Drug & supplement interaction

Poinsettia + Dextromethorphan

Dextromethorphan brand names: Hold, Benylin Adult, Benylin Pediatric, Theraflu Thin Strips Long Acting Cough, Neo Citran Thin Strips Cough.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Poinsettia and Dextromethorphan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Poinsettia and Dextromethorphan

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dextromethorphan and Poinsettia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Poinsettia at all — not against Dextromethorphan, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Poinsettia safety at a glance

Poinsettia overall Use caution Not intended for internal use; the sap can irritate skin, eyes, and the digestive tract.
Pregnancy Possibly Unsafe When used orally or topically; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or topically; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dextromethorphan and Poinsettia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Poinsettia Itself Has Been Linked To

This is not an interaction — nothing below involves Dextromethorphan. It is the side-effect record for Poinsettia on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Poinsettia, this list is the first place to look.

  • Diarrhea / Vomiting / Nausea Additional detail

    “Orally, poinsettia can cause gastrointestinal irritation, including nausea, vomiting, and diarrhea.”

    Poinsettia · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 96374. Petersen DD. Common plant toxicology: a comparison of national and southwest Ohio data trends on plant poisonings in the 21st century. Toxicol Appl Pharmacol. 2011;254(2):148-53. PubMed
    2. 100568. Evens ZN, Stellpflug SJ. Holiday plants with toxic misconceptions. West J Emerg Med. 2012;13(6):538-542. PubMed
  • A skin rash Additional detail

    “Topically, poinsettia can cause local irritation, contact dermatitis, mucosal burns, and keratoconjunctivitis in some people (17, 3838,100568).”

    Poinsettia · Natural Medicines adverse-effect record, reported in burns.

Everything above comes from the Natural Medicines adverse-effect record for Poinsettia — expand a row for the licensed statement it rests on. We haven’t matched Dextromethorphan to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Dextromethorphan.

Special populations

Poinsettia in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or topically; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Poinsettia or Dextromethorphan

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Poinsettia or Dextromethorphan, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Dextromethorphan

This page covers Poinsettia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan page lists 171 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 125 moderate · 42 minor.

From our pharmacist’s overview on the Dextromethorphan page

“A glass of grapefruit juice can push dextromethorphan (Benylin, Hold, and other cough medicines) to higher levels than intended, one of four major-rated entries among the 171 supplements and herbs on file, and the list as a whole warrants real care. Most interactions trace back to the liver enzymes (CYP3A4 and CYP2D6) that clear dextro…”

Reviewed by 2 · Jul 18, 2026

Open the Dextromethorphan interaction page

How much people look this up

Where Poinsettia and Dextromethorphan Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Poinsettia
Steady interest

#1,324 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dextromethorphan
Top 25%

#324 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Poinsettia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Poinsettia and Dextromethorphan records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Poinsettia

What is Poinsettia?

  • Traditional folk skin remedies
  • Traditional use as a topical poultice
  • Folk use for fever
  • Decorative ornamental plant (most common use today)

Poinsettia is best known as a popular holiday ornamental plant, not a proven dietary supplement, and there is no reliable evidence that it works for any health condition. While its toxicity is often exaggerated, the plant and its milky sap can cause stomach upset and skin or eye irritation, so it is not recommended for medicinal use. If you are considering any herbal product, talk with your pharmacist or doctor first.

Euphorbia pulcherrima · Euphorbiaceae · Leaves, stems, and milky sap (latex); not a true medicinal supplement · Rarely used as a supplement; historically the plant parts and sap have been used in traditional folk preparations

An interaction check asks whether these two react with each other — it does not ask whether Poinsettia is a good idea for someone in your situation. Here is what our Poinsettia record says about it on its own.

Poinsettia: dosing

There is no established or recommended dose for poinsettia because it is not a recognized dietary supplement and is not intended for internal use. No standardized products exist, and safe amounts are unknown.Given the lack of evidence and the risk of irritation, poinsettia should not be taken as a remedy.

From our Poinsettia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Poinsettia monograph & all interactions
Medication

About Dextromethorphan

What Is Dextromethorphan Used For?

Brand names: Hold, Benylin Adult, Benylin Pediatric, Theraflu Thin Strips Long Acting Cough, Neo Citran Thin Strips Cough

Dextromethorphan temporarily relieves cough due to minor throat and bronchial irritation, such as the kind that comes with the common cold or breathing in irritants. It also helps reduce the urge to cough so you — or your child — can get to sleep.

Some products, including CVS Long Acting Cough and Premier Value Tussin Cough oral liquids, are also indicated to help loosen phlegm (mucus) and thin bronchial secretions to help drain the airways.

See full Dextromethorphan drug information
Keep checking

Other Drugs & Poinsettia

Browse every other medication we’ve checked against Poinsettia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Poinsettia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Poinsettia list.

See the full Poinsettia interactions page
See every supplement checked against Dextromethorphan, ranked by severity
Evidence & sources

Poinsettia References

The 4 references that drive our Poinsettia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Krenzelok EP, Jacobsen TD, Aronis JM. Poinsettia exposures have good outcomes...just as we thought. Am J Emerg Med 1996;14:671-4. PubMed
  3. Petersen DD. Common plant toxicology: a comparison of national and southwest Ohio data trends on plant poisonings in the 21st century. Toxicol Appl Pharmacol. 2011;254(2):148-53. PubMed
  4. Evens ZN, Stellpflug SJ. Holiday plants with toxic misconceptions. West J Emerg Med. 2012;13(6):538-542. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Poinsettia and Dextromethorphan Together: Common Questions

Is it safe to take Poinsettia with Dextromethorphan?
We do not list a known interaction between Poinsettia and Dextromethorphan. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Dextromethorphan interact with any supplements?
Yes. Dextromethorphan has documented interactions with 171 supplements in our database — Poinsettia is not one of them. The Dextromethorphan interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Poinsettia monograph Uses, safety profile, and every drug interaction in one place Dextromethorphan drug information The full plain-English guide to this medication Dextromethorphan supplement interactions Every supplement checked against Dextromethorphan, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dextromethorphan and Poinsettia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.