Drug & supplement interaction

Proline + Ibuprofen

Ibuprofen brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Proline and Ibuprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Proline and Ibuprofen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ibuprofen and Proline in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Proline at all — not against Ibuprofen, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Proline safety at a glance

Proline overall Use caution Generally considered low-risk from food, but supplement safety has not been well studied.
Pregnancy Use caution Not enough reliable data on supplemental doses, so it is best to avoid extra amounts unless your doctor advises.
Breastfeeding Use caution Safety of supplemental doses while breastfeeding is not established, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ibuprofen and Proline? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ibuprofen’s Own FDA Label Lists

This is not an interaction — none of it involves Proline. These are the most notable effects listed in the ADVERSE REACTIONS section of Ibuprofen’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • Heart failure Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Raised blood pressure Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • Bloating or gas
  • Fever

Showing the 10 most notable of 15 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ibuprofen. Read the label on DailyMed › Where a percentage is shown, it is the share of 283,500 voluntary FDA FAERS reports for Ibuprofen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Proline’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Proline side to compare — that is a limit of the record, not a statement that Proline has no side effects.

From our Q&A

Questions About Proline or Ibuprofen

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Proline or Ibuprofen, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ibuprofen

This page covers Proline only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen page lists 286 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 243 moderate · 36 minor.

From our pharmacist’s overview on the Ibuprofen page

“Most people treat ibuprofen (Advil, Motrin) as an everyday pain reliever, which is exactly why this list of 286 interacting supplements deserves real attention rather than a shrug. The dominant pattern by far is bleeding: 202 of these ingredients can add to the bleeding and stomach irritation ibuprofen already causes, and the seven maj…”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen interaction page

One more smart check

Taking Proline as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,054 real supplement products containing Proline, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Proline. Even though Proline itself has no known interaction with Ibuprofen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Proline and Ibuprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Proline
Top 25%

#207 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen
Top 1%

#19 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Proline reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Proline and Ibuprofen records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Proline

What is Proline?

  • Joint and connective tissue support
  • Skin health and wound healing
  • Collagen production
  • Athletic recovery
  • General amino acid supplementation

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that taking proline supplements improves skin, joints, or healing is limited. For most healthy people a balanced diet supplies plenty, so talk to your pharmacist or doctor before adding a supplement.

Amino acid (made by the body and found in protein-rich foods) · Capsules, powders, and as part of collagen or amino acid blends

An interaction check asks whether these two react with each other — it does not ask whether Proline is a good idea for someone in your situation. Here is what our Proline record says about it on its own.

Proline: dosing

There is no well-established standard dose of proline as a supplement. Amounts vary widely between products, and proline is often combined with other amino acids or collagen rather than taken alone.If you choose to use a proline-containing product, follow the directions on the label and do not exceed the recommended amount.

From our Proline monograph — the full record covers uses, side effects and every documented interaction.

Read the full Proline monograph & all interactions
Medication

About Ibuprofen

What Is Ibuprofen Used For?

Brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, Ibugel Forte, Arthrofen, Ebufac, Rimafen, Calprofen, Fenpaed, Galprofen, Nurofen for Children, Orbifen for Children, Brufen, Brufen Retard, Fenbid, Tab-Profen, Ibuprofen, Calodor

Oral ibuprofen products (tablets, coated tablets, and liquid-filled capsules) are used to temporarily relieve minor aches and pains from headache, backache, toothache, muscular aches, menstrual cramps, minor arthritis pain, and the common cold, and to temporarily reduce fever. The oral prescription tablet (Ibu) is also indicated for the signs and symptoms of rheumatoid arthritis and osteoarthritis, mild to moderate pain, and primary dysmenorrhea (painful periods).

Caldolor, an intravenous (IV) form, is approved for adults and children 3 months and older to manage mild to moderate pain, to manage moderate to severe pain alongside opioid pain medicines, and to reduce fever. A separate intravenous solution, Ibuprofen Lysine, is used specifically in premature infants to close a patent ductus arteriosus (PDA) — an abnormal blood vessel connection near the heart — when standard medical management has not worked.

Most-Reported Side Effects for Ibuprofen

From FAERS, the FDA’s public side-effect reporting system (283,500 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 18,755 reports
Nausea 18,290 reports
Headache 16,566 reports
Arthralgia 13,469 reports
Dyspnea 13,139 reports
See full Ibuprofen drug information
Keep checking

Other Drugs & Proline

Browse every other medication we’ve checked against Proline — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Proline against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Proline list.

See the full Proline interactions page
See every supplement checked against Ibuprofen, ranked by severity
Evidence & sources

Proline References

The 4 references that drive our Proline monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
  2. Gracia-Marco L, Bel-Serrat S, Cuenca-Garcia M, et al. Amino acids intake and physical fitness among adolescents. Amino Acids. 2017;49(6):1041-1052. PubMed
  3. Jamdar J, Rao B, Netke S, et al. Reduction in tibial shaft fracture healing time with essential nutrient supplementation containing ascorbic acid, lysine, and proline. J Altern Complement Med. 2004;10(6):915-6.
  4. Mehl AA, Damião AO, Viana SD, Andretta CP. Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair. J Wound Care 2021;30(1):26-31. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Proline and Ibuprofen Together: Common Questions

Is it safe to take Proline with Ibuprofen?
We do not list a known interaction between Proline and Ibuprofen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Ibuprofen interact with any supplements?
Yes. Ibuprofen has documented interactions with 286 supplements in our database — Proline is not one of them. The Ibuprofen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Proline monograph Uses, safety profile, and every drug interaction in one place Ibuprofen drug information The full plain-English guide to this medication Ibuprofen supplement interactions Every supplement checked against Ibuprofen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ibuprofen and Proline?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.