Roman Chamomile + Zolpidem
Zolpidem brand names: Ambien CR, Intermezzo, Sublinox.
We found no known interaction between Roman Chamomile and Zolpidem in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Zolpidem states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Roman Chamomile and Zolpidem
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Zolpidem and Roman Chamomile in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Roman Chamomile at all — not against Zolpidem, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Roman Chamomile safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Roman Chamomile in Pregnancy & Breastfeeding
When used orally in medicinal amounts. Roman chamomile is believed to be an abortifacient. Some population research has found a possible link between the use of Roman chamomile and an increased incidence of reduced birth weight, threatened miscarriage, and preterm labor. There is insufficient reliable information available about the safety of the topical use of Roman chamomile during pregnancy; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Zolpidem Products Have a Food Rule — Roman Chamomile Should Not Break It
At least one FDA label for a product containing Zolpidem says to take it with food. If you take Roman Chamomile on an empty stomach out of habit, keep them separate — and take Zolpidem with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Zolpidem products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Administration The effect of Zolpidem Tartrate Tablets may be slowed by ingestion with or immediately after a meal.
From the Dosage and Administration section of the FDA label we read for Zolpidem — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Zolpidem Is Prescribed For, and What Roman Chamomile Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Zolpidem is a prescription medicine with approved uses on its FDA label. Roman Chamomile is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Zolpidem is prescribed for: Zolpidem is used short-term for insomnia. Most formulations — including Ambien, oral tablets, and Zolpidem Tartrate Capsules — are approved to help people who have trouble falling asleep at bedtime. Zolpidem Tartrate Capsules are specifically indicated for adults under 65. The extended-release formulations (including Zolpidem Tartrate Extended-Release Tablets) help with both falling asleep and staying asleep through the night.
Read the rest of what Zolpidem is prescribed for
Sublingual tablets (Edluar, Zolpidem Tartrate Sublingual Tablet, and Zolpidem tartrate sublingual) are taken as needed when you wake up in the middle of the night and cannot get back to sleep — but only if at least 4 hours of sleep time remain before you need to be up.
Roman Chamomile has been studied for:
-
Insomnia studied, not established Roman Chamomile has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Roman Chamomile for insomnia
Although there is interest in using oral or inhaled Roman chamomile for insomnia, there is insufficient reliable information about the clinical effects of Roman chamomile for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Zolpidem on your own; if you are taking Roman Chamomile for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Roman Chamomile or Zolpidem
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Roman Chamomile or Zolpidem, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Take NyQuil Long-Term To Help Treat Insomnia? ›
- Does Ambien Cause Withdrawal Symptoms After Stopping? ›
- Taking NyQuil With Ambien - Interaction Details ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Zolpidem
This page covers Roman Chamomile only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zolpidem page lists 195 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).
By severity: 9 major · 147 moderate · 39 minor.
From our pharmacist’s overview on the Zolpidem page
“Zolpidem (Ambien, Intermezzo) is a sleep medicine that works by slowing the brain, and the 195 supplements and herbal ingredients on this page deserve genuine care, starting with the nine rated major. Most of the list pulls in one of two directions.”
Reviewed by 2 · Jul 18, 2026
Taking Roman Chamomile as Part of a Dietary Supplement Product? Check It for Interactions
We hold 8 real supplement products containing Roman Chamomile, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Roman Chamomile. Even though Roman Chamomile itself has no known interaction with Zolpidem, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Roman Chamomile and Zolpidem Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,323 of 1,452 supplements looked up here in the last 7 days
#418 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Roman Chamomile reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Roman Chamomile and Zolpidem records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Roman Chamomile
What is Roman Chamomile?
- Digestive upset
- Anxiety and relaxation
- Sleep support
- Skin irritation
- Menstrual cramps
Roman chamomile is a daisy-family herb used traditionally as a calming tea and as an oil for digestion, mild anxiety, and skin comfort. Solid human evidence is limited for most uses, but it is generally considered safe in food and tea amounts for most adults. People allergic to ragweed and related plants should be cautious, and pregnant or breastfeeding people should check with a doctor first.
Chamaemelum nobile · Asteraceae · Flowers (and essential oil) · Tea, capsules, liquid extract, essential oil, topical creams
An interaction check asks whether these two react with each other — it does not ask whether Roman Chamomile is a good idea for someone in your situation. Here is what our Roman Chamomile record says about it on its own.
Roman Chamomile: dosing
There is no official standardized dose for Roman chamomile. The amount varies widely depending on the product and the form (tea, capsule, or extract).A common traditional use is one cup of chamomile tea made from the dried flowers, taken up to a few times a day. For capsules or liquid extracts, follow the directions on the product label, since strengths differ between brands.
From our Roman Chamomile monograph — the full record covers uses, side effects and every documented interaction.
About Zolpidem
What Is Zolpidem Used For?
Brand names: Ambien CR, Intermezzo, Sublinox
Zolpidem is used short-term for insomnia. Most formulations — including Ambien, oral tablets, and Zolpidem Tartrate Capsules — are approved to help people who have trouble falling asleep at bedtime. Zolpidem Tartrate Capsules are specifically indicated for adults under 65.
The extended-release formulations (including Zolpidem Tartrate Extended-Release Tablets) help with both falling asleep and staying asleep through the night. Sublingual tablets (Edluar, Zolpidem Tartrate Sublingual Tablet, and Zolpidem tartrate sublingual) are taken as needed when you wake up in the middle of the night and cannot get back to sleep — but only if at least 4 hours of sleep time remain before you need to be up.
Other Drugs & Roman Chamomile
Browse every other medication we’ve checked against Roman Chamomile — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Roman Chamomile against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Roman Chamomile list.
Roman Chamomile References
The 6 references that drive our Roman Chamomile monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. PubMed
- Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Roman Chamomile and Zolpidem Together: Common Questions
Is it safe to take Roman Chamomile with Zolpidem?
Do Roman Chamomile and Zolpidem have any of the same side effects?
Should I take Roman Chamomile and Zolpidem at the same time of day?
Are Roman Chamomile and Zolpidem used for the same thing?
Does Zolpidem interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.