranolol

Steady interest

#1,553 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Picamilon reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Picamilon and Metipranolol records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Picamilon

What is Picamilon?

Anxiety and stress
Mental focus and cognition
Low mood
Migraine or headache
Fatigue and energy

Picamilon is a synthetic compound made by joining niacin (vitamin B3) and GABA, originally developed in the former Soviet Union as a prescription drug. It is sold in some countries as a supplement for anxiety, focus, and mood, but high-quality human evidence is very limited, and U.S. regulators have stated it does not qualify as a legal dietary supplement ingredient. Talk to a pharmacist or doctor before using it.

Synthetic compound (not from a plant) · Capsules, tablets, powder

An interaction check asks whether these two react with each other — it does not ask whether Picamilon is a good idea for someone in your situation. Here is what our Picamilon record says about it on its own.

Picamilon: dosing

There is no officially established or standardized dose of picamilon for supplement use, and quality control of products is uncertain.If a product is available to you, follow the directions on the label and do not exceed them.

From our Picamilon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Picamilon monograph & all interactions

Medication

About Metipranolol Ophthalmic

What Is Metipranolol Ophthalmic Used For?

Brand name: OptiPranolol

Ophthalmic metipranolol is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. Metipranolol is in a class of medications called beta-blockers. It works by decreasing the pressure in the eye.

See full Metipranolol Ophthalmic drug information

Keep checking

Other Drugs & Picamilon

Browse every other medication we’ve checked against Picamilon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

3Moderate

0Minor

2,826No known interaction

3 Moderate 2,826 No interaction

Moderate

3 interactions

No interaction 2,826 drugs checked — show the list

We also checked Picamilon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Picamilon list.

See the full Picamilon interactions page

See every supplement checked against Metipranolol, ranked by severity

Evidence & sources

Picamilon References

The 3 references that drive our Picamilon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Avula B, Chittiboyina AG, Sagi S, et al. Identification and quantification of vinpocetine and picamilon in dietary supplements sold in the United States. Drug Test Anal. 2016;8(3-4):334-43. PubMed
Vishnevskii EL, Guseva NB. Validation of the treatment of the neurogenic bladder in children with myelodysplasia using pikamilon [abstract only]. Urol Nefrol (Mosk) 1998;(2):27-30.
Kolomoitseva EM, Ermakova VN, Abdulkadyrova MZh. Results of pikamilon use in the treatment of patients with open-angle glaucoma [abstract only]. Vestn Oftalmol 1994;110(4):4-7.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Picamilon and Metipranolol Together: Common Questions

Is it safe to take Picamilon with Metipranolol?

We do not list a known interaction between Picamilon and Metipranolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Picamilon and Metipranolol used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Picamilon in each. That is a conversation for your prescriber, especially if Metipranolol is being adjusted to a target.

Does Picamilon interact with any other medications?

Yes. Picamilon has 3 documented drug interactions in our database — Metipranolol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Picamilon monograph Uses, safety profile, and every drug interaction in one place Metipranolol Ophthalmic drug information The full plain-English guide to this medication Metipranolol supplement interactions Every supplement checked against Metipranolol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metipranolol and Picamilon?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.