Proline + Epirubicin
Epirubicin brand name: Ellence.
We found no known interaction between Proline and Epirubicin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Proline and Epirubicin
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Epirubicin and Proline in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Proline at all — not against Epirubicin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Proline safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Epirubicin
This page covers Proline only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Epirubicin page lists 24 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Acerola (moderate), Alpha-lipoic Acid (moderate), Coffee Charcoal (moderate) and European Mandrake (moderate).
By severity: 1 major · 14 moderate · 9 minor.
From our pharmacist’s overview on the Epirubicin page
“Epirubicin (Ellence) is chemotherapy, most often used for breast cancer, and when a supplement can weaken the treatment itself, the 24 ingredients on this list deserve real caution. The lone major entry is activated charcoal, which can pull the drug back out of the body even though epirubicin is given by IV, since the medicine recircul…”
Reviewed by 2 · Jul 18, 2026
Taking Proline as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,054 real supplement products containing Proline, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Proline. Even though Proline itself has no known interaction with Epirubicin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Proline and Epirubicin Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#208 of 1,452 supplements looked up here in the last 7 days
#1,431 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Proline reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Proline and Epirubicin records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Proline
What is Proline?
- Joint and connective tissue support
- Skin health and wound healing
- Collagen production
- Athletic recovery
- General amino acid supplementation
Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that taking proline supplements improves skin, joints, or healing is limited. For most healthy people a balanced diet supplies plenty, so talk to your pharmacist or doctor before adding a supplement.
Amino acid (made by the body and found in protein-rich foods) · Capsules, powders, and as part of collagen or amino acid blends
An interaction check asks whether these two react with each other — it does not ask whether Proline is a good idea for someone in your situation. Here is what our Proline record says about it on its own.
Proline: dosing
There is no well-established standard dose of proline as a supplement. Amounts vary widely between products, and proline is often combined with other amino acids or collagen rather than taken alone.If you choose to use a proline-containing product, follow the directions on the label and do not exceed the recommended amount.
From our Proline monograph — the full record covers uses, side effects and every documented interaction.
About Epirubicin
What Is Epirubicin Used For?
Brand name: Ellence
Ellence (epirubicin), given as an intravenous injection, is used as part of adjuvant (post-surgery) combination chemotherapy in patients with breast cancer who have evidence of tumor involvement in the axillary lymph nodes (lymph nodes under the arm) following surgical removal of the primary tumor.
It is not used alone — Ellence is always given as part of a multi-drug regimen alongside other chemotherapy agents.
Other Drugs & Proline
Browse every other medication we’ve checked against Proline — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Proline against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Atorvastatin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Pregabalin ›
- Gabapentin ›
- Amphetamine ›
- Acetaminophen, Codeine ›
- Isotretinoin ›
- Azithromycin ›
- Dextroamphetamine ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Proline list.
Proline References
The 4 references that drive our Proline monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
- Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
- Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
- Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Proline and Epirubicin Together: Common Questions
Is it safe to take Proline with Epirubicin?
Does Epirubicin interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Epirubicin and Proline?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.